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| 1 | Identification of Pns12 as the second silencing suppressor of Rice gall dwarf virus显示文摘RNA silencing is a conserved mechanism found ubiquitously in eukaryotic organisms.It has been used to regulate gene expression and development.In addition,RNA silencing serves as an important mechanism in plants' defense against invasive nucleic acids,such as viruses,transposons,and transgenes.As a counter-defense,most plants,and some animal viruses,encode RNA silencing suppressors to interfere at one or several points of the silencing pathway.In this study,we showed that Pns12 of RGDV (Rice gall dwarf virus) exhibits silencing suppressor activity on the reporter green fluorescent protein in transgenic Nicotiana benthamiana line 16c.Pns12 of RGDV suppressed local silencing induced by sense RNA but had no effect on that induced by dsRNA.Expression of Pns12 also enhanced Potato virus X pathogenicity in N.benthamiana.Collectively,these results suggested that RGDV Pns12 functions as a virus suppressor of RNA silencing,which might target an upstream step of dsRNA formation in the RNA silencing pathway.Furthermore,we showed that Pns12 is localized mainly in the nucleus of N.benthamiana leaf cells. | WU JianGuo WANG ChunZheng DU ZhengGuo CAI LiJun HU MeiQun WU ZuJian LI Yi XIE LianHui | 2011 | Science China(Life Sciences)2011，54，3： | 7 |
| 2 | Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections显示文摘The formation of bacterial biofilms closely associates with infectious diseases.Until now,precise diagnosis and effective treatment of bacterial biofilm infections are still in great need.Herein,a novel multifunctional theranostic nanoplatform based on MnO_(2)nanosheets(MnO_(2)NSs)has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy(aPDT)of bacterial biofilm infections.In this study,MnO_(2)NSs were modified with bovine serum albumin(BSA)and polyethylene glycol(PEG)and then loaded with chlorin e_(6)(Ce_(6))as photosensitizer to form MnO_(2)-BSA/PEG-Ce_(6)nanosheets(MBP-Ce_(6)NSs).After being delivered into the bacterial biofilm-infected tissues,the MBP-Ce_(6)NSs could be decomposed in acidic biofilm microenvironment and release Ce_(6)with Mn^(2+),which subsequently activate both fluorescence(FL)and magnetic resonance(MR)signals for effective dual-mode FL/MR imaging of bacterial biofilm infections.Meanwhile,MnO_(2)could catalyze the decomposing of H2O_(2)in biofilm-infected tissues into O_(2)and relieve the hypoxic condition of biofilm,which significantly enhances the efficacy of aPDT.An in vitro study showed that MBP-Ce_(6)NSs could significantly reduce the number of methicillin-resistant Staphylococcus aureus(MRSA)in biofilms after 635nm laser irradiation.Guided by FL/MR imaging,MRSA biofilm-infected mice can be efficiently treated by MBP-Ce_(6)NSs-based aPDT.Overall,MBP-Ce_(6)NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm,which provides a promising theranostic nanoplatform for bacterial biofilm infections. | Weijun Xiu Siyu Gan Qirui Wen Qiu Qiu Sulai Dai Heng Dong Qiang Li Lihui Yuwen Lixing Weng Zhaogang Teng Yongbin Mou Lianhui Wang | 2020 | Research2020，，1： | 7 |
| 3 | Effects of deformation twins on microstructure evolution,mechanical properties and corrosion behaviors in magnesium alloys-A review显示文摘Due to lattice reorientation,grain segmentation,induced recrystallization,twins play a very important role in regulating texture,refining grains,improving mechanical properties and corrosion resistance,and has received more extensive attention.Numerous studies have shown that{10-12}<10-11>tensile twins(TTWs)are easily activated in large quantities due to the lower critical resolve shear stresses(CRSS).Introduction of TTWs under uniaxial compression improved the strength,ductility,and formability of magnesium(Mg)alloys.Moreover,TTWs produced by multi-directional impact forging(MDIF)can optimize the microstructure by dividing grains and promoting recrystallization,resulting in significant improvement of mechanical properties.Although{10-11}<10-12>compressive twins(CTWs)and{10-11}-{10-12}double twins(DTWs)can promote dynamic recrystallization(DRX),they are also favorable nucleation sites for cracks.In addition,the type and volume fraction of twins can affect the corrosion resistance,and they also play different roles in the corrosion process of different Mg alloys.Twins have shown great potential for improving structure and properties,but a comprehensive and critical discussion of twins in Mg alloys is still lacking.Therefore,based on previous studies,this article reviews the common types and variants of twins in Mg alloys,influencing factors,and their effects on the microstructure,mechanical properties and corrosion resistance.In addition,some interesting ideas are being proposed for further research. | Lianhui Li Wenhong Liu Fugang Qi Di Wu Zhiqiang Zhang | 2022 | Journal of Magnesium and Alloys2022，10，9： | 5 |
| 4 | The TAK1-JNK cascade is required for IRF3 function in the innate immune response显示文摘干扰素规章的因素(IRF ) 3 在病毒或细菌的侵略期间为 chemokines 和 cytokines 的 transcriptional 正式就职是批评的。kinases 坦克有约束力的 kinase (TBK ) 1 并且 Ikappa B kinase (IKK ) 蔚罐头 phosphorylate IRF3 和玩的 C 终端部分在 IRF3 激活的重要角色。在这研究,我们显示出那另外一个 kinase, c-Jun-NH2-terminal kinase (JNK ) ,它的 N 终端丝氨酸上的 phosphorylates IRF3 173 残余,和 TAK1 能经由 JNK 刺激 IRF3 phosphorylation。没有影响 C 终端 phosphorylation, JNK 特定的禁止者 SP600125 禁止 N 终端 phosphorylation。另外, lipopolysaccharide (LPS ) 上的调停 IRF3 的基因表情或 polyinosinic-cytidylic 酸(polyI : C ) 处理被 SP600125 严重地损害,以及为 IRF3 激活的记者基因试金。进一步证实的 TAK1 击倒这些观察。有趣地,组成的活跃 IRF3 (5D ) 能被 SP600125 禁止;JNK1 罐头 synergize IRF3 (5D ) 的行动,然而并非 S173A-IRF3 (5D ) 变异。更重要地, polyI : 没能戏剧性地导致变异的 S173A 和 SP600125 的 phosphorylation 的 C 废除了被 polyI 刺激的 IRF3 phosphorylation 和 dimerization : C。因此,这研究证明 TAK1-JNK 串联为 IRF3 功能被要求,除了 TBK1/IKK 蔚,揭开为激活 mitogen 的蛋白质(地图) 的新机制调整天生的免疫的 kinase。 | Bianhong Zhang Meng Li Liang Chen Kai Yang Yufei Shan Lianhui Zhu Shaogang Sun Lin Li Chen Wang | 2009 | Cell Research2009，19，4： | 4 |
| 5 | Single-Step Organization of Plasmonic Gold Metamaterials with Self-Assembled DNA Nanostructures显示文摘Self-assembled DNA nanostructures hold great promise as nanoscale templates for organizing nanoparticles(NPs)with nearatomistic resolution.However,large-scale organization of NPs with high yield is highly desirable for nanoelectronics and nanophotonic applications.Here,we design fve-strand DNA tiles that can readily self-assemble into well-organized micrometerscale DNA nanostructures.By organizing gold nanoparticles(AuNPs)on these self-assembled DNA nanostructures,we realize the fabrication of one-and two-dimensional Au nanostructures in single steps.We further demonstrate the one-pot synthesis of Au metamaterials for highly amplifed surface-enhanced Raman Scattering(SERS).Tis single-step and high-yield strategy thus holds great potential for fabricating plasmonic metamaterials. | Shaokang Ren Jun Wang Chunyuan Song Qian Li Yanjun Yang Nan Teng Shao Su Dan Zhu Wei Huang Jie Chao Lianhui Wang Chunhai Fan | 2019 | Research2019，，1： | 4 |
| 6 | A Nano-and Micro-Integrated Protein Chip Based on Quantum Dot Probes and a Microfluidic Network显示文摘A novel nano-and micro-integrated protein chip(NMIPC)that can detect proteins with ultrahigh sensitivity has been fabricated.A microfl uidic network(μFN)was used to construct the protein chips,which allowed facile patterning of proteins and subsequent biomolecular recognition.Aqueous phase-synthesized,water-soluble fl uorescent CdTe/CdS core-shell quantum dots(aqQDs),having high quantum yield and high photostability,were used as the signaling probe.Importantly,it was found that aqQDs were compatible with microfluidic format assays,which afforded highly sensitive protein chips for cancer biomarker assays. | Juan Yan Mei Hu Di Li Yao He Rui Zhao Xingyu Jiang Shiping Song Lianhui Wang Chunhai Fan | 2008 | Nano Research2008，1，6： | 3 |
| 7 | Investigation on microstructures and mechanical properties of Mg-6Zn-0.5Ce-xMn(x=0 and 1)wrought magnesium alloys显示文摘The microstructure evolution and mechanical properties of Mg–6Zn–0.5Ce–xMn(x=0 and 1 wt.%)wrought magnesium alloys were researched,and the morphologies and role of Mn element in the experimental alloys were analyzed.The research shows that all of Mn elements form theα-Mn pure phases,which do not participate in the formation of other phases,such as theτ-phases.The mechanical properties of Mn-containing alloys in as-extruded and aged states are superior to Mn-free alloys.During the hot extrusion process,the dispersed fineα-Mn particle phase hinders the migration of grain boundaries and inhibits dynamic recrystallization,which mainly takes effect of grain refining and dispersion hardening.During the aging treatments,the dispersed fineα-Mn particle phase not only hinders the growth of the solution-treated grains,but also becomes the nucleation cores ofβ1 rod-like precipitate phase,which is conducive to increasing the nucleation rate of the precipitate phase.For the aged alloy,the Mn addition mainly takes effect of grain refining and promoting aging strengthening. | Caihong Hou Hongshuai Cao Fugang Qi Qing Wang Lianhui Li Nie Zhao Dingfei Zhang Xiaoping Ouyang | 2022 | Journal of Magnesium and Alloys2022，10，4： | 3 |
| 8 | Biological receptor-inspired flexible artificial synapse based on ionic dynamics显示文摘The memristor has been regarded as a promising candidate for constructing a neuromorphic computing platform that is capable of confronting the bottleneck of the traditional von Neumann architecture.Here,inspired by the working mechanism of the G-protein-linked receptor of biological cells,a novel double-layer memristive device with reduced graphene oxide(rGO)nanosheets covered by chitosan(an ionic conductive polymer)as the channel material is constructed.The protons in chitosan and the functional groups in rGO nanosheets imitate the functions of the ligands and receptors of biological cells,respectively.Smooth changes in the response current depending on the historical applied voltages are observed,offering a promising pathway toward biorealistic synaptic emulation.The memristive behavior is mainly a result of the interaction between protons provided by chitosan and the defects and functional groups in the rGO nanosheets.The channel current is due to the hopping of protons through functional groups and is limited by the traps in the rGO nanosheets.The transition from short-term to long-term potentiation is achieved,and learning-forgetting behaviors of the memristor mimicking those of the human brain are demonstrated.Overall,the bioinspired memristor-type artificial synaptic device shows great potential in neuromorphic networks. | Qifeng Lu Fuqin Sun Lin Liu Lianhui Li Yingyi Wang Mingming Hao Zihao Wang Shuqi Wang Ting Zhang | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 9 | Bio-inspired flexible artificial synapses for pain perception and nerve injuries显示文摘Imitation of the perception system of living creatures is of great importance for the construction of artificial nerves and intelligent human-machine interfaces.However,a prominent challenge is to emulate the functions of the biological synapse,which is the basic building block of the neural system.Here,inspired by the pain perception mechanism of the living creatures,a flexible double-layer memristor was constructed,with 90%semiconducting single-wall carbon nanotubes(s-SWCNTs)covered by LiClO4 doped polyoxyethylene oxide(PEO:LiClO4)as the channel materials.The carriers(protons and Li+)from PEO:LiClO4 imitated the functions of Na+and K+in biological systems.A potentiation of the post-synaptic signal was observed with mild stimuli,while the post-synaptic signal was inhibited with severe stimuli with a pulse voltage larger than 1.4 V in this research.These behaviors resemble the sensation of pain,neuroprotection,and possible injuries to the neural system.To explore the underlying mechanism of the phenomenon,the fourier-transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS),Raman spectrum,and current(IV)sweep were carried out.It was inferred that the observed results are attributable to the interaction between carriers in PEO:LiClO4 and functional groups and defects in the s-SWCNTs.The enhanced channel current results from the fulfillment of the traps by the carriers,and the suppression of the current is due to the intercalation of Li+in the s-SWCNTs.This flexible artificial synapse opens a new avenue for the construction of biocompatible electronic devices towards artificial intelligence systems. | Qifeng Lu Fuqin Sun Lin Liu Lianhui Li Mingming Hao Zihao Wang Ting Zhang | 2020 | npj Flexible Electronics2020，4，1： | 1 |
| 10 | “Top-down” and “bottom-up” strategies for wafer-scaled miniaturized gas sensors design and fabrication显示文摘Manufacture of large-scale patterned nanomaterials via top-down techniques,such as printing and slurry coating,have been used for fabrication of miniaturized gas sensors.However,the reproducibility and uniformity of the sensors in wafer-scale fabrication are still a challenge.In this work,a“top-down”and“bottom-up”combined strategy was proposed to manufacture wafer-scaled miniaturized gas sensors with high-throughput by in-situ growth of Ni(OH)2 nanowalls at specific locations.First,the micro-hotplate based sensor chips were fabricated on a two-inch(2″)silicon wafer by micro-electro-mechanical-system(MEMS)fabrication techniques(“top-down”strategy).Then a template-guided controllable de-wetting method was used to assemble a porous thermoplastic elastomer(TPE)thin film with uniform micro-sized holes(relative standard deviation(RSD)of the size of micro-holes<3.5%,n>300),which serves as the patterned mask for in-situ growing Ni(OH)2 nanowalls at the micro-hole areas(“bottom-up”strategy).The obtained gas microsensors based on this strategy showed great reproducibility of electric properties(RSD<0.8%,n=8)and sensing response toward real-time H _(2)S detection(RSD<3.5%,n=8). | Lin Liu Yingyi Wang Fuqin Sun Yanbing Dai Shuqi Wang Yuanyuan Bai Lianhui Li Tie Li Ting Zhang Sujie Qin | 2020 | Microsystems & Nanoengineering2020，6，1： | 1 |
| 11 | Synthesis of a MnO 2 –graphene foam hybrid with controlled MnO 2 particle shape and its use as a supercapacitor electrode显示文摘 | Xiaochen Dong Xuewan Wang Jing Wang Hao Song Xingao Li Lianhui Wang Mary B. Chan-Park Chang Ming Li Peng Chen | 2012 | Carbon2012，，： | 1 |
| 12 | of polyurethane foams corn stover with PAPI 显示文摘 | Tipeng Wang Lianhui Mechanical properties prepared from liquefied Zhang Dong Li | 2008 | Bioresource Technology2008，99，7： | 1 |
| 13 | Mechanical properties of polyurethane foams prepared from liquefied corn stover with PAPI显示文摘 | Wang Tipeng Zhang Lianhui Li Dong | 2008 | Bioresource Techn2008，99，7： | 1 |
| 14 | Effect of steam explosion on biodegradation of lignin in wheat straw显示文摘 | Zhang Lianhui Li Dong Wan Lijung | 2008 | Bioresource Technology2008，99，18： | 1 |
| 15 | Isolation and production of artemisinin and stigmasterol in hairy root cultures of Artemisia annua显示文摘 | Deyu Xie Lianhui Wang Hechun Ye Guofeng Li | | Plant Cell Tissue and Organ Culture0，，： | 1 |
| 16 | Stretchable,self-healing,transient macromolecular elastomeric gel for wearable electronics显示文摘Flexible and stretchable electronics are emerging in mainstream technologies and represent promising directions for future lifestyles.Multifunctional stretchable materials with a self-healing ability to resist mechanical damage are highly desirable but remain challenging to create.Here,we report a stretchable macromolecular elastomeric gel with the unique abilities of not only self-healing but also transient properties at room temperature.By inserting small molecule glycerol into hydroxyethylcellulose(HEC),forming a glycerol/hydroxyethylcellulose(GHEC)macromolecular elastomeric gel,dynamic hydrogen bonds occur between the HEC chain and the guest small glycerol molecules,which endows the GHEC with an excellent stretchability(304%)and a self-healing ability under ambient conditions.Additionally,the GHEC elastomeric gel is completely water-soluble,and its degradation rate can be tuned by adjusting the HEC molecular weight and the ratio of the HEC to glycerol.We demonstrate several flexible and stretchable electronics devices,such as self-healing conductors,transient transistors,and electronic skins for robots based on the GHEC elastomeric gel to illustrate its multiple functions. | Mingming Hao Lianhui Li Shuqi Wang Fuqin Sun Yuanyuan Bai Zhiguang Cao Chunyan Qu Ting Zhang | 2019 | Microsystems & Nanoengineering2019，5，1： | 1 |
| 17 | Mechanical properties of polyurethane foams prepared from liquefied corn stover with PAPI显示文摘 | Wang Tipeng Zhang Lianhui Li Dong | 2008 | Bioresour Techn2008，99，7： | 1 |
| 18 | Synthesis, Structural Characterization and Reactivity of a Bis(phosphine)(silyl) Platinum(ll) Complex显示文摘1,2-C 6有磅( dmpe )的 H 4(SiH3)(SiH3)( 1 )(宠物3)2( dmpe=Me 2 PCH 2 CH 2在 1:1 的比率的 PMe 2)导致建筑群{ 1,2-C 6 H 4(SiH2)(SiH2)}Pt II ( dmpe )( 2 ),它能与与低位的阻碍者生 hydroxy 组形成 tetra-alkoxy 的器官的试剂代替了的质子反应 silyl 铂( II )化合物( 3 )。加重 2 和 3 silyl 转变金属建筑群的稀罕例子从这 chelating hydrosilane ligand 被导出。就我们的知识而言,仅仅有从这 ligand 准备,如此的结构的特征登记在剑桥结构的数据库的 silyl 金属建筑群的 6 个例子,在他们之中,一仅仅 silyl 铂(II ) 混合物被介绍。建筑群的结构 2 和 3 被 multinuclear NMR 分光镜的研究和单个水晶 X 光检查分析明白地决定。 | Yonghua Li Wenjin Zeng Wenyong Lai Shigeru Shimada Shi Wang Lianhui Wang Wei Huang | 2015 | Chinese Journal of Chemistry2015，33，10： | 0 |
| 19 | Multifunctional shape-dependent plasmonic nanoprobe by enzymatic etching of single gold triangular nanoplate显示文摘Hydrogen peroxide(H2O2),as a signaling molecule,plays a vital role in a wide variety of signaling transduction processes,aging,and diseases.However,the excessive production of H2O2 causes various diseases.Herein,we develop a novel method for H2O2 detection in live cells via dark-field scattering spectroscopy with gold triangular nanoprisms(AuTNPs)as probes.The corners of AuTNPs would be gradually oxidatively etched by the strong coordination of Br•which is generated by enzymatic reactions in the presence of horseradish peroxidase(HRP),bromide ion and trace hydrogen peroxide.Benefitting from the morphological change,the single AuTNP based plasmonic nanoprobe shows notable blueshifts and scattering color changes which could be real-time monitored under the dark-field microscopy.The peak position in the scattering spectra of individual AuTNP blueshifts linearly with the increase of H2O2 concentration,and exhibits high sensitivity to H2O2 in a large range from 2.5 to 100µM with a low detection limit(LOD)of 0.74µM.Moreover,the experimental results were supported by the simulated results via the finite-difference time-domain(FDTD)method.The nanoprobes have been further used for intracellular H2O2 detection in live cells.Besides,the etching of AuTNP also provides an alternative method to design novel plasmonic logic chips and write-once plasmonic memories. | Ning Feng Jingjing Shen Yu Chen Chang Li Yanling Hu Lei Zhang Shufen Chen Quli Fan Wei Huang Lianhui Wang | 2020 | Nano Research2020，13，12： | 0 |
| 20 | Text duplication of papers in four medical related fields显示文摘Purpose:To reveal the typical features of text duplication in papers from four medical fields:basic medicine,health management,pharmacology and pharmacy,and public health and preventive medicine.To analyze the reasons for duplication and provide suggestions for the management of medical academic misconduct.Design/methodology/approach:In total,2,469 representative Chinese journal papers were included in our research,which were submitted by researchers in 2020 and 2021.A plagiarism check was carried out using the Academic Misconduct Literature Check System(AMLC).We generated a corrected similarity index based on the AMLC general similarity index for further analysis.We compared the similarity indices of papers in four medical fields and revealed their trends over time;differences in similarity index between review and research articles were also analyzed according to the different fields.Further analysis of 143 papers suspected of plagiarism was also performed from the perspective of sections containing duplication and according to the field of research.Findings:Papers in the field of pharmacology and pharmacy had the highest similarity index(8.67±5.92%),which was significantly higher than that in other fields,except health management.The similarity index of review articles(9.77±10.28%)was significantly higher than that of research articles(7.41±6.26%).In total,143 papers were suspected of plagiarism(5.80%)with similarity indices≥15%;most were papers on health management(78,54.55%),followed by public health and preventive medicine(38,26.58%);90.21%of the 143 papers had duplication in multiple sections,while only 9.79%had duplication in a single section.The distribution of sections with duplication varied among different fields;papers in pharmacology and pharmacy were more likely to have duplication in the data/methods and introduction/background sections,however,papers in health management were more likely to contain duplication in the introduction/background or results/discussion sections.Different structures for papers in different fields may have caused these differences.Research limitations:There were three limitations to our research.Firstly,we observed that a small number of papers have been checked early.It is unknown who conducted the plagiarism check as this can be included in other evaluations,such as applications for Science and technology projects or awards.If the authors carried out the check,text with high similarity indices may have been excluded before submission,meaning the similarity index in our research may have been lower than the original value.Secondly,there were only four medical fields included in our research.Additional analysis on a wider scale is required in the future.Thirdly,only a general similarity index was calculated in our study;other similarity indices were not tested.Practical implications:A comprehensive analysis of similarity indices in four medical fields was performed.We made several recommendations for the supervision of medical academic misconduct and the formation of criteria for defining suspected plagiarism for medical papers,as well as for the improved accuracy of text duplication checks.Originality/value:We quantified the differences between the AMLC general similarity index and the corrected index,described the situation around text duplication and plagiarism in papers from four medical fields,and revealed differences in similarity indices between different article types.We also revealed differences in the sections containing duplication for papers with suspected plagiarism among different fields. | Ping Ni Lianhui Shan Yong Li Xinying An | 2023 | Journal of Data and Information Science2023，8，4： | 0 |
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