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| 1 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 2 | Geochemical and isotopic characteristics of volcanic rocks from the northern East China Sea shelf margin and the Okinawa Trough显示文摘Volcanic rocks both from the northern East China Sea (NECS) shelf margin and the northern Okinawa Trough are subalkaline less aluminous,and lower in High Field Strength Elements (HFSE).These rocks are higher in Large Ion Lithophile Elements (LILE),thorium and uranium contents,positive lead anomalies,negative Nb-Ta anomalies,and enrichment in Light Rare Earth Elements (LREE).Basalts from the NECS shelf margin are akin to Indian Ocean Mid-Ocean Ridge Basalt (MORB),and rhyolites from the northern Okinawa Trough have the highest 207 Pb/ 204 Pb and 208 Pb/ 204 Pb ratios.The NECS shelf margin basalts have lower 87 Sr/ 86 Sr ratios,ε N d and σ 18 O than the northern Okinawa Trough silicic rocks.According to 40 K– 40 Ar isotopic ages of basalts from the NECS shelf margin,rifting of the Okinawa Trough may have been active since at least 3.65–3.86 Ma.The origin of the NECS shelf margin basalt can be explained by the interaction of melt derived from Indian Ocean MORB-like mantle with enriched subcontinental lithosphere.The basalts from both sides of the Okinawa Trough may have a similar origin during the initial rifting of the Okinawa Trough,and the formation of basaltic magmas closely relates to the thinning of continental crust.The source of the formation of the northern Okinawa Trough silicic rocks was different from that of the middle Okinawa Trough,which could have been generated by the interaction of basaltic melt with an enriched crustal component.From the Ryukyu island arc to East China,the Cenozoic basalts have apparently increasing trends of MgO contents and ratios of LREE to Heavy Rare Earth Elements (HREE),suggesting that the trace element variabilities of basalts may have been influenced by the subduction of the Philippine Sea plate,and that the effects of subduction of the Philippine Sea plate on the chemical composition of basaltic melts have had a decreasing effect from the Ryukyu island arc to East China. | ZENG Zhigang YU Shaoxiong WANG Xiaoyuan FU Yongtao YIN Xuebo ZHANG Guoliang WANG Xiaomei CHEN Shuai | 2010 | Acta Oceanologica Sinica2010，29，4： | 19 |
| 3 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 4 | Research and application of enterprise resource planning system for foundry enterprises显示文摘PPDB issues-four aspects of current management issues of foundry enterprises are discussed in this paper,including Production Management,Process Control,Duration Monitoring and Business Intelligence Data Analysis.Also a whole Enterprise Resource Planning(ERP) solution for foundry enterprises is proposed.The solution contains many models,four of which are used to solve the PPDB issues.These are called SPDB models,which separately are the Single-piece management model(based on casting lifecycle),Process management model(based on task-driven technology),Duration monitoring model(based on surplus period),and Business intelligence data analysis model(based on data mining).An ERP system for foundry enterprises,named HZERP,was researched and developed,and applied to a sand casting company of single piece and small batch production.Qualitatively and quantitatively comparing the application effect before and after implementing the HZERP system,the result demonstrated that the foundry ERP system based on the SPDB models can help metal casting enterprises achieve the single-piece management,better regulate the production processes,improve production and delivery management,shorten the production cycle,reduce costs,and speed up the capital turnover to a large extent. | Zhou Jianxin Ji Xiaoyuan Liao Dunming Guan Bifeng Guan Bihong Pang Shengyong Tang Hongtao | 2013 | China Foundry2013，10，1： | 16 |
| 5 | No association between elevated homocysteine levels and carotid atherosclerosis in a rural population in China显示文摘Objectives:We wish to determine if homocysteine(Hcy)is an independent risk factor for carotid atherosclerosis in a rural Chinese population.Methods:2291 individuals(1016 men and 1275 women),aged 64.6±7.4 years,from Lvliang,China participated in this study.Tests performed included carotid artery ultrasound scan and blood analysis,to measure Hcy levels and other blood components.Results:The mean serum Hcy level was 24.7±18.0μmol/L.The overall detection rate of carotid atherosclerotic lesions was 76.3%and the detection rate of plaque was 48.6%.Participants were divided into 4 groups based on their Hcy levels,<14.49,14.49–19.43,19.44–28.30,and≥28.30μmol/L.The relative risk of carotid atherosclerosis for each quartile as compared with the risk for the lowest quartile was estimated as the OR derived from the logistic regression coefficients.After adjusting for age and gender,the OR of carotid atherosclerosis in the third and fourth quartiles of Hcy were 1.219(95%CI 0.922 to 1.612)and 1.156(95%CI 0.859 to 1.555;p>0.05),respectively.After controlling for demographic variables(age,gender,current smoker,fasting blood glucose,low-density lipoprotein and systolic blood pressure)the OR of carotid plaque(s)in the third and fourth quartiles were 1.246(95%CI 0.967 to 1.606)and 1.259(95%CI 0.963 to 1.646;p>0.05).Conclusions:The mean value of Hcy among participants in this study was much higher than that previously reported.However,no significant correlation between elevated Hcy and carotid atherosclerosis was found. | Yang Li Li Wang Wei Zhang Yalan Fang Xiaoyuan Niu | 2016 | Stroke & Vascular Neurology2016，1，4： | 13 |
| 6 | Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stern cell generation显示文摘 | Xiaoyuan Wei Yueting Chen Yongyu Xu YangZhan Ru Zhang Min Wang Qiuhong Hua Haifeng Gu Fajun Nan Xin Xie | 2014 | Journal of Molecular Cell Biology2014，8，5： | 13 |
| 7 | Formation of Fe-oxyhydroxides from the East Pacific Rise near latitude 13°N:Evidence from mineralogical and geochemical data显示文摘The mineralogical and geochemical characteristics of Fe-oxyhydroxide samples from one dredge station (long. 103°54.48'W, lat. 12°42.30'N, water depth 2655 m) on the East Pacific Rise near lat 13°N were analyzed by XRD, ICP-AES, and ICP-MS. Most Fe-oxyhydroxides are amorphous, with a few sphalerite microlites. In comparison with Fe-oxyhydroxides from other fields, the variable ranges in the chemical composition of Fe-oxyhydroxide samples are very narrow; their Fe, Si, and Mn contents were 39.90%, 8.92%, and 1.59%, respectively; they have high Cu (0.88%―1.85%) and Co (65×10?6―704×10?6) contents, and contain Co+Cu+Zn+Ni> 1.01%. The trace-element (As, Co, Ni, Cu, Zn, Ba, Sr) and major-element (Fe, Ca, Al, Mg) contents of these samples are in the range of hydrothermal sulfide from the East Pacific Rise near 13°N, reflecting that this type of Fe-oxyhydroxide constitutes a secondary oxidation product of hydrothermal sulfide. The Fe-oxyhydroxide samples from one dredge station on the East Pacific Rise near 13°N are lower in ΣREE (5.44×10?6―17.01×10?6), with a distinct negative Ce anomaly (0.12 ― 0.28). The Fe-oxyhydroxide samples have similar chondrite-normalized rare-earth-element (REE) patterns to that of seawater, and they are very different from the REE composition characteristics of hydrothermal plume particles and hydrothermal fluids, showing that the REEs of Fe-oxyhydroxide are a major constituent of seawater and that the Fe-oxyhydroxides can become a sink of REE from seawater. The quick settling of hydrothermal plume particles resulted in the lower REE content and higher Mn content of these Fe-oxyhydroxides, which are captured in part of the V and P from seawater by adsorption. The Fe-oxyhydroxides from one dredge station on the East Pacific Rise near 13°N were formed by secondary oxidation in a low temperature, oxygenated environment. In comparison with the elemental (Zn, Cd, Pb, Fe, Co, Cu) average content of hydrothermal sulfide samples from the East Pacific Rise near 13°N, the Zn, Cd, and Pb contents of the Fe-oxyhydroxides are lower, and their Fe, Co, and Cu contents are higher. | ZENG ZhiGang WANG XiaoYuan ZHANG GuoLiang YIN XueBo CHEN DaiGeng WANG XiaoMei | 2008 | Science China Earth Sciences2008，51，2： | 12 |
| 8 | Stress-mediated p38 activation promotes somatic cell reprogramming显示文摘环境调停压力的改编在生活的进化起必要作用。细胞的改编机制通常包含染色质结构,抄写, mRNA 稳定性和翻译的规定,它最后在基因表示导致有效变化。全球 epigenetic 变化也涉及体的细胞的 reprogramming 进导致的 pluripotent 由定义因素的茎(iPS ) 细胞。这里,我们报导象 hyperosmosis 那样的那个环境压力不仅便于四调停因素的 reprogramming,而且提高二或一导致因素的 iPS 房间代。导致 Hyperosmosis 的 p38 激活在这个过程起一个关键作用。组成的活跃 p38 模仿 hyperosmosis 的积极效果,当主导的否定 p38 和 p38 禁止者堵住 hyperosmosis 的效果时。进一步的学习显示调停压力的 p38 激活可以由减少全球 DNA methylation 水平并且提高 pluripotency 基因的表示支持 reprogramming。我们的结果表明象 hyperosmosis 一样的简单环境应力怎么帮助经由细胞内部的发信号和 epigenetic 调整改变房间的命运。 | Xinxiu Xu Quan Wang Yuan Long Ru Zhang Xiaoyuan Wei Mingzhe Xing Haifeng Gu Xin Xie | 2013 | Cell Research2013，23，1： | 12 |
| 9 | Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles显示文摘磁性的 nanoparticles 对很多个癌症房间被用作药交货车辆。大多数这些 theranostic 明确的表达使用了为两磁性的回声成像(MRI ) 和癌症治疗作为 nano 搬运人明确的表达与 chemotherapeutics 装载的稳固的氧化铁 nanoparticles (SIONP ) 。在这研究,我们使用了 dopamine-plus-human 浆液白朊(HSA ) 方法在 nano 搬运人的空多孔的结构以内修改空氧化铁 nanoparticles (HIONP ) 和 encapsuated doxorubicin (纪录影片) 。新交货系统能用一样的涂层策略比一样的核心尺寸的稳固的氧化铁 nanoparticles 装载更多的药。HIONPs 纪录影片明确的表达也有 pH 依赖的药版本行为。与免费纪录影片相比, HIONPs 纪录影片有效地是更多由 multidrug 的 uptaken 抵抗 OVCAR8-ADR 房间并且因而在杀死药的更多的有势力抵抗癌症房间。MRI 幽灵和房间研究也证明 HIONPs 纪录影片能减少当充当药交货车辆时, T 2 MRI 信号紧张和罐头被用作一个 MRI 对比代理人。第一次, chemo 药运输的双申请和用 HIONPs 纪录影片明确的表达的先生成像对纪录影片敏感、纪录影片抵抗的癌症房间被完成。 | Ruijun Xing Ashwinkumar A. Bhirde Shouju Wang Xiaolian Sun Gang Liu Yanglong Hou Xiaoyuan Chen | 2013 | Nano Research2013，6，1： | 11 |
| 10 | Leader-following consensus protocols for formation control of multi-agent network显示文摘Two protocols are presented,which can make agents reach consensus while achieving and preserving the desired formation in fixed topology with and without communication timedelay for multi-agent network.First,the protocol without considering the communication time-delay is presented,and by using Lyapunov stability theory,the sufficient condition of stability for this multi-agent system is presented.Further,considering the communication time-delay,the effectiveness of the protocol based on Lyapunov-Krasovskii function is demonstrated.The main contribution of the proposed protocols is that,as well as the velocity consensus is considered,the formation control is concerned for multi-agent systems described as the second-order equations.Finally,numerical examples are presented to illustrate the effectiveness of the proposed protocols. | Xiaoyuan Luo Nani Han Xinping Guan | 2011 | Journal of Systems Engineering and Electronics2011，22，6： | 10 |
| 11 | Features of colorectal cancer in China stratified by anatomic sites:A hospital-based study conducted in university-affiliated hospitals from 2014 to 2018显示文摘Objective:The clinical and biological characteristics of colorectal cancer have been found to differ depending on the anatomic site of the cancer.However,for Chinese patients,there is limited information on the proportion of cases at each site and the related features.In this study,we explored the location,distribution and other features of colorectal cancers at each anatomic site in Chinese patients.Methods:We conducted a hospital-based study using hospitalization summary reports from 10 Peking University-affiliated hospitals from 2014 to 2018;the reports covered a total of 2,097,347 hospitalizations.Incident cases were chosen as the study population,and their epidemiological features were further analyzed.Results:A total of 20,739 colorectal cancer patients were identified.Rectum was the most common location(48.3%)of the cancer,whereas the proportions of patients with distal and proximal colon cancer were 24.5%and18.6%,respectively.Patients with rectal cancer were predominantly male and were the youngest for all anatomical sites(each P<0.001).The highest proportion of emergency admissions,the longest hospital stays and the highest hospitalization costs were found in patients with proximal colon cancer(each P<0.001).The proximal colon cancer subgroup included the highest proportions of patients with medical histories of cholecystectomy,cholecystolithiasis and/or gallbladder polyps and appendectomy(P=0.009,P<0.001 and P<0.001,respectively).The distal colon cancer subgroup included the highest proportions of patients with medical histories of diabetes and hypertension(P<0.001,respectively).Conclusions:The patterns of colorectal cancer observed in this study differ from those reported for Western patients and show a significantly higher proportion of patients with rectal cancer.Different epidemiological features were also found based on anatomic sites.Further studies based on tumor location should be conducted to facilitate more accurate screening and treatment. | Ruize Qu Yanpeng Ma Liyuan Tao Xiaoyuan Bao Xin Zhou Bingyan Wang Fei Li Siyi Lu Lin Tuo Siyan Zhan Zhipeng Zhang Wei Fu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 10 |
| 12 | On the designing principles and optimization approaches of bio-inspired self-organized network: a survey显示文摘A plethora of studies on self-organization has been carried out in broad areas including chemistry, biology, astronomy, medical science, telecommunications, etc., in both academia and industry. Following the studies on swarm intelligence observed in social species, the artificial self-organized systems are expected to exhibit some intelligent features (e.g., flexibility, robustness, decentralized control, self-evolution, etc.) that may have made social species so successful in the biosphere. In this paper, the application of swarm intelligence in communications networks will be studied, and we survey different aspects of bio-inspired mechanisms and examine various algorithms that have been proposed to improve the performance of artificial systems. Some fundamental self-organized networking (SON) mechanisms, designing principles and optimization approaches for artificial systems will then be investigated, followed by some well-known bio-inspired algorithms (e.g., cooperation, division of labor, distributed network synchronization, load balancing, etc.) as well as their applications to the maintenance/operation/optimization of artificial systems being analyzed. Besides, some new emerging technologies, such as the Self-X capabilities and cognitive machine-to-machine (M2M) optimization for the 3rd Generation Partnership Project (3GPP) Long Term Evolution (LTE)/LTE-Advanced systems, are also surveyed. Finally, the remaining challenges to be faced in designing the future heterogeneous systems will be discussed. | ZHANG ZhongShan HUANGFU Wei LONG KePing ZHANG Xu LIU XiaoYuan ZHONG Bin | 2013 | Science China(Information Sciences)2013，56，7： | 9 |
| 13 | Short-range ordering and its effects on mechanical properties of high-entropy alloys显示文摘In this letter,we briefly summarize experimental and theoretical findings of fo rmation and characterization of short-range orderings(SROs)as well as their effects on the defo rmation behavior of high-entropy alloys(HEAs).We show that existence of SROs is a common yet key structural feature of HEAs,and tuning the degree of SROs is an effective way for optimizing mechanical properties of HEAs.In additional,the challenges concerning about formation mechanism and characterization of SROs in HEAs are discussed,and future research activities in this regard are also proposed. | Yuan Wu Fei Zhang Xiaoyuan Yuan Hailong Huang Xiaocan Wen Yihan Wang Mengyuan Zhang Honghui Wu Xiongjun Liu Hui Wang Suihe Jiang Zhaoping Lu | 2021 | Journal of Materials Science & Technology2021，，3： | 8 |
| 14 | Color-tunable Gd-Zn-Cu-ln-S/ZnS quantum dots for dual modality magnetic resonance and fluorescence imaging显示文摘 | Weisheng Guo Weitao Yang Yu Wang Xiaolian Sun Zhongyun Liu Bingbo Zhang Jin Chang Xiaoyuan Chen | 2014 | Nano Research2014，7，11： | 8 |
| 15 | Deep Fractionation of Clinopyroxene in the East Pacific Rise 13°N:Evidence from High MgO MORB and Melt Inclusions显示文摘从东方太平洋的海中央山脉暗岩(MORB ) 升起(EPR ) 13 ° N 为专业和踪迹元素被分析,哪个表演一个连续演变趋势。积极姆戈·艾尔 2 O 3 和否定 MgO Sc 关系表明斜长石和橄榄石的 cotectic 结晶化,它与斜长石和橄榄石斑晶和 clinopyroxene 斑晶的缺席的存在存在。然而, clinopyroxene 的分别被 MgO 和 CaO 的积极关联证明。因此, MORB 样品被相信显示出“ clinopyroxene 悖论”。最高忍受镁的 MORB 样品 E13 3B (MgO =9.52%) 在不同压力与 COMAGMAT 为等压的结晶化被建模。观察 CaO/Al 2 O 3 比率能在压力 >4 ± 1 kbar 仅仅由部分结晶化从 E13 3B 被导出,它要求 clinopyroxene 结晶化并且不与加在岩浆房间的斜长石的橄榄石的 cotectic 结晶化一致(在压力 ∼1 kbar ) 。melt 包括的起始的作文,能代表潜在的父母岩浆,被为陷阱以后的结晶化(PEC ) 改正重建。模仿的结晶化起始融化包括也生产观察 CaO/Al 2 仅仅在 >4 ± 1 kbar, clinopyroxene 在参加结晶化的 O 3 比率。MORB 岩浆在更低的外壳中经历了 clinopyroxene 分别,这被建议,在并且在莫霍转变地区下面。MORB 岩浆在 >4 ± 1 kbar 从 clinopyroxene+plagioclase+olivine 结晶化经历了转变到主要在 <1 kbar 的 olivine+plagioclase 结晶化,它贡献“ clinopyroxene 悖论”的解释。 | ZHANG Guoliang ZENG Zhigang YIN Xuebo WANG Xiaoyuan CHEN Daigeng | 2009 | Acta Geologica Sinica(English Edition)2009，83，2： | 7 |
| 16 | Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population显示文摘Antipsychotic-induced weight gain(AIWG) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. We aimed to review the progress of pharmacogenetic studies on AIWG in the Chinese population to compare the results for Chinese with other ethnic populations, identify the limitations and problems of current studies, and provide future research directions in China. Both English and Chinese electronic databases were searched to identify eligible studies. We determined that [ 25 single-nucleotide polymorphisms in19 genes have been investigated in association with AIWG in Chinese patients over the past few decades. HTR2 C rs3813929 is the most frequently studied single-nucleotide polymorphism, and it seems to be the most strongly associated with AIWG in the Chinese population. However, many genes that have been reported to be associated with AIWG in other ethnic populations have not beenincluded in Chinese studies. To explain the pharmacogenetic reasons for AIWG in the Chinese population,genome-wide association studies and multiple-center, standard, unified, and large samples are needed. | Chao Luo Junyan Liu Xu Wang Xiaoyuan Mao Honghao Zhou Zhaoqian Liu | 2019 | Neuroscience Bulletin2019，35，3： | 7 |
| 17 | Core Metabolic Features and Hot Origin of Bathyarchaeota显示文摘The archaeal phylum Bathyarchaeota comprises highly diversified subgroups and is considered to be one of the most abundant microorganisms on earth. The metabolic features and evolution of this phylum still remain largely unknown. In this article, a comparative metabolic analysis of 15 newly reconstructed and 36 published metagenomic assembled genomes (MAGs) spanning 10 subgroups was performed, revealing the core metabolic features of Bathyarchaeota—namely, protein, lipid, and benzoate degradation;glycolysis;and the Wood–Ljungdahl (WL) pathway, indicating an acetyl-CoA-centralized metabolism within this phylum. Furthermore, a partial tricarboxylic acid (TCA) cycle, acetogenesis, and sulfur-related metabolic pathways were found in specific subgroups, suggesting versatile metabolic capabilities and ecological functions of different subgroups. Intriguingly, most of the MAGs from the Bathy-21 and -22 subgroups, which are placed at the phylogenetic root of all bathyarchaeotal lineages and likely represent the ancient Bathyarchaeota types, were found in hydrothermal environments and encoded reverse gyrase, suggesting a hyperthermophilic feature. This work reveals the core metabolic features of Bathyarchaeota, and indicates a hot origin of this archaeal phylum. | Xiaoyuan Feng Yinzhao Wang Rahul Zubin Fengping Wang | 2019 | Engineering2019，5，3： | 7 |
| 18 | Structure and properties of an ultra-high strength 7xxx aluminum alloy contained Sc and Zr显示文摘An ultra-high strength aluminum alloy was produced by casting and then extruded to rods.The effect of heat treatment on the microstructure and mechanical properties of the alloy was investigated.After single ageing(120℃,24 h),the tensile strength was 812.4 MPa and the elongation was 6.2%.After retrogression reaging(RRA),the tensile strength was 751.2 MPa and the elongation was 6.4%.The strengthening mechanism is considered as fine grain strengthening,substructure strengthening and dispersion strengthening by Al_3(Sc,Zr). | Xiaoyuan Dai Changqing Xia Xiaomin Peng Ke Ma | 2008 | Journal of University of Science and Technology Beijing2008，15，3： | 7 |
| 19 | Mineralogical and micromorphological characteristics of Si-Fe-Mn oxyhydroxides from the PACMANUS hydrothermal field, Eastern Manus Basin显示文摘The mineralogical and micromorphological characteristics of Si-Fe-Mn oxyhydroxides from the dacite-hosted PACMANUS hydrothermal field were analyzed.The samples are poorly crystallized Si-Fe-Mn oxyhydroxides with minor birnessite, todorokite, nontronite, goethite, and opal-A.There are some microtextures which are rather like fossil microbes such as the filamentous silica and the hollow pipes.Flakes of nontronite crystals are found either forming a honeycomb texture or distrib- uted on the surface of the hollow pipes.Nontronite is the product precipitated from low-temperature hydrothermal fluids, and microbes may play a role in its formation.Si-Fe-Mn oxyhydroxides have two kinds of nuclei: Si-Mn nuclei and Si nuclei, both enveloped by the similar Si-Fe outer layer, existing in the rod-shaped oxyhydroxide and spheroidal oxyhydroxide, respectively.In the Si-Mn nuclei, the concentration of SiO2 is between 39.32 wt% and 86.31 wt%, and MnO concentration is between 4.97 wt% and 27.01 wt%, but Fe2O3 concentration is very low (0.54 wt%-3.43 wt%).In the Si nucleus the concentration of SiO2 is 90.17 wt%, but concentration of MnO and Fe2O3 are low, with 0.06 wt% and 3.47 wt%, respectively.The formation of the Si-Mn nucleus is closely related to microbes, whereas the Si nucleus is of inorganic origin. | ZENG ZhiGang CHEN Shuai WANG XiaoYuan OUYANG HeGen YIN XueBo LI ZhaoXue | 2012 | Science China Earth Sciences2012，55，12： | 7 |
| 20 | Rare earth elements in hydrothermal fluids from Kueishantao,off northeastern Taiwan: Indicators of shallow-water,sub-seafloor hydrothermal processes显示文摘The rare earth element(REE)geochemistry of hydrothermal vent systems has been investigated intensively,but few studies have been carried out on marine shallow-water hydrothermal systems like that at Kueishantao.Here we present novel data sets of REE in hydrothermal fluids from Kueishantao,off northeastern Taiwan.The total REE(REE)concentrations of yellowish fluids are similar to those of whitish fluids,813–1212 ng/L,and are significantly higher than that of ambient seawater.The yellowish fluids have chondrite-normalized REE(REEN)distribution patterns with slight convex-downward curvatures at Eu;and the REE patterns of the whitish fluids are smooth at Eu,which is related to the lower temperature and more oxidizing conditions.The Kueishantao hydrothermal fluids are slightly enriched in light REE(La-Nd)relative to the heavy REE(Gd-Lu).The behaviors of REE in both yellowish and whitish fluids are affected by the short time of water-rock interaction.The REE distributions in the yellowish fluids are also affected by very low pH(2.81 and 2.29),boiling of the fluid and precipitation of native sulfur.In the whitish fluids,adsorption by small particles and formation of REE-chloride complexes has played a role in the distribution of REE. | WANG XiaoYuan ZENG ZhiGang CHEN Shuai YIN XueBo CHEN Chen-Tung Arthur | 2013 | Chinese Science Bulletin2013，58，32： | 7 |
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