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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | A GA paradigm for learning fuzzy rules 显示文摘 | Lim M H Rahardja S Gwee B H | 1996 | Fuzzy Sets and Systems1996，72，2： | 2 |
| 3 | Flowdfield around ogive/elliptic-tip cylinder at high angle of attack显示文摘 | LIM T T LUA K B | 1998 | AIAA Journal1998，36，10： | 1 |
| 4 | Transpalatal advancement pharyngoplasty outcomes compared with uvulopalatopharygoplasty显示文摘 | WOODSON B T ROBINSON S LIM H J | 2005 | Otolaryngol Head NeckSurg2005，133，： | 1 |
| 5 | A GA paradigm for learning fuzzy rules显示文摘 | Lim M N Rahardjm S Gwee B H | 1996 | Fuzzy Systems1996，82，2： | 1 |
| 6 | Deconjugation of bile salts by Lactobacillus acidophilus isolates显示文摘 | AHN Y T KIM G B LIM K S | | 0，，： | 1 |
| 7 | Forward kinematics solution of stewartplatform using neural networks 显示文摘 | YEE C S LIM K B | 1997 | Neurocomputing1997，16，3： | 1 |
| 8 | Environmentally friendly preparation of pec- fins from agricultural byproducts and their strnctural/rheological char- acterization 显示文摘 | Min B Lim J Ko S | 2011 | Bioresource Technology2011，102，4： | 1 |
| 9 | Gene induction by glycyrol to apoptosis through endonuclease G in tumor cells and prediction of oncogene function by microarray analysis显示文摘 | Lee S 0h H M Lim W B | 2008 | Anticancer Drugs2008，19，5： | 1 |
| 10 | Advanced concentration gradient cathode material with two-slope for high-energy and safe lithium batteries显示文摘 | Lim B B Yoon S J Park K J | 2015 | Advanced Functional Materials2015，25，29： | 1 |
| 11 | Physiologicraces of Helminthosporium maydis and disease resistance显示文摘 | Hooker A L Smith B R Lim S F et d | 1970 | Plant Disease Reporter1970，54，： | 1 |
| 12 | Study on oxygen/nitrogen gas mixtures for the surface insu- lation performance in gas insulated switchgear显示文摘 | Lim S B | 2015 | IEEE Transactions on Dielectrics and Electrical Insulation2015，22，3： | 1 |
| 13 | Gradual Postharvest Cooling Reduces Blackening Disorder in ‘ Niitaka ’ Pear( Pyrus pyridolia ) Fruits显示文摘 | Lim B S Kim J K | 2005 | Kor Soc Hort Sci2005，46，5： | 1 |
| 14 | Microstructure evolution and hardening behavior of 2024 aluminum alloy processed by severe plastic deformation 显示文摘 | Kang S B Lim C Y Kim H W | 2002 | Materials Science Forum2002，，2： | 1 |
| 15 | A continuum model for size-dependent deformation of elastic films of nanoscale thickness显示文摘 | He L H Lim C W Wu B S | 2004 | International Journal of Solids and Structures2004，41，： | 1 |
| 16 | Small-signal analysis and control design of asymmetrical half-bridge DC-DC converters 显示文摘 | CHOI B LIM W BANG S | 2006 | IEEE Transaction on Industrial Electronics2006，52，： | 1 |
| 17 | A modified ultrasonic linear motor显示文摘 | Zhai B Lim S P Lee K H | | 0，，03： | 1 |
| 18 | A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China显示文摘 | You-lin Qiao John W Sellors Paul S Eder Yan-ping Bao Jeanette M Lim Fang-hui Zhao Bernhard Weigl Wen-hua Zhang Roger B Peck Ling Li Feng Chen Qing-jing Pan Attila T Lorincz | 2008 | Lancet Oncology2008，，10： | 1 |
| 19 | Removal of heavy metal ions from water by crosslinked carboxymethyl corn starch显示文摘 | KIM B S LIM S T | 1991 | Carbohydrate Polymers1991，39，： | 1 |
| 20 | Formation of microparticulate protein powders using a supercritical fluid antisolvent 显示文摘 | YEO S D LIM G B DEBENEDETTI P G | 1993 | Bioteehnology and Bioengineering1993，41，3： | 1 |
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