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| 1 | The hierarchy quorum sensing networ in Pseudomonas aeruginosa显示文摘 | Jasmine Lee Lianhui Zhang | 2015 | Protein & Cell2015，6，1： | 76 |
| 2 | Identification of Pns12 as the second silencing suppressor of Rice gall dwarf virus显示文摘RNA silencing is a conserved mechanism found ubiquitously in eukaryotic organisms.It has been used to regulate gene expression and development.In addition,RNA silencing serves as an important mechanism in plants' defense against invasive nucleic acids,such as viruses,transposons,and transgenes.As a counter-defense,most plants,and some animal viruses,encode RNA silencing suppressors to interfere at one or several points of the silencing pathway.In this study,we showed that Pns12 of RGDV (Rice gall dwarf virus) exhibits silencing suppressor activity on the reporter green fluorescent protein in transgenic Nicotiana benthamiana line 16c.Pns12 of RGDV suppressed local silencing induced by sense RNA but had no effect on that induced by dsRNA.Expression of Pns12 also enhanced Potato virus X pathogenicity in N.benthamiana.Collectively,these results suggested that RGDV Pns12 functions as a virus suppressor of RNA silencing,which might target an upstream step of dsRNA formation in the RNA silencing pathway.Furthermore,we showed that Pns12 is localized mainly in the nucleus of N.benthamiana leaf cells. | WU JianGuo WANG ChunZheng DU ZhengGuo CAI LiJun HU MeiQun WU ZuJian LI Yi XIE LianHui | 2011 | Science China(Life Sciences)2011，54，3： | 7 |
| 3 | Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections显示文摘The formation of bacterial biofilms closely associates with infectious diseases.Until now,precise diagnosis and effective treatment of bacterial biofilm infections are still in great need.Herein,a novel multifunctional theranostic nanoplatform based on MnO_(2)nanosheets(MnO_(2)NSs)has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy(aPDT)of bacterial biofilm infections.In this study,MnO_(2)NSs were modified with bovine serum albumin(BSA)and polyethylene glycol(PEG)and then loaded with chlorin e_(6)(Ce_(6))as photosensitizer to form MnO_(2)-BSA/PEG-Ce_(6)nanosheets(MBP-Ce_(6)NSs).After being delivered into the bacterial biofilm-infected tissues,the MBP-Ce_(6)NSs could be decomposed in acidic biofilm microenvironment and release Ce_(6)with Mn^(2+),which subsequently activate both fluorescence(FL)and magnetic resonance(MR)signals for effective dual-mode FL/MR imaging of bacterial biofilm infections.Meanwhile,MnO_(2)could catalyze the decomposing of H2O_(2)in biofilm-infected tissues into O_(2)and relieve the hypoxic condition of biofilm,which significantly enhances the efficacy of aPDT.An in vitro study showed that MBP-Ce_(6)NSs could significantly reduce the number of methicillin-resistant Staphylococcus aureus(MRSA)in biofilms after 635nm laser irradiation.Guided by FL/MR imaging,MRSA biofilm-infected mice can be efficiently treated by MBP-Ce_(6)NSs-based aPDT.Overall,MBP-Ce_(6)NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm,which provides a promising theranostic nanoplatform for bacterial biofilm infections. | Weijun Xiu Siyu Gan Qirui Wen Qiu Qiu Sulai Dai Heng Dong Qiang Li Lihui Yuwen Lixing Weng Zhaogang Teng Yongbin Mou Lianhui Wang | 2020 | Research2020，，1： | 7 |
| 4 | Effects of deformation twins on microstructure evolution,mechanical properties and corrosion behaviors in magnesium alloys-A review显示文摘Due to lattice reorientation,grain segmentation,induced recrystallization,twins play a very important role in regulating texture,refining grains,improving mechanical properties and corrosion resistance,and has received more extensive attention.Numerous studies have shown that{10-12}<10-11>tensile twins(TTWs)are easily activated in large quantities due to the lower critical resolve shear stresses(CRSS).Introduction of TTWs under uniaxial compression improved the strength,ductility,and formability of magnesium(Mg)alloys.Moreover,TTWs produced by multi-directional impact forging(MDIF)can optimize the microstructure by dividing grains and promoting recrystallization,resulting in significant improvement of mechanical properties.Although{10-11}<10-12>compressive twins(CTWs)and{10-11}-{10-12}double twins(DTWs)can promote dynamic recrystallization(DRX),they are also favorable nucleation sites for cracks.In addition,the type and volume fraction of twins can affect the corrosion resistance,and they also play different roles in the corrosion process of different Mg alloys.Twins have shown great potential for improving structure and properties,but a comprehensive and critical discussion of twins in Mg alloys is still lacking.Therefore,based on previous studies,this article reviews the common types and variants of twins in Mg alloys,influencing factors,and their effects on the microstructure,mechanical properties and corrosion resistance.In addition,some interesting ideas are being proposed for further research. | Lianhui Li Wenhong Liu Fugang Qi Di Wu Zhiqiang Zhang | 2022 | Journal of Magnesium and Alloys2022，10，9： | 5 |
| 5 | SERS-based mercury ion detections:principles,strategies and recent advances显示文摘Mercury ion(Hg^(2+)),known as one of the highly toxic and soluble heavy metal ions,is causing serious environmental pollution and irreversible damage to the health.It is urgent to develop some rapid and ultrasensitive methods for detecting trace mercury ions in the environment especially drink water.Surface-enhanced Raman scattering(SERS)is considered as a novel and powerful optical analysis technique since it has the significant advantages of ultra-sensitivity and high specificity.In recent years,the SERS technique and its application in the detection of Hg^(2+)have become more prevalent and compelling.This review provides an overall survey of the development of SERS-based Hg^(2+)detections and presents a summary relating to the basic principles,detection strategies,recent advances and current challenges of SERS for Hg^(2+)detections. | chunyuan song boyue yang yanjun yang lianhui wang | 2016 | Science China Chemistry2016，59，1： | 4 |
| 6 | The TAK1-JNK cascade is required for IRF3 function in the innate immune response显示文摘干扰素规章的因素(IRF ) 3 在病毒或细菌的侵略期间为 chemokines 和 cytokines 的 transcriptional 正式就职是批评的。kinases 坦克有约束力的 kinase (TBK ) 1 并且 Ikappa B kinase (IKK ) 蔚罐头 phosphorylate IRF3 和玩的 C 终端部分在 IRF3 激活的重要角色。在这研究,我们显示出那另外一个 kinase, c-Jun-NH2-terminal kinase (JNK ) ,它的 N 终端丝氨酸上的 phosphorylates IRF3 173 残余,和 TAK1 能经由 JNK 刺激 IRF3 phosphorylation。没有影响 C 终端 phosphorylation, JNK 特定的禁止者 SP600125 禁止 N 终端 phosphorylation。另外, lipopolysaccharide (LPS ) 上的调停 IRF3 的基因表情或 polyinosinic-cytidylic 酸(polyI : C ) 处理被 SP600125 严重地损害,以及为 IRF3 激活的记者基因试金。进一步证实的 TAK1 击倒这些观察。有趣地,组成的活跃 IRF3 (5D ) 能被 SP600125 禁止;JNK1 罐头 synergize IRF3 (5D ) 的行动,然而并非 S173A-IRF3 (5D ) 变异。更重要地, polyI : 没能戏剧性地导致变异的 S173A 和 SP600125 的 phosphorylation 的 C 废除了被 polyI 刺激的 IRF3 phosphorylation 和 dimerization : C。因此,这研究证明 TAK1-JNK 串联为 IRF3 功能被要求,除了 TBK1/IKK 蔚,揭开为激活 mitogen 的蛋白质(地图) 的新机制调整天生的免疫的 kinase。 | Bianhong Zhang Meng Li Liang Chen Kai Yang Yufei Shan Lianhui Zhu Shaogang Sun Lin Li Chen Wang | 2009 | Cell Research2009，19，4： | 4 |
| 7 | Single-Step Organization of Plasmonic Gold Metamaterials with Self-Assembled DNA Nanostructures显示文摘Self-assembled DNA nanostructures hold great promise as nanoscale templates for organizing nanoparticles(NPs)with nearatomistic resolution.However,large-scale organization of NPs with high yield is highly desirable for nanoelectronics and nanophotonic applications.Here,we design fve-strand DNA tiles that can readily self-assemble into well-organized micrometerscale DNA nanostructures.By organizing gold nanoparticles(AuNPs)on these self-assembled DNA nanostructures,we realize the fabrication of one-and two-dimensional Au nanostructures in single steps.We further demonstrate the one-pot synthesis of Au metamaterials for highly amplifed surface-enhanced Raman Scattering(SERS).Tis single-step and high-yield strategy thus holds great potential for fabricating plasmonic metamaterials. | Shaokang Ren Jun Wang Chunyuan Song Qian Li Yanjun Yang Nan Teng Shao Su Dan Zhu Wei Huang Jie Chao Lianhui Wang Chunhai Fan | 2019 | Research2019，，1： | 4 |
| 8 | A Nano-and Micro-Integrated Protein Chip Based on Quantum Dot Probes and a Microfluidic Network显示文摘A novel nano-and micro-integrated protein chip(NMIPC)that can detect proteins with ultrahigh sensitivity has been fabricated.A microfl uidic network(μFN)was used to construct the protein chips,which allowed facile patterning of proteins and subsequent biomolecular recognition.Aqueous phase-synthesized,water-soluble fl uorescent CdTe/CdS core-shell quantum dots(aqQDs),having high quantum yield and high photostability,were used as the signaling probe.Importantly,it was found that aqQDs were compatible with microfluidic format assays,which afforded highly sensitive protein chips for cancer biomarker assays. | Juan Yan Mei Hu Di Li Yao He Rui Zhao Xingyu Jiang Shiping Song Lianhui Wang Chunhai Fan | 2008 | Nano Research2008，1，6： | 3 |
| 9 | Investigation on microstructures and mechanical properties of Mg-6Zn-0.5Ce-xMn(x=0 and 1)wrought magnesium alloys显示文摘The microstructure evolution and mechanical properties of Mg–6Zn–0.5Ce–xMn(x=0 and 1 wt.%)wrought magnesium alloys were researched,and the morphologies and role of Mn element in the experimental alloys were analyzed.The research shows that all of Mn elements form theα-Mn pure phases,which do not participate in the formation of other phases,such as theτ-phases.The mechanical properties of Mn-containing alloys in as-extruded and aged states are superior to Mn-free alloys.During the hot extrusion process,the dispersed fineα-Mn particle phase hinders the migration of grain boundaries and inhibits dynamic recrystallization,which mainly takes effect of grain refining and dispersion hardening.During the aging treatments,the dispersed fineα-Mn particle phase not only hinders the growth of the solution-treated grains,but also becomes the nucleation cores ofβ1 rod-like precipitate phase,which is conducive to increasing the nucleation rate of the precipitate phase.For the aged alloy,the Mn addition mainly takes effect of grain refining and promoting aging strengthening. | Caihong Hou Hongshuai Cao Fugang Qi Qing Wang Lianhui Li Nie Zhao Dingfei Zhang Xiaoping Ouyang | 2022 | Journal of Magnesium and Alloys2022，10，4： | 3 |
| 10 | Complete genome sequence and proteomic analysis of a thermophilic bacteriophage BV1显示文摘Viruses of thermophiles are of great interest due to their roles in gene transfer, global geochemical cycle and evolution of life on earth. However, the thermophilic bacteriophages have not been studied extensively. In this investigation, a typical bacteriophage BV1 was obtained from a thermophilic bacterium Geobacillus sp. 6k512, which was isolated from an inshore hot spring in Xiamen of China. The BV1 contained a double-stranded linear DNA of 35 055 bp, which encodes 54 open reading frames (ORFs). Interestingly, eight of the 54 BV1 ORFs shared sequence similarities to genes from human disease-relevant bacteria. Seven proteins of the purified BV1 virions were identified by proteomic analysis. Determination of BV1 functional genomics would facilitate the better understanding of the mechanism for virus-thermophile interaction. | LIU Bin WU Suijie XIE Lianhui | 2010 | Acta Oceanologica Sinica2010，29，3： | 2 |
| 11 | Polymorphisms of potential drug resistant molecular markers in Plasmodium vivax from China-Myanmar border during 2008-2017显示文摘Background:Plasmodium vivax remains the predominant species at the China–Myanmar border,imposing a major challenge to the recent gains in regional malaria elimination.To closely supervise the emerging of drug resistance in this area,we surveyed the variations in genes potentially correlated with drug resistance in P.vivax parasite and the possible drug selection with time.Methods:A total of 235 P.vivax samples were collected from patients sufering uncomplicated malaria at Yingjiang,Tengchong,and Longling counties,and Nabang port in China,Yunnan province,and Laiza sub-township in Myanmar,from 2008 to 2017.Five potential drug resistance genes were amplifed utilizing nested-PCR and analyzed,including pvdhfr,pvdhps,pvmdr1,pvcrt-o,and pvk12.The Pearson’s Chi-squared test or Fisher’s exact test were applied to determine the statistical frequency diferences of mutations between categorical data.Results:The pvdhfr F57I/L,S58R,T61M and S117T/N presented in 40.6%,56.7%,40.1%,and 56.0% of the sequenced P.vivax isolates,and these mutations signifcantly decreased with years.The haplotype formed by these quadruple mutations predominated in Yingjiang,Tengchong,Longling and Nabang.While a mutation H99S/R(56.6%)dominated in Laiza and increased with time.In pvdhps,the A383G prevailed in 69.2% of the samples,which remained the most prevalent haplotype.However,a signifcant decrease of its occurrence was also noticed over the time.The S382A/C and A553G existed in 8.4% and 30.8% of the isolates,respectively.In pvmdr1,the mutation Y976F occurred at a low frequency in 5/232(2.2%),while T958M was fxed and F1076L was approaching fxed(72.4%).The K10 insertion was detected at an occurrence of 33.2% in pvcrt-o,whereas there was no signifcant diference among the sites or over the time.No mutation was identifed in pvk12.Conclusions:Mutations related with resistance to antifolate drugs are prevalent in this area,while their frequencies decrease signifcantly with time,suggestive of increased susceptibility of P.vivax parasite to antifolate drugs.Resistance to chloroquine(CQ)is possibly emerging.However,since the molecular mechanisms underneath CQ resistance is yet to be better understood,close supervision of clinical drug efciency and continuous function investigation is urgently needed to alarm drug resistance. | Zhensheng Wang Chunyan Wei Yunchun Pan Zhihua Wang Xin Ji Qianqian Chen Lianhui Zhang Zenglei Wang Heng Wang | 2022 | Infectious Diseases of Poverty2022，11，2： | 2 |
| 12 | Biological receptor-inspired flexible artificial synapse based on ionic dynamics显示文摘The memristor has been regarded as a promising candidate for constructing a neuromorphic computing platform that is capable of confronting the bottleneck of the traditional von Neumann architecture.Here,inspired by the working mechanism of the G-protein-linked receptor of biological cells,a novel double-layer memristive device with reduced graphene oxide(rGO)nanosheets covered by chitosan(an ionic conductive polymer)as the channel material is constructed.The protons in chitosan and the functional groups in rGO nanosheets imitate the functions of the ligands and receptors of biological cells,respectively.Smooth changes in the response current depending on the historical applied voltages are observed,offering a promising pathway toward biorealistic synaptic emulation.The memristive behavior is mainly a result of the interaction between protons provided by chitosan and the defects and functional groups in the rGO nanosheets.The channel current is due to the hopping of protons through functional groups and is limited by the traps in the rGO nanosheets.The transition from short-term to long-term potentiation is achieved,and learning-forgetting behaviors of the memristor mimicking those of the human brain are demonstrated.Overall,the bioinspired memristor-type artificial synaptic device shows great potential in neuromorphic networks. | Qifeng Lu Fuqin Sun Lin Liu Lianhui Li Yingyi Wang Mingming Hao Zihao Wang Shuqi Wang Ting Zhang | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 13 | Efficient sequential harvesting of solar light by heterogeneous hollow shells with hierarchical pores显示文摘In nature,sequential harvesting of light widely exists in the old life entity,i.e.cyanobacteria,to maximize the light absorption and enhance the photosynthesis efficiency.Inspired by nature,we propose a brand new concept of temporally-spatially sequential harvesting of light in one single particle,which has purpose-designed heterogeneous hollow multi-shelled structures(HoMSs)with porous shells composed of nanoparticle subunits.Structurally,HoMSs consist of different band-gap materials outside-in,thus realizing the efficient harvesting of light with different wavelengths.Moreover,introducing oxygen vacancies into each nanoparticle subunit can also enhance the light absorption.With the benefit of sequential harvesting of light in HoMSs,the quantum efficiency at wavelength of 400 nm is enhanced by six times compared with the corresponding nanoparticles.Impressively,using these aforementioned materials as photocatalysts;highly efficient photocatalytic water splitting is realized,which cannot be achieved by using the nanoparticle counterparts.This new concept of temporally-spatially sequential harvesting of solar light paves the way for solving the ever-growing energy demand. | Yanze Wei Jiawei Wan Nailiang Yang Yu Yang Yanwen Ma Songcan Wang Jiangyan Wang Ranbo Yu Lin Gu Lianhui Wang Lianzhou Wang Wei Huang Dan Wang | 2020 | National Science Review2020，7，11： | 2 |
| 14 | Analysis of genetic diversity and population structure of peanut cultivars and breeding lines from China,India and the US using simple sequence repeat markers显示文摘Cultivated peanut is grown worldwide as richsource of oil and protein. A broad genetic base is needed for cultivar improvement. The objectives of this study were to develop highly informative simple sequence repeat(SSR)markers and to assess the genetic diversity and population structure of peanut cultivars and breeding lines from different breeding programs in China, India and the US. A total of 111 SSR markers were selected for this study, resulting in a total of 472 alleles. The mean values of gene diversity and polymorphic information content(PIC) were 0.480 and 0.429, respectively.Country-wise analysis revealed that alleles per locus in three countries were similar. The mean gene diversity in the US,China and India was 0.363, 0.489 and 0.47 with an average PIC of 0.323, 0.43 and 0.412, respectively. Genetic analysis using the STRUCTURE divided these peanut lines into two populations(P_1, P_2), which was consistent with the dendrogram based on genetic distance(G_1, G_2) and the clustering of principal component analysis. The groupings were related to peanut market types and the geographic origin with a few admixtures. The results could be used by breeding programs to assess the genetic diversity of breeding materials to broaden the genetic base and for molecular genetics studies. | Hui Wang Pawan Khera Bingyan.Huang Mei Yuan Ramesh Katam Weijian Zhuang Karen Harris-Shultz Kim M.Moore Albert K.Culbreath Xinyou Zhang Rajeev K.Varshney Lianhui Xie Baozhu Guo | 2016 | Journal of Integrative Plant Biology2016，58，5： | 2 |
| 15 | Genesis of the Weiquan Ag-Polymetallic Deposit in East Tianshan, China: Evidence from Zircon U-Pb Geochronology and C-H-O-S-Pb Isotope Systematics显示文摘The Weiquan Ag-polymetallic deposit is located on the southern margin of the Central Asian Orogenic Belt and in the western segment of the Aqishan-Yamansu arc belt in East Tianshan,northwestern China. Its orebodies, controlled by faults, occur in the lower Carboniferous volcanosedimentary rocks of the Yamansu Formation as irregular veins and lenses. Four stages of mineralization have been recognized on the basis of mineral assemblages, ore fabrics, and crosscutting relationships among the ore veins. Stage I is the skarn stage(garnet + pyroxene), Stage Ⅱ is the retrograde alteration stage(epidote + chlorite + magnetite ± hematite 士 actinolite ± quartz),Stage Ⅲ is the sulfide stage(Ag and Bi minerals + pyrite + chalcopyrite + galena + sphalerite + quartz ± calcite ± tetrahedrite),and Stage IV is the carbonate stage(quartz + calcite ± pyrite). Skarnization,silicification, carbonatization,epidotization,chloritization, sericitization, and actinolitization are the principal types of hydrothermal alteration. LAICP-MS U-Pb dating yielded ages of 326.5±4.5 and 298.5±1.5 Ma for zircons from the tuff and diorite porphyry, respectively. Given that the tuff is wall rock and that the orebodies are cut by a late diorite porphyry dike, the ages of the tuff and the diorite porphyry provide lower and upper time limits on the age of ore formation. The δ^(13)C values of the calcite samples range from-2.5‰ to 2.3‰, the δ^(18)O_(H2 O) and δD_(VSMOW) values of the sulfide stage(Stage Ⅲ) vary from 1.1‰ to 5.2‰ and-111.7‰ to-66.1‰, respectively,and the δ^(13)C, δ^(18)O_(H2 O) and δD_(V-SMOW) values of calcite in one Stage IV sample are 1.5‰,-0.3‰, and-115.6‰, respectively. Carbon, hydrogen, and oxygen isotopic compositions indicate that the ore-forming fluids evolved gradually from magmatic to meteoric sources. The δ^(34)S_(V-CDT) values of the sulfides have a large range from-6.9‰ to 1.4‰, with an average of-2.2‰, indicating a magmatic source, possibly with sedimentary contributions. The ^(206)Pb/^(204)Pb, ^(207)Pb/^(204)Pb, and ^(208)Pb/^(204)Pb ratios of the sulfides are 17.9848-18.2785,15.5188-15.6536, and 37.8125-38.4650, respectively, and one whole-rock sample at Weiquan yields^(206)Pb/^(204)Pb,^(207)Pb/^(204)Pb, and ^(208)Pb/^(204)Pb ratios of 18.2060, 15.5674, and 38.0511,respectively. Lead isotopic systems suggest that the ore-forming materials of the Weiquan deposit were derived from a mixed source involving mantle and crustal components. Based on geological features, zircon U-Pb dating, and C-H-OS-Pb isotopic data, it can be concluded that the Weiquan polymetallic deposit is a skarn type that formed in a tectonic setting spanning a period from subduction to post-collision. The ore materials were sourced from magmatic ore-forming fluids that mixed with components derived from host rocks during their ascent, and a gradual mixing with meteoric water took place in the later stages. | DING Hui GE Wensheng DONG Lianhui ZHANG Liangliang CHEN Xiaodong LIU Yan NIE Junjie | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 2 |
| 16 | Ingeniously designed Ni-Mo-S/ZnIn_(2)S_(4) composite for multi-photocatalytic reaction systems显示文摘Molybdenum disulfide (MoS_(2)) with low cost, high activity and high earth abundance has been found to be a promising catalyst for the hydrogen evolution reaction (HER), but its catalytic activity is considerably limited due to its inert basal planes. Here, through the combination of theory and experiment, we propose that doping Ni in MoS_(2) as catalyst can make it have excellent catalytic activity in different reaction systems. In the EY/TEOA system, the maximum hydrogen production rate of EY/Ni-Mo-S is 2.72 times higher than that of pure EY, which confirms the strong hydrogen evolution activity of Ni-Mo-S nanosheets as catalysts. In the lactic acid and Na_(2)S/Na_(2)SO_(3) systems, when Ni-Mo-S is used as co-catalyst to compound with ZnIn_(2)S_(4) (termed as Ni-Mo-S/ZnIn_(2)S_(4)), the maximum hydrogen evolution rates in the two systems are 5.28 and 2.33 times higher than those of pure ZnIn_(2)S_(4), respectively. The difference in HER enhancement is because different systems lead to different sources of protons, thus affecting hydrogen evolution activity. Theoretically, we further demonstrate that the Ni-Mo-S nanosheets have a narrower band gap than MoS_(2), which is conducive to the rapid transfer of charge carriers and thus result in multi-photocatalytic reaction systems with excellent activity. The proposed atomic doping strategy provides a simple and promising approach for the design of photocatalysts with high activity and stability in multi-reaction systems. | Jing Chen Yumei Tang Shihao Wang Lingbin Xie Cheng Chang Xiaolei Cheng Mingming Liu Longlu Wang Lianhui Wang | 2022 | Chinese Chemical Letters2022，33，3： | 2 |
| 17 | Cleavage of the Babuvirus Movement Protein B4 into Functional Peptides Capable of Host Factor Conjugation is Required for Virulence显示文摘Banana bunchy top virus(BBTV)poses a serious danger to banana crops worldwide.BBTV-encoded protein B4 is a determinant of pathogenicity.However,the relevant molecular mechanisms underlying its effects remain unknown.In this study,we found that a functional peptide could be liberated from protein B4,likely via proteolytic processing.Site-directed mutagenesis indicated that the functional processing of protein B4 is required for its pathogenic effects,including dwarfism and sterility,in plants.The released protein fragment targets host proteins,such as the large subunit of RuBisCO(RbcL)and elongation factor 2(EF2),involved in protein synthesis.Therefore,the peptide released from B4(also a precursor)may act as a non-canonical modifier to influence host-pathogen interactions involving BBTV and plants. | Jun Zhuang Wenwu Lin Christopher J.Coates Pengxiang Shang Taiyun Wei Zujian Wu Lianhui Xie | 2019 | Virologica Sinica2019，34，3： | 1 |
| 18 | Hydrotreating of light cycled oil using WNi/Al2O3 catalysts containing zeolites be- ta and/or chemically treated zeolite Y 显示文摘 | Lianhui Ding Ying Zheng Zisheng Zhang | 2006 | Journal of Catalysis2006，241，2： | 1 |
| 19 | Bio-inspired flexible artificial synapses for pain perception and nerve injuries显示文摘Imitation of the perception system of living creatures is of great importance for the construction of artificial nerves and intelligent human-machine interfaces.However,a prominent challenge is to emulate the functions of the biological synapse,which is the basic building block of the neural system.Here,inspired by the pain perception mechanism of the living creatures,a flexible double-layer memristor was constructed,with 90%semiconducting single-wall carbon nanotubes(s-SWCNTs)covered by LiClO4 doped polyoxyethylene oxide(PEO:LiClO4)as the channel materials.The carriers(protons and Li+)from PEO:LiClO4 imitated the functions of Na+and K+in biological systems.A potentiation of the post-synaptic signal was observed with mild stimuli,while the post-synaptic signal was inhibited with severe stimuli with a pulse voltage larger than 1.4 V in this research.These behaviors resemble the sensation of pain,neuroprotection,and possible injuries to the neural system.To explore the underlying mechanism of the phenomenon,the fourier-transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS),Raman spectrum,and current(IV)sweep were carried out.It was inferred that the observed results are attributable to the interaction between carriers in PEO:LiClO4 and functional groups and defects in the s-SWCNTs.The enhanced channel current results from the fulfillment of the traps by the carriers,and the suppression of the current is due to the intercalation of Li+in the s-SWCNTs.This flexible artificial synapse opens a new avenue for the construction of biocompatible electronic devices towards artificial intelligence systems. | Qifeng Lu Fuqin Sun Lin Liu Lianhui Li Mingming Hao Zihao Wang Ting Zhang | 2020 | npj Flexible Electronics2020，4，1： | 1 |
| 20 | “Top-down” and “bottom-up” strategies for wafer-scaled miniaturized gas sensors design and fabrication显示文摘Manufacture of large-scale patterned nanomaterials via top-down techniques,such as printing and slurry coating,have been used for fabrication of miniaturized gas sensors.However,the reproducibility and uniformity of the sensors in wafer-scale fabrication are still a challenge.In this work,a“top-down”and“bottom-up”combined strategy was proposed to manufacture wafer-scaled miniaturized gas sensors with high-throughput by in-situ growth of Ni(OH)2 nanowalls at specific locations.First,the micro-hotplate based sensor chips were fabricated on a two-inch(2″)silicon wafer by micro-electro-mechanical-system(MEMS)fabrication techniques(“top-down”strategy).Then a template-guided controllable de-wetting method was used to assemble a porous thermoplastic elastomer(TPE)thin film with uniform micro-sized holes(relative standard deviation(RSD)of the size of micro-holes<3.5%,n>300),which serves as the patterned mask for in-situ growing Ni(OH)2 nanowalls at the micro-hole areas(“bottom-up”strategy).The obtained gas microsensors based on this strategy showed great reproducibility of electric properties(RSD<0.8%,n=8)and sensing response toward real-time H _(2)S detection(RSD<3.5%,n=8). | Lin Liu Yingyi Wang Fuqin Sun Yanbing Dai Shuqi Wang Yuanyuan Bai Lianhui Li Tie Li Ting Zhang Sujie Qin | 2020 | Microsystems & Nanoengineering2020，6，1： | 1 |
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