|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Differential secretome analysis reveals CST6 as a suppressor of breast cancer bone metastasis显示文摘骨头转移从疾病是乳癌的经常的复杂并发症和病态和死亡的一个普通原因。在转移期间,分泌蛋白质在在癌症房间和主人基质之间的相互作用起关键作用。为了描绘分泌蛋白质,那与乳癌骨头转移被联系,我们比较四个 MDA-MB-231 (MDA231 ) 衍生物房间的 secretomes 的没有标签的 proteomic 分析与骨头转移的改变的能力衬里的 preformed。128 蛋白质的一个总数被发现是一致地在骨头回归线癌症房间的调节媒介的 up-/down-regulated。改变的蛋白质的充实的分子的函数包括了受体绑定和 peptidase 抑制。通过乳癌房间的另外的 transcriptomic 分析,我们选择了 cystatin E/M (CST6 ) ,在骨头变形的房间下面调整的一个半胱氨酸朊酶禁止者,为进一步功能的研究。我们的结果证明 CST6 压制了乳癌房间的增长,殖民地形成,迁居和侵略。对癌症房间活动性的镇压功能被癌症执行导出房间的可溶的 CST6。更重要地,在癌症房间的 CST6 的宫外的表示在动物学习救了老鼠免于公开 osteolytic 转移和死亡,当时 CST6 击倒的显著地提高的癌症房间骨头转移和弄短的动物幸存。总的来说,我们的学习提供了乳癌骨头向性的全身的 secretome 分析并且作为乳癌 osteolytic 转移的真正的 suppressor 建立了分泌 CST6。 | Lei Jin Yan Zhang Hui Li Ling Yao Da Fu Xuebiao Yao Lisa X Xu Xiaofang Hu Guohong Hu | 2012 | Cell Research2012，22，9： | 15 |
| 2 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 3 | 电位质子滴定与NEXAFS和XPS表征功能化多壁碳纳米管比较(英文)显示文摘Since the discovery of carbon nanotubes (CNT), this material has been recognized as an attractive catalyst support. CNT must be functionalized before use as a catalyst support and typically this involves oxidation. However, the functional group distribution on the CNT is very complex mixture of groups and varies with oxidation agent used. Here a simple acid-base titration is introduced to characterize the oxygen functionalized CNT. By comparing characterization with near-edge X-ray absorption fine structure (NEXAFS) and X-ray photoelectron spectroscopy (XPS) for both at the C and O K-edges, it can be demonstrated that potentiometric proton titration can be a fast and quantitative analysis for Brnsted acid functional groups on CNT. | Zhiteng Zhang Lisa Pfefferle Gary L.Haller | 2014 | 催化学报2014，35，6： | 3 |
| 4 | Technical comments on rodent spinal cord injuries models显示文摘Spinal cord injuries(SCI)in rodents have been created by laceration,contusion,compression,or intramedullary injection of toxic agents.The choice of an appropriate SCI model should be made for each study based on the experimental design,with care taken to avoid unintended complications such as hemorrhage.Technical comments will be made in this communication describing the 1)importance of vertebral stabilization,2)injury preparation,and 3)landmarks to improve the precision and reproducibility of the SCI. | Zoe Zhang Yi Ping Zhang Lisa B.E.Shields Christopher B.Shields | 2014 | Neural Regeneration Research2014，9，5： | 2 |
| 5 | Challenges and opportunities for managing pediatric central nervous system tumors in China显示文摘Central nervous system(CNS)tumors represent the most deadly cancer in pediatric age group.In China,thousands of children are diagnosed with CNS tumors every year.Despite the improving socioeconomic status and availability of medical expertise within the country,unique challenges remain for the delivery of pediatric neuro-oncology service.In this review,we discuss the existing hurdles for improving the outcome of children with CNS tumors in China.Need for precise disease burden estimation,lack of intra-and inter-hospital collaborative networks,high probability of treatment abandonment,along with financial toxicities from treatment represent the key challenges that Chinese healthcare providers encounter.The tremendous opportunities for advancing the status of pediatric neuro-oncology care in and beyond the country are explored. | Anthony Pak-Yin Liu Daniel CMoreira Chenchen Sun Lisa Krull Yijin Gao Bo Yang Chenran Zhang Kejun He Xiaojun Yuan Godfrey Chi-Fung Chan Xiaofei Sun Xiaoli Ma Ibrahim AQaddoumi | 2020 | Pediatric Investigation2020，4，3： | 2 |
| 6 | Dynamic glial response and crosstalk in demyelination-remyelination and neurodegeneration processes显示文摘Multiple sclerosis is an autoimmune disease in which the immune system attacks the myelin sheath in the central nervous system.It is characterized by blood-brain barrier dysfunction throughout the course of multiple sclerosis, followed by the entry of immune cells and activation of local microglia and astrocytes.Glial cells(microglia, astrocytes, and oligodendrocyte lineage cells) are known as the important mediators of neuroinflammation, all of which play major roles in the pathogenesis of multiple sclerosis.Network communications between glial cells affect the activities of oligodendrocyte lineage cells and influence the demyelination-remyelination process.A finely balanced glial response may create a favorable lesion environment for efficient remyelination and neuroregeneration.This review focuses on glial response and neurodegeneration based on the findings from multiple sclerosis and major rodent demyelination models.In particular, glial interaction and molecular crosstalk are discussed to provide insights into the potential cell-and molecule-specific therapeutic targets to improve remyelination and neuroregeneration. | Tianci Chu Lisa B.E.Shields Wenxin Zeng Yi Ping Zhang Yuanyi Wang Gregory N.Barnes Christopher B.Shields Jun Cai | 2021 | Neural Regeneration Research2021，16，7： | 2 |
| 7 | Objective assessment of cervical spinal cord injury levels by transcranial magnetic motor-evoked potentials显示文摘 | Christopher B. Shields Yi Ping Zhang Lisa B.E. Shields Darlene A. Burke Steven D. Glassman | 2006 | Surgical Neurology2006，，5： | 1 |
| 8 | Isolation, structure and biological activities of platencin A 2 –A 4 from Streptomyces platensis显示文摘 | Chaowei Zhang John Ondeyka Lisa Dietrich Francis P. Gailliot Michelle Hesse Michael Lester Karen Dorso Mary Motyl Sookhee N. Ha Jun Wang Sheo B. Singh | 2010 | Bioorganic & Medicinal Chemistry2010，，7： | 1 |
| 9 | Evaluation of alternate cooling and heating for tumor treatment显示文摘 | Sun Jianqi Zhang Aili Xu Lisa X | 2008 | International Journal of Heat and Mass Transter2008，，51： | 1 |
| 10 | A cycle augmentation algorithm for minimum cos t multicommodity flow on a ring显示文摘 | Sheperd Bruce Zhang Lisa | 2001 | Discrete Applied Mathematics2001，110，： | 1 |
| 11 | A cycle augmentation algorithm for minimum cost muhicommodity flow on a ring显示文摘 | Sheperd Bruce Zhang Lisa | 2001 | Discrete Applied Mathematics2001，110，： | 1 |
| 12 | Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists显示文摘 | Wei Wang Pratik Devasthale Dennis Farrelly Liqun Gu Thomas Harrity Michael Cap Cuixia Chu Lori Kunselman Nathan Morgan Randy Ponticiello Rachel Zebo Litao Zhang Kenneth Locke Jonathan Lippy Kevin O’Malley Vinayak Hosagrahara Lisa Zhang Pathanjali Kadiyala | 2008 | Bioorganic & Medicinal Chemistry Letters2008，，6： | 1 |
| 13 | Elevated systemic expression of ER stress related genes is associated with stress-related mental disorders in the Detroit Neighborhood Health Study 显示文摘 | Lisa Nevell Zhang Ke-zhong Allison E Aiello | 2014 | Psychoneuroendocrinology2014，43，： | 1 |
| 14 | Isoflurane-Induced Neuronal Degeneration: An Evaluation in Organotypic Hippocampal Slice Cultures显示文摘 | Lisa Wise-Faberowski Haito Zhang Richard Ing Robert D. Pearlstein David S. Warner | 2005 | Anesthesia & Analgesia2005，，3： | 1 |
| 15 | Theoretical analysis and simulation of InP-based uni-traveling-carrier photodetector显示文摘In this paper the photocurrent response of InP-based unitraveling-carrier photodetectors(UTC-PDs) is analyzed using the drift-diffusion approach.Based on the theoretical analysis,an InP/InGaAs UTC-PD is modeled utilizing a numerical device simulator(ATLAS),and the physics of the device's operation and its performance as a function of biasing and power level are simulated.The simulation results indicate that the linear dynamic range is up to 60 mW,the f-3 dB is about 40 GHz and the full-width at half-maximum(FWHM) of the current pulse is 28 ps with 10 mW optical power injection for an optimized structure UTC-PD. | XIE Sheng LIU LiSa KANG WenPing SONG RuiLiang MAO LuHon ZHANG ShiLin | 2009 | Chinese Science Bulletin2009，54，20： | 1 |
| 16 | QoS Routing with Performance-Dependent Costs显示文摘 | Funda Ergun Rakesh Sinha Lisa Zhang | 2000 | Infocom2000，，： | 1 |
| 17 | The Impact of Basic-Level Parent Engagements on Student Achievement:Patterns Associated with Race/Ethnicity and Socioeconomic Status(SES)显示文摘 | Dalun Zhang Hsien-Yuan Hsu Oi-man Kwok Michael Benz Lisa Bowman-Perrott | | 0，，1： | 1 |
| 18 | Thyroid cancer gender disparity显示文摘 | Rahbari R Zhang Lisa Kebebew E | 2010 | Future Oncol2010，6，11： | 1 |
| 19 | Orthogonal, convergent syntheses of dendrimers based on melamine with one or two unique surface sites for manipul-ation 显示文摘 | Zhang Wen Daniel T Nowlan Lisa M Thomson | 2001 | J Am Chem Soc2001，12，： | 1 |
| 20 | Relationship Between Level of Hepatitis B Virus DNA and Liver Disease: A Population-based Study of Hepatitis B e Antigen–Negative Persons With Hepatitis B显示文摘 | Brian J. McMahon Lisa Bulkow Brenna Simons Yuhong Zhang Susan Negus Chriss Homan Philip Spradling Eyasu Teshale Daryl Lau Mary Snowball Stephen E. Livingston | 2014 | Clinical Gastroenterology and Hepatology2014，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员