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| 1 | Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia显示文摘Microglia 玩在由降级的 A 的清理的一个枢轴的角色他们在 lysosomes,在 Alzheimers 疾病(广告) 阻止淀粉的匾致病。最近的证据建议那个 lysosomal 机能障碍导致有毒的蛋白质总数的不够的消除。我们测试了是否与抄写因素 EB (TFEB ) 提高 lysosomal 功能,必要管理者 modulating lysosomal 小径,将在 microglia 支持一个清理。这里,我们证明 TFEB 的那 microglial 表情便于降级和还原剂扔了的纤丝状的 A (fA ) 淀粉的匾,它被 TFEB 的 deacetylation 进一步提高。用集体 spectrometry 分析,我们第一证实了是的 acetylation 一以前 TFEB 的 unreported 修正并且发现那 SIRT1 直接交往了与并且在离氨酸残余 116 点的 deacetylated TFEB。随后,当 TFEB 被击倒时, SIRT1 overexpression 由 TFEB 下游的目标的 upregulating transcriptional 层次提高了 lysosomal 功能和 fA 降级,它能被禁止。而且,在在 microglia 变异的 K116R 的 deacetylated TFEB 的 overexpression 由刺激 lysosomal 生物的续生说加速了细胞内部的 fA 降级并且极大地在 APP/PS1 转基因的老鼠的大脑片减少了扔的淀粉的匾。我们的调查结果表明 TFEB 的 deacetylation 能调整 lysosomal 生物的续生说和 fA 降级,为 attenuating 使 TFEB 的 microglial 激活成为可能的策略在广告的淀粉的匾免职。 | Jintao Bao Liangjun Zheng Qi Zhang Xinya Li Xuefei Zhang Zeyang Li Xue Bai Zhong Zhang Wei Huo Xuyang Zhao Shujiang Shang Qingsong Wang Chen Zhang Jianguo Ji | 2016 | Protein & Cell2016，7，6： | 10 |
| 2 | Augmentation plating in hypertrophic non-union after nail fixation of femoral shaft fracture compared with exchange plating Augmentation plating in hypertrophic non-union after nail fixation of femoral shaft fracture compared with exchange plating Augmentation plating in hypertrophic non-union after nail fixation of femoral shaft fracture compared with exchange plating显示文摘 | Jiang Liangjun Pan Zhijun Zheng Qiang | 2014 | Chinese Medical Journal2014，，16： | 9 |
| 3 | Chemical con-stituents from Monochasma savatieri显示文摘 | Zheng Wei Tan Xingqi Guo Liangjun | 2012 | Chin J Nat Med2012，10，2： | 1 |
| 4 | Opportunistic Relaying Schemes for Amplify and Forward Bidirectional Relay Channels with Multi antenna Sources显示文摘We consider a two-way relay network where the Amplify-and-Forward (AF) protocol is adopted by all relays in this paper.The network consists of two multi-antenna source nodes and multiple distributed single-antenna relays.Two opportunistic relaying schemes are proposed to efficiently utilize the antennas of the source nodes and the relay nodes.In the first scheme,the best relay is selected out by a max-min-max criterion before transmitting.After that,at each source,only the antenna with the largest channel gain between itself and the best relay is activated to transmit and receive signals with full power.In the second scheme,assisted by the best relay which is selected by the typical max-min criterion,both source nodes use all their antennas to exchange data,and match filter beamforming techniques are employed at both source nodes.Further analyses show that all schemes can achieve the full diversity order,and the conclusions are not only mathematically demonstrated but numerically illustrated.System performance comparisons are carried out by numerical methods in terms of rate sum and outage probability,respectively.The beamforming assisted scheme can be found to be superior to the antenna selection scheme when accurate Channel State Information (CSI) is available at the transmitters.Otherwise,the latter is very suitable. | Wang Zibin Yuan Fu Ding Hong Xiang Liangjun Zheng Linhua | 2012 | China Communications2012，9，4： | 1 |
| 5 | Formal Verification Platform as a Service:WebAssembly Vulnerability Detection Application显示文摘In order to realize a general-purpose automatic formal verification platform based on WebAssembly technology as a web service(FVPS),which aims to provide an automated report of vulnerability detections,this work builds a Hyperledger Fabric blockchain runtime model.It proposes an optimized methodology of the functional equivalent translation from source program languages to formal languages.This methodology utilizes an external application programming interface(API)table to replace the source codes in compilation,thereby pruning the part of housekeeping codes to ease code inflation.Code inflation is a significant metric in formal language translation.Namely,minor code inflation enhances verification scale and performance efficiency.It determines the efficiency of formal verification,involving launching,running,and memory usage.For instance,path explosion increases exponentially,resulting in out-of-memory.The experimental results conclude that program languages like golang severely impact code inflation.FVPS reduces the wasm code size by over 90%,achieving two orders of optimization magnitude,from 2000 kilobyte(KB)to 90 KB.That means we can cope with golang applications up to 20 times larger than the original in scale.This work eliminates the gap between Hyperledger Fabric smart contracts and WebAssembly.Our approach is pragmatic,adaptable,extendable,and flexible.Nowadays,FVPS is successfully applied in a Railway-Port-Aviation blockchain transportation system. | LiangJun Deng Hang Lei Zheng Yang WeiZhong Qian XiaoYu Li Hao Wu Sihao Deng RuChao Sha WeiDong Deng | 2023 | Computer Systems Science & Engineering2023，45，5： | 0 |
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