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| 1 | Computed tomography-identified phenotypes of small airway obstructions in chronic obstructive pulmonary disease显示文摘Chronic obstructive pulmonary disease(COPD)is a heterogeneous disease characteristic of small airway inflammation,obstruction,and emphysema.It is well known that spirometry alone cannot differentiate each separate component.Computed tomography(CT)is widely used to determine the extent of emphysema and small airway involvement in COPD.Compared with the pulmonary function test,small airway CT phenotypes can accurately reflect disease severity in patients with COPD,which is conducive to improving the prognosis of this disease.CT measurement of central airway morphology has been applied in clinical,epidemiologic,and genetic investigations as an inference of the presence and severity of small airway disease.This review will focus on presenting the current knowledge and methodologies in chest CT that aid in identifying discrete COPD phenotypes. | Tao Li Hao-Peng Zhou Zhi-Jun Zhou Li-Quan Guo Linfu Zhou | 2021 | Chinese Medical Journal2021，，17： | 8 |
| 2 | Association between socioeconomic status and chronic obstructive pulmonary disease in Jiangsu province, China: a population-based study显示文摘Background:Chronic obstructive pulmonary disease(COPD)is a common public health problem worldwide.Recent studies have reported that socioeconomic status(SES)is related to the incidence of COPD.This study aimed to investigate the association between SES and COPD among adults in Jiangsu province,China,and to determine the possible direct and indirect effects of SES on the morbidity of COPD.Methods:A cross-sectional study was conducted among adults aged 40 years and above between May and December of 2015 in Jiangsu province,China.Participants were selected using a multistage sampling approach.COPD,the outcome variable,was diagnosed by physicians based on spirometry,respiratory symptoms,and risk factors.Education,occupation,and monthly family average income(FAI)were used to separately indicate SES as the explanatory variable.Mixed-effects logistic regression models were introduced to calculate odds ratios(ORs)and 95%confidence intervals(CIs)for examining the SES-COPD relationship.A pathway analysis was conducted to further explore the pulmonary function impairment of patients with different SES.Results:The mean age of the 2421 participants was 56.63±9.62 years.The prevalence of COPD was 11.8%(95%CI:10.5%–13.1%)among the overall sample population.After adjustment for age,gender,residence,outdoor and indoor air pollution,body weight status,cigarette smoking,and potential study area-level clustering effects,educational attainment was negatively associated with COPD prevalence in men;white collars were at lower risk(OR:0.60,95%CI:0.43–0.83)of experiencing COPD than blue collars;compared with those within the lower FAI subgroup,participants in the upper(OR:0.68,95%CI:0.49–0.97)tertiles were less likely to experience COPD.Such negative associations between all these three SES indicators and COPD were significant among men only.Education,FAI,and occupation had direct or indirect effects on pulmonary function including post-bronchodilator forced expiratory volume in 1 s/forced vital capacity(FEV1/FVC),FEV1,FVC,and FEV1 percentage of predicted.Education,FAI,and occupation had indirect effects on pulmonary function indices of all participants mainly through smoking status,indoor air pollution,and outdoor air pollution.We also found that occupation could affect post-bronchodilator FEV1/FVC through body mass index.Conclusions:Education,occupation,and FAI had an adverse relationship with COPD prevalence in Jiangsu province,China.SES has both direct and indirect associations with pulmonary function impairment.SES is of great significance for COPD morbidity.It is important that population-based COPD prevention strategies should be tailored for people with different SES. | Dan-Dan Zhang Jian-Nan Liu Qing Ye Zi Chen Ling Wu Xue-Qing Peng Gan Lu Jin-Yi Zhou Ran Tao Zhen Ding Fei Xu Linfu Zhou | 2021 | Chinese Medical Journal2021，，13： | 5 |
| 3 | Sialic acid-binding immunoglobulin-like lectin 9 as a potential therapeutic target for chronic obstructive pulmonary disease显示文摘Chronic obstructive pulmonary disease(COPD)has become the third-leading cause of death worldwide,which is a severe economic burden to the healthcare system.Chronic bronchitis is the most common condition that contributes to COPD,both locally and systemically.Neutrophilic inflammation predominates in the COPD airway wall and lumen.Logically,repression of neutrophilia is an essential fashion to COPD treatment.However,currently available anti-neutrophilic therapies provide little benefit in COPD patients and may have serious side effects.Thus,there is an urgent need to explore an effective and safe anti-neutrophilic approach that might delay progression of the disease.Sialic acid-binding immunoglobulin-like lectin(Siglec)-9 is a member of the Siglec cell surface immunoglobulin family.It is noteworthy that Siglec-9 is highly expressed on human neutrophils and monocytes.Ligation of Siglec-9 by chemical compounds or synthetic ligands induced apoptosis and autophagic-like cell death in human neutrophils.Furthermore,administration of antibody to Siglec-E,mouse functional ortholog of Siglec-9,restrained recruitment and activation of neutrophils in mouse models of airway inflammation in vivo.Given the critical role that neutrophils play in chronic bronchitis and emphysema,targeting Siglec-9 could be beneficial for the treatment of COPD,asthma,fibrosis,and related chronic inflammatory lung diseases. | Zi Chen Shuang-Lan Xu Lin-Yang Ge Jin Zhu Tao Zheng Zhou Zhu Linfu Zhou | 2021 | Chinese Medical Journal2021，，7： | 5 |
| 4 | Preparation of Starch Succinate WITH INTERMEDIATE DS BY AQUEOUS SLURRY REACTION显示文摘The succinylation of cornstarch by slurry reaction has been studied using sodium hydroxide as catalyst. Several reaction parameters afJecting the succinylation were investigated including the concentration of starch in water, the ratio of succinic anhydride to starch, the reaction time and the reaction temperature. The favorable conditions for an intermediate degree of substitution (DS) and reasonably high reaction efficiency (RE) are pH 8.5~9.0, 50% starch by weight to water, succinic anhydride to starch I/I (w/w), reaction time 4h, reaction temperature 30 ℃Under these conditions, the DS of 0.45 and RE of 28% were achieved. The addition of an adequate amount of crosslinking agent imparted starch succinate water absorbency. | ZHU Changying WANG Bin ZHAO Fukai CAO Yurong WANG Linfu XU Jiayi Department of Chemistry, NanKai University, Tianjin, 300071, China | 2001 | Chinese Journal of Reactive Polymers2001，10，2： | 5 |
| 5 | Stem cell therapy for chronic obstructive pulmonary disease显示文摘Chronic obstructive pulmonary disease(COPD),characterized by persistent and not fully reversible airflow restrictions,is currently one of the most widespread chronic lung diseases in the world.The most common symptoms of COPD are cough,expectoration,and exertional dyspnea.Although various strategies have been developed during the last few decades,current medical treatment for COPD only focuses on the relief of symptoms,and the reversal of lung function deterioration and improvement in patient^quality of life are very limited.Consequently,development of novel effective therapeutic strategies for COPD is urgently needed.Stem cells were known to differentiate into a variety of cell types and used to regenerate lung parenchyma and airway structures.Stem cell therapy is a promising therapeutic strategy that has the potential to restore the lung function and improve the quality of life in patients with COPD.This review summarizes the current state of knowledge regarding the clinical research on the treatment of COPD with mesenchymal stem cells(MSCs)and aims to update the understanding of the role of MSCs in COPD treatment,which may be helpful for developing effective therapeutic strategies in clinical settings. | Yun-Tian Chen Kang Miao Linfu Zhou Wei-Ning Xiong | 2021 | Chinese Medical Journal2021，，13： | 4 |
| 6 | Virtual Field Geologic Trip System显示文摘Virtual Field Geologic Trip System (VFGTS) constructed by the technique of visualization can efficiently present geologic field information and widely used in the field of geologic education. This paper introduces the developing thinking of VFGTS and discusses the main implement processes. Building VFGTS mainly includes systemically gathering of field geological data, the building of virtual geological world, and displaying of virtual geologic world and human-computer interaction. | Jian Wang, Linfu Xue, Xiaojun ZhouCollege of Earth Sciences, Jilin University, Changchun, 130061 China | 2003 | Global Geology2003，8，2： | 3 |
| 7 | T cell responses in respiratory viral infections and chronic obstructive pulmonary disease显示文摘Respiratory viruses are major human pathogens that cause approximately 200 million pneumonia cases annually and induce various comorbidities with chronic obstructive pulmonary disease(COPD),resulting in significant health concerns and economic burdens.Clinical manifestations in respiratory viral infections and inflammations vary from asymptomatic,mild,to severe,depending on host immune cell responses to pathogens and interactions with airway epithelia.We critically review the activation,effector,and regulation of T cells in respiratory virus infections and chronic inflammations associated with COPD.Crosstalk among T cells,innate immune cells,and airway epithelial cells is discussed as essential parts of pathogenesis and protection in viral infections and COPD.We emphasize the specificity of peptide antigens and the functional heterogeneity of conventional CD4^(+) and CD8^(+) T cells to shed some light on potential cellular and molecular candidates for the future development of therapeutics and intervention against respiratory viral infections and inflammations. | Shouxiong Huang Quan He Linfu Zhou | 2021 | Chinese Medical Journal2021，，13： | 2 |
| 8 | Tectonic evolution of the Changling fault basin and its relationship to oil and gas accumulation显示文摘The Changling fault depression passed through three stages of evolution: a period of faulting, a period of subsidence, and an inversion period. The fault lifted the whole area and the formation was eroded during the late Yingcheng formation, the late Nenjiang formation, and the late Mingshui formation. The denudation quantity of eight wells located in the study area is estimated by the interval transit time method and by the formation trend extension method using seismic and drilling data. Inversion back stripping technology with de-compaction correction was used to restore the original sedimentary thickness step by step and to recover the burial history at a single well. Two profiles were selected for the recovery and study of the tectonic evolution. The study confirmed that the primary major gas bearing structure formed due to thermal shrinkage lifting during the late Yingcheng formation. Successive development in a pattern during the late Mingshui formation led to the formation of the primary gas pool. Vertical differential uplift during the late Nenjiang formation formed the Fulongquan structure during the late Paleogene. At this same time a secondary gas pool formed. A large scale reverse developed late in the Mingshui formation that provided the impetus for formation of a secondary gas pool. It is thought that the migration and accumulation of oil and gas was controlled by lithologic character, fracture, and structure. The local uplift in the vicinity of the hydrocarbon recession is most conducive to the collection of hydrocarbon gas. | Wang Jianqiang Yang Guang Xue Linfu Zhang Jianwei Bai Ye Li Wenbo | 2011 | Mining Science and Technology2011，21，3： | 2 |
| 9 | Design and implementation of web fast sharing platform of massive geological map显示文摘It is still a laborious work to consult massive multidisciplinary geological maps which are scattered in different geological departments,and hard to give full play to the potential application value of geological map. Along with the network,the development of communication and computer technology,especially with the Web2.0 technology arisen,provides opportunities to the web for sharing of geological maps. Web fast sharing platform of massive geological maps( WSPGM) is based on the Flex technology development,using B/S architecture,with map navigation,search,display,security and other functions of the software system. Through the map pretreatment and asynchronous communication the system can display any size of geological map,and through the range limits,rights management,sharing system and watermark logo to take effective security on geological map. On the basis of this system,with the Jilin University web sharing system of geological map,the system can greatly improve the efficiency of using geological map. for research. | YAN Yan XUE Linfu ZHANG Wei LI Wenqing | 2012 | Global Geology2012，15，2： | 2 |
| 10 | Sartrolides A-G and bissartrolide, new cembranolides from the South China Sea soft coral Sarcophyton trocheliophorum Marenzeller 显示文摘 | LIANG Linfu LAN Lefu GUO Yuewei | 2013 | Tetrahedron2013，69，35： | 1 |
| 11 | A policy of conflict negotiation based on fuzzy matter element particle swarm optimization in distributed collaborative creative design显示文摘 | YIN Yanchao SUN Linfu GUO Cheng | 2008 | Computer-Aided Design2008，40，10： | 1 |
| 12 | Pregaraction of starch succinates by reactive extrusion显示文摘 | Wang Linfu Shogren R L Willett J L | 1997 | Starch1997，49，： | 1 |
| 13 | Geochronological and geochemical constraints on the granitic gneiss in the Huozhou Complex: implications for the tectonic evolution of the Trans-North China Orogen显示文摘The Trans-North China Orogen is a major Neoarchean Paleoproterozoic collisional orogenic belt above the North China Craton, formed due to prolonged and complex processes. Even though many NeoarcheanPaleoproterozoic magmatic and metamorphic activities have been reported, due to the Huozhou Complex’s small outcropping range, little attention has been paid to the origin of various igneous rocks of the Huozhou Complex in the center of the Trans-North China Orogen. The Huozhou Complex, located south of the Luè liang, Wutai, and Hengshan complexes, is an important window into the Early Precambrian structure and evolution of the North China Craton. Its magma and metamorphism are crucial to understanding the development of the structural evolution of the Trans-North China Orogen. The Huozhou metamorphic complex area exposes a range of Precambrian metamorphic rocks, among which the most extensively dispersed is felsic biotite plagioclase gneiss. In this study comprehensive geological field survey, micropetrology,chronology, geochemistry, and Hf isotope analysis were carried out for the Qinggangping and Anziping gneiss in the north of the Huozhou Complex. The results show that the magmatic zircon age of the Qinggangping gneiss is2196 ± 14 Ma, and its protolith is I-type granite, formed by partial melting of igneous rocks in the absence of weathering. Its source is mainly the juvenile crust from depleted mantle dating 2431–2719 Ma, with a small amount of mantle-derived material. The Anziping gneiss has a metamorphic zircon age of 1931 ± 13 Ma with an S-type granite protolith belonging to peraluminous granite.The Anziping gneiss is formed by recycling pre-existing crustal components at 2613–2848 Ma. A minor quantity of mantle-derived magma is also introduced to the crust simultaneously. The samples of Qinggangping gneiss and Anziping gneiss show the characteristics of obvious negative Nb, Ti, and P elements in the spider diagram of primitive mantle standardization. This implies that the rocks have the characteristics of magmatic rocks in an island arc or subduction environment, which could have formed in the tectonic environment of the continental margin arc. | Chong Peng Haiyan Liu Ruiying Zhang Cremilda Samuel Jofrisse Linfu Xue Baozhi Pan | 2023 | Acta Geochimica2023，42，1： | 1 |
| 14 | Inhibitory effects of astragaloside 1V on ovalbumin-induced chronic experi- mental asthma 显示文摘 | DU Qiang CHEN Zhen ZHOU Linfu | 2008 | Can J Physiol Pharmacol2008，86，7： | 1 |
| 15 | Immunomod-ulatory function of orally administered thymosinα1显示文摘 | Chen Xiangming Jiang Hanliang Zhou Linfu | | 0，，9： | 1 |
| 16 | Interpretation of remote sensing of geological structures and prediction of gold mineralization in Mohe area and its adjacent region显示文摘The authors took the ETM+ multi-spectra data as the data information and correlation coefficient for each band and carried out their information volume statistics.According to certain criteria,the authors also determined the optimum band-combined image.The image clarity is improved by various enhancements and fusions method.Based on remote sensing geological interpretation in detail,the relationship between remote sensing geological characters and gold mine were analyzed systemically.Using all kinds of remote sensing structure information,combining other research data,the authors determined mainly ore-controlling ore structure.Several prospective areas of gold ores were determined and furthermore significant finding mine target areas was confirmed. | Ruiqing QIE Linfu XUE Shixiang LIU Yunliang YU | 2007 | Global Geology2007，10，1： | 1 |
| 17 | Spatial data mining system for ore-forming prediction显示文摘The authors designed the spatial data mining system for ore-forming prediction based on the theory and methods of data mining as well as the technique of spatial database,in combination with the characteristics of geological information data.The system consists of data management,data mining and knowledge discovery,knowledge representation.It can syncretize multi-source geosciences data effectively,such as geology,geochemistry,geophysics,RS.The system digitized geological information data as data layer files which consist of the two numerical values,to store these files in the system database.According to the combination of the characters of geological information,metallogenic prognosis was realized,as an example from some area in Heilongjiang Province.The prospect area of hydrothermal copper deposit was determined. | Man WANG Linfu XUE Yingwei WANG | 2007 | Global Geology2007，10，1： | 1 |
| 18 | Non-seismic geophysical analysis of potential geothermal resources in the Longgang Block,Northeast China显示文摘Although geothermal energy has many clear advantages,including its sustainability and environmentally friendly nature,research into potential geothermal resources across the Longgang Block,Northeast China,has been limited.Here we present the first analysis of the potential geothermal resources in this region that employs joint geological and non-seismic geophysical methods to identify target areas that may be economically viable.We acquire and analyze high-precision gravity,magnetic,and magnetotelluric sounding data,which are constrained using the petrophysical parameters of outcropping rocks across the Longgang Block,to conduct a comprehensive evaluation of the region’s deep geological structures and their geothermal resources potential,with a focus on identifying faults,rock masses,and thermal storage structures.We find that Archean granitic gneiss and Mesozoic rock masses in the deeper section of the Longgang Block possess weak gravity anomalies and high resistivities.We also identify thermal storage structures near these deeper geological units based on their extremely low resistivities.The data are used to infer the dip and depth of known or hidden faults,to constrain the spatial distribution of intrusive rock masses,and to determine the spatial distribution of subsurface thermal storage structures.The potential of the target areas for geothermal resources exploitation is divided into three grades based on contact depths between faults and thermal storage structures,and the scale of their thermal storage structures.Our results suggest that a joint non-seismic geophysical approach can be effective in locating and evaluating geothermal resources in complex geological settings. | HaiYan Liu Chong Peng LinFu Xue WenQing Li ChunHui Xu Cremilda Samuel Jofrisse | 2022 | Earth and Planetary Physics2022，6，6： | 1 |
| 19 | Multiplex locked nucleic acid probes for analysis of hepatitis B virus mutants using real-time PCR显示文摘 | Zhen Sun Linfu Zhou Haiyan Zeng Zhi Chen Haihong Zhu | 2006 | Genomics2006，，1： | 1 |
| 20 | Numerical simulation of oil shale in-situ mining using fluid-thermo-solid coupling显示文摘For the in-situ gas-injection mining technology of oil shale by process,a numerical simulation method with flow-thermo-solid coupling is proposed in this paper.This method adopts separate simulations and step-by-step coupling simulation ideas combined with the advantages of the finite element method and the finite volume method.The numerical simulation of flow-thermo-solid coupling is decomposed into two parts:flow-solid coupling and thermo-solid coupling.Considering the Fuyu oil shale in-situ production test area in Songliao Basin as an example,it is concluded that the oil shale has undergone four heating stages:a rapid temperature rise,a steady temperature rise,a slow temperature rise,and heat preservation.It takes about 10 years for the stress-strain state of the oil shale layer to reach a steady-state through the thermo-solid coupling.The main strain zones of the oil shale layer are distributed near the fracturing fractures connected to the gas injection well and at the edge of the fracturing fractures.The areas with the plastic deformation in the oil shale layer predominantly appear near the gas injection wells,production wells,and fracturing channels.The areas with the largest fracture strength are mostly distributed near the edge of the fracturing fractures with low flow velocity and low temperature. | ZHANG Tiantong LIU Zeyu XIE Zhixian LI Yubo XUE Linfu | 2020 | Global Geology2020，23，4： | 1 |
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