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| 1 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。 | Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang | 2013 | Cell Research2013，23，8： | 26 |
| 2 | Multiresidue method for the determination of sulfonamides in pork tissue 显示文摘 | Austin R Long Lily C Hsieh | 1990 | J Agile Food Chem1990，38，： | 1 |
| 3 | T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity显示文摘 | Huaizhu Wu Sudip Ghosh Xiaoyuan Dai Perrard Lili Feng Gabriela E. Garcia Jerry L. Perrard John F. Sweeney Leif E. Peterson Lawrence Chan C Wayne Smith Christie M. Ballantyne | 2007 | Circulation2007，，8： | 1 |
| 4 | Anticholinergic and antiglutamatergic agents protect against Soman-induced brain damage and cognitive dysfunction显示文摘 | Lily R Ben A W Giora C | 2003 | Toxicol Sci2003，75，： | 1 |
| 5 | Evaluations of output from room acoustic computer modeling and auralization due to different sound source directionalities 显示文摘 | Lily M Wang Michelle C Vigeant | 2008 | Applied Acoustics2008，，69： | 1 |
| 6 | The activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cells显示文摘 | Lili L Shang Z Xue C | | 0，，05： | 1 |
| 7 | Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase显示文摘 | Lily N Goodyear R J Woods C A | 2004 | PlaZAS2004，101，10： | 1 |
| 8 | Practi-cal routing in delay-tolerant networks显示文摘 | Jones Evan P C Li Lily Schmidtke Jakub K | 2007 | IEEE Transac-tions on Mobile Computing2007，6，8： | 1 |
| 9 | Protein modulator of muhidrug efflux gene expression in Pseudomonas aeruginosa 显示文摘 | Denis MD Lily C Sebastien F | 2007 | J Bacteriol2007，189，15： | 1 |
| 10 | Changes in coagulation and hemody- namics during pregnancy:a prospective longitudinal study of 58 ea- ses 显示文摘 | Hui C Lili M Libin C | 2012 | Arch Gynecol Obstet2012，285，12： | 1 |
| 11 | Leaming user similarity and rating style for collaborative recommendation显示文摘 | Kwok-Wai C Lily F T | 2004 | Information Retrieval2004，7，34： | 1 |
| 12 | Ion channel genes and human neurological disease: Recent progress, prospects and challenges显示文摘 | Edward C Cooper Lily YJ | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 13 | Application of a Design-for- remanufacture Framework to the Selection of Product l,ife- cycle Fastening and Joining Methods 显示文摘 | Shu Lily H Flowers Woodie C | 1999 | Robotics and Computer Integrated Manufacturing1999，15，3： | 1 |
| 14 | Immunobichemical and molecular biologic characterization of the cell proliferation associated unclear antigen that is defined by monoclonal antibody ki-67显示文摘 | Gerdes J LiLi Schlueter C | 1991 | Am J Pathol1991，138，4： | 1 |
| 15 | Plasm homocysteine as a rist factor for early family coronery artery disease显示文摘 | LILY L W JAMES W STEVEN C H | 1994 | Clin Chem1994，40，4： | 1 |
| 16 | Novel active heterogeneous Fenton system based on Fe3-~M~O4 (Fe,Co,Mn,Ni) :The role of Mz+ spe- cies on the reactivity towards HzOz reactions显示文摘 | COSTA R C C LILIS M F F OLIVEIRA L C A | 2006 | Journal of Hazardous Materials2006，129，13： | 1 |
| 17 | Application of a Design-for- remanufacture Framework to the Selection of Product Lifecycle Fastening and Joining Methods 显示文摘 | Shu Lily I-I Flowers Woodie C | 1999 | Robotics and Computer Integrated Manufacturing1999，，15： | 1 |
| 18 | Effect of terrain on foot pressures during walking显示文摘 | OLFAT M KAY C LILY H | 2000 | Diabetes Care2000，22，： | 1 |
| 19 | Changes in coagulation and hemodynamics during pregnancy:a prospective longitudi- nal study of 58 cases 显示文摘 | Hui C Lili M Libin C | 2012 | Arch Gynecol Obstet2012，285，5： | 1 |
| 20 | Evaluation of advanced reverse respiratory syndrome associated coronavirus transcription-PCR assays and an alternative PCR target region for detection of severe acute显示文摘 | Christian D Lily C Marcus P | 2004 | JOURNAL OF CLINICAL MICROBIOLOGY2004，42，5： | 1 |
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