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| 1 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 2 | Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver显示文摘AIM To compare the effects of liposomes andglyco-poly-L-lysine on liver targeted uptake andexpression of plasmid in rat liver.METHODS After binding with lipofectamine orgalactose-terminal glyco-poly-L-lysine,theplasmid could be expressed in eukaryotic cellswhen injected into Wistar rats by intravenousroute.At different time intervals after the injection,the distribution and expression of the plasmid inliver of rats were observed and compared using insitu hybridization and immunohistochemistry.RESULTS The expression of the plasmid bindingto liposomes or G-PLL could be markedly observed24 h later,and began to decrease one week later,but it still could be observed up to three weeks.Both liposomes and G-PLL could deliver theplasmid to the liver effectively,but the effect of thelatter was better than the former concerning thedistribution and expression of the plasmid targeteduptake in the liver.CONCLUSION G-PLL is better than liposome asthe targeted carrier for delivering exogenous genesto the liver. | Yang, CQ Wang, JY He, BM Liu, JJ Guo, JS | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 3 | Habitat suitability of Scapharca subcrenata (Lischke) inthe shallow water of the Xiaoheishan Island显示文摘The habitat suitability index(HSI) model was used to identify potential sites for sustainable restoration of ark shell, Scapharca subcrenata(Lischke), in the shallow water of Xiaoheishan Island, using a geographic information system framework. The seven input variables of the HSI model were sediment composition, water temperature, salinity, dissolved oxygen, water depth, p H, and ammonia. A non-linear suitability function for each variable factor was used to transform the value into a normalized quality index ranging from 0(nonsuitability) to 1(best suitability). In present study, the analysis of habitat suitability was conducted for four seasons respectively. The majority of the study area has a high HSI value(>0.6) year round, which implies a strong suitability for restoration, with the optimal habitat located on the eastern side of the island.Correspondence analysis indicated that water temperature was the main factor causing seasonal variation,while sediment composition and water depth were the two major reasons for the differences in sites. The results of this work could provide support for restoration decision making through identification of potential sites for sustainable establishment of S. subcrenata. | ZHOU Jian SONG Jingjing BM Qianling LIU Chengyue ZHANG Zhipeng TANG Haitian | 2016 | Acta Oceanologica Sinica2016，35，12： | 2 |
| 4 | MR imaging and CT of the biliary tract显示文摘 | Yeh BM Liu PS Soto JA | 2009 | Radiographics2009，29，： | 1 |
| 5 | Differentiation of islet cells in long-term culture 显示文摘 | Schmied BM Liu G Matsuzaki H | 2000 | Pancreas2000，20，4： | 1 |
| 6 | Efficacy of postoper- ative epidural analgesia: a meta-analysis显示文摘 | Block BM Liu SS Rowlingson AJ | 2003 | JAMA2003，290，18： | 1 |
| 7 | PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a) 显示文摘 | Emerling BM Weinberg F Liu JL | 2008 | Proc NatlAcadSciUSA2008，105，7： | 1 |
| 8 | PTEN regulates p300 - dependent hypoxia - inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a) 显示文摘 | Emeding BM Weinberg F Liu JL | 2008 | Proc Natl Acad Sci USA2008，105，7： | 1 |
| 9 | PTEN regulates p300- dependent hypoxia- inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a)显示文摘 | Emerling BM Weinberg F Liu JL | 2008 | Proc Natl Acad Sci USA2008，105，7： | 1 |
| 10 | Association of right-to- left shunt with frontal white matter lesions in T2- weighted MR imaging of stroke patients显示文摘 | Liu JR Plotz BM Rohr A | 2009 | Neuroradiology2009，51，5： | 1 |
| 11 | Excerpts from US Renal Data System2009Annual Data Report显示文摘 | Collins AJ Foley RN Herzog C Chavers BM Gilb-ertson D Ishani A Kasiske BL Liu J Mau LW Mc-Bean M | 2010 | Am J Kidney Dis2010，55，： | 1 |
| 12 | PTEN regulates p300 - dependent hypoxia - inducible factor 1 transcrip- tional activity through Forkhead transcription factor 3a (FOXO3a) 显示文摘 | Emerling BM Weinberg F Liu JL | 2008 | Proc Natl Acad Sci USA2008，105，7： | 1 |
| 13 | Matrix metalloproteinase-ac- tivated anthrax lethal toxin demonstrates high potency in targe- ting tumor vasculature显示文摘 | Liu S Wang H Currie BM | 2008 | J Biol Chem2008，283，1： | 1 |
| 14 | Efficacy of post- operative epidural analgesia: A meta-analysis 显示文摘 | Block BM Liu SS Rowlingson AJ | 2003 | JAMA2003，290，： | 1 |
| 15 | Oxidized-LDL through LOX-1 increases the expression of angiotensin converting enzyme in human coronary artery endothelial cell显示文摘 | Li D Singh RM Liu L Chen H Singh BM Kazzaz N | 2003 | Cardiovasc Res2003，57，1： | 1 |
| 16 | Local adipocytes enable estrogen- dependent breast cancer growth : role of leptin and aromatase 显示文摘 | Liu E Samad F Mueller BM | 2013 | Adipocyte2013，2，3： | 1 |
| 17 | Transplantation of mesenchymal stem cells is an optimal approach for plastic surgery显示文摘 | Fang D Seo BM Liu Y | 2007 | Stem Cells2007，25，4： | 1 |
| 18 | Efficacy of postoperative epidural显示文摘 | Liu SS Rowlingson AJ | 2003 | JAMA2003，290，： | 1 |
| 19 | Transcatheter arterial embolization in the emergency Department for hemodynamic instability due to ruptured hepatocellular carcinoma:analysis of 167 cases显示文摘 | Kung CT Liu BM Ng SH | | 0，，： | 1 |
| 20 | Yak introgression into Tibetan yellow cattle:evidences from mtDNA D-loop sequence analysis and β-lactoglobulin genetic variants显示文摘 | Liu ZX Lu BM Mao YJ | | 0，，09： | 1 |
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