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| 1 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 2 | NATURAL FREQUENCY OF COMPONENT UNDER INFLUENCE OF WELDING RESIDUAL STRESS显示文摘According to the distribution feature of welding residual stress on plate with welding seam along axis,a mathematical model of the welding residual stress is established.A formula of natural frequency of four boundary simply-supported quadrate thin plate with welding residual stress is developed.Some conclusions have been obtained.They are:(1)if there is welding residual stress,all natural frequencies of component are in increase,(2)change of high rank natural frequency under the influence of residual stress is larger than that of low rank natural frequency,and the higher the rank number is the larger the absolute amount of change of natural frequency is. | Gao Yongyi Lin Lichuan | 1996 | Transactions of Nonferrous Metals Society of China1996，6，1： | 2 |
| 3 | Experimental modal analysis on damage of skeleton in brake of airplane显示文摘The relation between damage and modal parameters of skeleton has been discussed and analysed. Some significant results for detecting damage have been obtained by using experimental data of ω di and ζ i . Then, the modal experiments of four type of skeleton have been performed, the modal bifurcation phenomenon is discovered. It follows that this method for studying skeleton damage is a very promising method through theoretical and experimental analysis. | Xie Zuoji(谢祚济) Lin Lichuan(林丽川) | 1999 | 中国有色金属学会会刊:英文版1999，9，3： | 0 |
| 4 | Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma in vitro and in vivo显示文摘Nasopharyngeal carcinoma(NPC)is a malignant tumor that mainly occurs in East and Southeast Asia.Although patients benefit from the main NPC treatments(e.g.,radiotherapy and concurrent chemotherapy),persistent and recurrent diseases still occur in some NPC patients.Therefore,investigating the pathogenesis of NPC is of great clinical significance.In the present study,replication factor c subunit 4(RFC4)is a key potential target involved in NPC progression via bioinformatics analysis.Furthermore,the expression and mechanism of RFC4 in NPC were investigated in vitro and in vivo.Our results revealed that RFC4 was more elevated in NPC tumor tissues than in normal tissues.RFC4 knockdown induced G2/M cell cycle arrest and inhibited NPC cell proliferation in vitro and in vivo.Interestingly,HOXA10 was confirmed as a downstream target of RFC4,and the overexpression of HOXA10 attenuated the silencing of RFC4-induced cell proliferation,colony formation inhibition,and cell cycle arrest.For the first time,this study reveals that RFC4 is required for NPC cell proliferation and may play a pivotal role in NPC tumorigenesis. | Shuzhen Guan Lin Feng Jinrui Wei Guizhen Wang Lichuan Wu | 2023 | Frontiers of Medicine2023，17，1： | 0 |
| 5 | The PilZ domain of MrkH represents a nove )NA binding motif显示文摘 | Feng Wang Qing He Kaixuan Su Fei Gao Yan Huang Zong Lin Deyu Zhu Lichuan Gu | 2016 | Protein & Cell2016，7，10： | 0 |
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