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| 1 | Comparison of the short-term and long-term outcomes of laparoscopic hysterectomies and of abdominal hysterectomies: a case study of 4,895 patients in the Guangxi Zhuang Autonomous Region, China显示文摘Background: To evaluate the short-term and long-term outcomes after laparoscopic hysterectomy(LH) compared with abdominal hysterectomy(AH) in case of benign gynecological disease. Methods: A multi-center cohort retrospective comparative study of population among 4,895 hysterectomies(3,539 LH vs.1,356 AH) between 2007 and 2013 was involved. Operative time(OT), estimated blood loss(EBL), intra-operative and post-operative complications, passing flatus; days with indwelling catheter, questionnaires covering pelvic floor functions and sexual functions were assessed.Results: The EBL(174.1±157.4 vs. 263.1±183.2 cc, LH and AH groups, respectively), passing flatus(38.7±14.1 vs. 48.1±13.2 hours), days with indwelling catheter(1.5±0.6 vs. 2.2±0.8 days), use of analgesics(6.5% vs. 73.1%), intra-operative complication rate(2.4% vs. 4.1%), post-operative complication rate(2.3% vs. 5.7%), post-operative constipation(12.1% vs. 24.6%), mild and serious stress urinary incontinence(SUI) post-operative(P<0.001; P=0.014), and proportion of Female Sexual Functioning Index(FSFI) total score <26.55 post-operative(P<0.001) of the LH group were significantly less than those of AH group. There wereno significant differences in OT(106.5±34.5 vs. 106.2±40.3 min) between the two groups.Conclusions: LH is a safe and efficient operation for improving patients' long-term quality of life(Qo L), and LH is a cost-effectiveness procedure for treating benign gynecological disease. LH is superior to AH due to reduced EBL, reduced post-operative pain and earlier passing flatus. | Hongying He Zhijun Yang Dingyuan Zeng Jiangtao Fan Xiaoxia Hu Yuan Ye Hua Bai YanmingJiang Zhong Lin Zhiying Lei Xinlin Li Lian Li Jinghua Gan Ying Lan Xiongzhi Tang Danxia Wang Junsong Jiang Xiaoyan Wu Meiying Li Xiaoqing Ren Xiaomin Yang Mei Liu Qinmei Wang Fuyan jiang Li Li | 2016 | Chinese Journal of Cancer Research2016，28，2： | 6 |
| 2 | Survey on depth and RGB image-based 3D hand shape and pose estimation显示文摘The field of vision-based human hand three-dimensional(3D)shape and pose estimation has attracted significant attention recently owing to its key role in various applications,such as natural human computer interactions.With the availability of large-scale annotated hand datasets and the rapid developments of deep neural networks(DNNs),numerous DNN-based data-driven methods have been proposed for accurate and rapid hand shape and pose estimation.Nonetheless,the existence of complicated hand articulation,depth and scale ambiguities,occlusions,and finger similarity remain challenging.In this study,we present a comprehensive survey of state-of-the-art 3D hand shape and pose estimation approaches using RGB-D cameras.Related RGB-D cameras,hand datasets,and a performance analysis are also discussed to provide a holistic view of recent achievements.We also discuss the research potential of this rapidly growing field. | Lin HUANG Boshen ZHANG Zhilin GUO Yang XIAO Zhiguo CAO Junsong YUAN | 2021 | Virtual Reality & Intelligent Hardware2021，3，3： | 1 |
| 3 | Baicalin inhibits hypoxia-induced pulmonary artery smooth mus- cle cell proliferation via the AKT/HIF-1 ot/p27-associat- ed pathway 显示文摘 | Zhang Lin Pu Zhichen Wang Junsong | 2014 | Int J Mol Sci2014，15，5： | 1 |
| 4 | Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19显示文摘COVID-19 patients exhibit differential disease severity after SARS-CoV-2 infection.It is currently unknown as to the correlation between the magnitude of neutralizing antibody(NAb)responses and the disease severity in COVID-19 patients.In a cohort of 59 recovered patients with disease severity including severe,moderate,mild,and asymptomatic,we observed the positive correlation between serum neutralizing capacity and disease severity,in particular,the highest NAb capacity in sera from the patients with severe disease,while a lack of ability of asymptomatic patients to mount competent NAbs.Furthermore,the compositions of NAb subtypes were also different between recovered patients with severe symptoms and with mild-tomoderate symptoms.These results reveal the tremendous heterogeneity of SARS-CoV-2-specific NAb responses and their correlations to disease severity,highlighting the needs of future vaccination in COVID-19 patients recovered from asymptomatic or mild illness. | Xiangyu Chen Zhiwei Pan Shuai Yue Fei Yu Junsong Zhang Yang Yang Ren Li Bingfeng Liu Xiaofan Yang Leiqiong Gao Zhirong Li Yao Lin Qizhao Huang Lifan Xu Jianfang Tang Li Hu Jing Zhao Pinghuang Liu Guozhong Zhang Yaokai Chen Kai Deng Lilin Ye | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 5 | A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global pandemic of novel coronavirus disease(COVID-19).The neutralizing monoclonal antibodies(mAbs)targeting the receptor-binding domain(RBD)of SARS-CoV-2 are among the most promising strategies to prevent and treat COVID-19.However,SARS-CoV-2 variants of concern(VOCs)profoundly reduced the efficacies of most of mAbs and vaccines approved for clinical use.Herein,we demonstrated mAb 35B5 efficiently neutralizes both wild-type(WT)SARS-CoV-2 and VOCs. | Xiaofei Wang Ao Hu Xiangyu Chen Yixin Zhang Fei Yu Shuai Yue Arong Li Junsong Zhang Zhiwei Pan Yang Yang Yao Lin Leiqiong Gao Jing Zhou Jing Zhao Fang Li Yaling Shi Feng Huang Xiaofan Yang Yi Peng Luoyang Tu Huan Zhang Huanying Zheng Jun He Hui Zhang Lifan Xu Qizhao Huang Yongqun Zhu Kai Deng Lilin Ye | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 1 |
| 6 | Amphibian-derived peptide homodimer OA-GL17d promotes skin wound regeneration through the miR-663a/TGF-β1/Smad axis显示文摘Background:Amphibian-derived peptides exhibit considerable potential in the discovery and development of new therapeutic interventions for clinically challenging chronic skin wounds.MicroRNAs(miRNAs)are also considered promising targets for the development of effective therapies against skin wounds.However,further research in this field is anticipated.This study aims to identify and provide a new peptide drug candidate,as well as to explore the underlying miRNA mechanisms and possible miRNA drug target for skin wound healing.Methods:A combination of Edman degradation,mass spectrometry and cDNA cloning were adopted to determine the amino acid sequence of a peptide thatwas fractionated from the secretion of Odorrana andersonii frog skin using gel-filtration and reversed-phase high-performance liquid chromatography.The toxicity of the peptide was evaluated by Calcein-AM/propidium iodide(PI)double staining against human keratinocytes(HaCaT cells),hemolytic activity against mice blood cells and acute toxicity against mice.The stability of the peptide in plasma was also evaluated.The prohealing potency of the peptide was determined by MTS,scratch healing and a Transwell experiment against HaCaT cells,full-thickness injury wounds and scald wounds in the dorsal skin of mice.miRNA transcriptome sequencing analysis,enzyme-linked immunosorbent assay,real-time polymerase chain reaction and western blotting were performed to explore the molecular mechanisms.Results:A novel peptide homodimer(named OA-GL17d)that contains a disulfide bond between the 16th cysteine residue of the peptide monomer and the sequence‘GLFKWHPRCGEEQSMWT’was identified.Analysis showed that OA-GL17d exhibited no hemolytic activity or acute toxicity,but effectively promoted keratinocyte proliferation and migration and strongly stimulated the repair of full-thickness injury wounds and scald wounds in the dorsal skin of mice.Mechanistically,OA-GL17d decreased the level of miR-663a to increase the level of transforming growth factor-β1(TGF-β1)and activate the subsequent TGF-β1/Smad signaling pathway,thereby resulting in accelerated skin wound re-epithelialization and granular tissue formation.Conclusions:Our results suggest that OA-GL17d is a new peptide drug candidate for skin wound repair.This study emphasizes the importance of exogenous peptides as molecular probes for exploring competing endogenous RNA mechanisms and indicates that miR-663a may be an effective target for promoting skin repair. | Yue Zhang Ying Wang Lin Zeng Yixiang Liu Huiling Sun Shanshan Li Siyu Wang Longjun Shu Naixin Liu Saige Yin Junsong Wang Dan Ni Yutong Wu Ying Yang Li He Buliang Meng Xinwang Yang | 2022 | Burns & Trauma2022，10，1： | 0 |
| 7 | A novel water-soluble anionic conjugated copolymer containing poly(p-phenylene vinylene) segments:Copolymer synthesis and multilayer construction by assembling poly(diallyl dimethyl ammonium chloride)显示文摘This paper reports the synthesis of a water soluble conjugated polymer poly(p-phenylene vinyleneco-sodium methacrylate) (ws-P(PV-co-SMA)) and the multilayer of the derived copolymer assembling poly(diallyl dimethyl ammanium chloride) (PDDA). The self-assembling process of the multilayer was monitored by UV-vis absorption spectroscopy, and the data indicated a linear increase in film thick- ness with a number of ws-P(PV-co-SMA)/PDDA bilayers. The alternative deposition of ws-P (PV-co-SMA) and PDDA allowed the insertion of a non-conjugated layer between the conjugated layers, thus the migration of the photogenerated polarons was effectively confined in the isolated ws-P (PV-co-SMA) chains. Consequently, the photoluminescence quantum yield reached 0.68, 30 times higher than that of pure poly(p-phenylen vinylene). The distinct electronic interactions between conjugated segments were confirmed by comparative analyses of the excitation spectra and time-resolved photoluminescence spectra of ws-P(PV-co-SMA) solid film and the assembled multilayers. The confinement effect of the PDDA layer on the photogenerated carriers was verified by the surface photovoltage spectroscopic measurement on both ws-P(PV-co-SMA) solid film and self-assembled multilayers. | ZHANG Bao LIN Hang TANG Jun LIU JunSong | 2009 | Chinese Science Bulletin2009，54，19： | 0 |
| 8 | Evaporation of Intermediate-mass Fragments from Hot-nuclei Produced by 25MeV/u ^(40)Ar Bombarding ^(159)Tb Target显示文摘Evaporation of Intermediate-mass Fragments from Hot-nuclei Produced by 25MeV/u^(40)Ar Bombarding^(159)Tb Target￥JiangDongxing;... | Jiang Dongxing Qian Xing Qian Tao Hua Hui Lin Junsong Wu Enjiu Zheng Jiwen Jing Genming Yin Shuzhi Tan Jilin Jing Weiyang Song Mingtao Li Zuyu and He Zhiyong | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
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