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| 1 | Waveguide invariant estimation in elastic Pekeris waveguide显示文摘Focus on sound intensity,particle velocity,complex sound intensity and waveguide impedance,the formation mechanism of interference structures in range-frequency domain for the above four kinds of physical quantities in Pekeris waveguides is analyzed based on Normal Mode Theory.Also,a sea-trial with broadband radiated source is conducted to verify the analysis results.Both the simulation results and the analysis of sea-trial data indicate that,in range-frequency domain,the four kinds of physical quantities will exhibit a stable interference structure which can be expressed with waveguide invariant β.Among these quantities,the coherent components of complex sound intensity can better reflect the interference characteristics of the waveguide.Finally,a multi-scale linear filter is introduced to deal with the sea-trial LOFAR(Low Frequency Analysis Recording) spectrum,the processing results show that the proposed filter can effectively enhance the interference characteristics in images,and conductively detect and extract striations' information from interference structures in LOFAR spectrum. | ZHU Hanhao PIAO Shengchun ZHANG Haigang LIU Wei | 2017 | Chinese Journal of Acoustics2017，36，1： | 3 |
| 2 | Frequency domain polarization weighted ESPRIT method for bearing angle显示文摘The signal to noise ratio(SNR) of seismic waves is usually very low after long distance transmission. For this condition, to improve the bearing estimation capability in the low SNR,a frequency domain polarization weighted ESPRIT method using a single vector device is proposed. The frequency domain polarization parameters extracted from the signals are used to design the weighted function which is applied to the received signals. The bearing angle and the target frequency are estimated through ESPRIT using the weighted signals. The simulation and experiment results show that the presented method can obtain accurate estimation values under the low SNR with little prior information. | Wei Liu Shengchun Piao Junyuan Guo Qingxin Meng Hanhao Zhu | 2014 | Journal of Systems Engineering and Electronics2014，25，5： | 2 |
| 3 | Noninvasive mechanical auxiliary circulation(NMAC):A general concept and the technological trends显示文摘A series of noninvasive mechanical auxiliary circulation(NMAC)technologies,such as intermittent pneumatic compression(IPC),external counterpulsation(ECP),and anti-G suit,had been widely used to realize noninvasive intervention of human cardiovascular system for different purposes,such as treatments of cardiovascular diseases and protecting pilot from G-induced loss of consciousness(G-LOC)during exposure to sustained accelerations.There are lots of similarities among these NMAC technologies,especially on aspects of hardware constitutions and their physiological effects.However,these technologies were almost independently developed in the past few decades.The similarities and differences were summarized on aspects of hardware constitutions and physiological effects of IPC,ECP and anti-G suit in this paper,and a general concept for NMAC technologies was proposed.This concept did not include a restrict definition,but generally focused on the physiological benefits,while any noninvasive mechanical methods that can achieve such benefits are welcomed.Trends for these typical NMAC technologies,especially about the strategies to realize personalized therapy or to meet new challenges,are discussed.This paper provided a unified perspective for non-invasive mechanical technologies aiming at cardiovascular benefits,and might inspire new technologies to be introduced in. | Wang Yawei Li Jianchao Wang Bitian Liu Hanhao Wu Guifu Fan Yubo | 2022 | Medicine in Novel Technology and Devices2022，，4： | 0 |
| 4 | SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer显示文摘Lymph node(LN)metastasis is one of the predominant metastatic routes of non-small cell lung cancer(NSCLC)and is considered as a leading cause for the unsatisfactory prognosis of patients.Although lymphangiogenesis is well-recognized as a crucial process in mediating LN metastasis,the regulatory mechanism involving lymphangiogenesis and LN metastasis in NSCLC remains unclear.In this study,we employed high-throughput sequencing to identify a novel circular RNA(circRNA),circTLCD4-RWDD3,which was significantly upregulated in extracellular vesicles(EVs)from LN metastatic NSCLC and was positively associated with deteriorated OS and DFS of patients with NSCLC from multicenter clinical cohort.Downregulating the expression of EV-packaged circTLCD4-RWDD3 inhibited lymphangiogenesis and LN metastasis of NSCLC both in vitro and in vivo.Mechanically,circTLCD4-RWDD3 physically interacted with hnRNPA2B1 and mediated the SUMO2 modification at K108 residue of hnRNPA2B1 by upregulating UBC9.Subsequently,circTLCD4-RWDD3-induced SUMOylated hnRNPA2B1 was recognized by the SUMO interaction motif(SIM)of ALIX and activated ALIX to recruit ESCRT-III,thereby facilitating the sorting of circTLCD4-RWDD3 into NSCLC cell-derived EVs.Moreover,EV-packaged circTLCD4-RWDD3 was internalized by lymphatic endothelial cells to activate the transcription of PROX1,resulting in the lymphangiogenesis and LN metastasis of NSCLC.Importantly,blocking EV-mediated transmission of circTLCD4-RWDD3 via mutating SIM in ALIX or K108 residue of hnRNPA2B1 inhibited the lymphangiogenesis and LN metastasis of NSCLC in vivo.Our findings reveal a precise mechanism underlying SUMOylated hnRNPA2B1-induced EV packaging of circTLCD4-RWDD3 in facilitating LN metastasis of NSCLC,suggesting that EV-packaged circTLCD4-RWDD3 could be a potential therapeutic target against LN metastatic NSCLC. | Xiayao Diao Chao Guo Hanhao Zheng Ke Zhao Yuming Luo Mingjie An Yan Lin Jiancheng Chen Yuanlong Li Yuting Li Xuehan Gao Jiaqi Zhang Mengxin Zhou Wenliang Bai Lei Liu Guige Wang Lanjun Zhang Xiaotian He Rusi Zhang Zhihua Li Changhao Chen Shanqing Li | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 5 | Research on sound velocity measurement in a laboratory for large elastic materials显示文摘A measurement scheme carried out in a tank is designed to obtain the compressionaland shear-wave velocities of a large elastic material.A hydrophone is used to receive the high frequency acoustic signals which penetrate the tested material,in order to determine the transmission time from the source to the hydrophone,the transmission time is also calculated according to the ray acoustic theory in layered media.A cost function is built based on the measured and the calculated transmission time,then the compressional- and shear-wave velocities can be obtained using the optimization algorithm.Compared with the traditional measurement scheme,this approach can not only get the 2 kinds of sound velocities in the tested material at the same time,but also keep the integrality of the tested material.With the proposed measurement system,the uncertainty of measurement results is less than 3.5%. | ZHU Hanhao PIAO Shengchun ZHANG Haigang LIU Wei AN Xudong | 2014 | Chinese Journal of Acoustics2014，33，2： | 0 |
| 6 | Multi‑compartment Organ‑on‑a‑Chip Based on Electrospun Nanofber Membrane as In Vitro Jaundice Disease Model显示文摘Organ-on-a-chip(OOC)is now becoming a potential alternative to the classical preclinical animal models,which reconstitutes in vitro the basic function of specifc human tissues/organs and dynamically simulates physiological or pathological activities in tissue and organ level.Despite of the much progress achieved so far,there is still an urgent need to explore new biomaterials to construct a reliable and efcient tissue-tissue interface and a general fabrication strategy to expand from single-organ OOC to multi-organ OOC in an easy manner.In this paper,we propose a novel strategy to prepare doublecompartment organ-on-a-chip(DC-OOC)using electrospun poly(l-lactic acid)/collagen I(PLLA/Col I)nanofber membrane as tissue-tissue interface.The unique features of PLLA/Col I nanofber membrane like excellent biocompatibility,strong afnity to multiple cells,adjustable orientation,controllable thickness and porosity endow the tissue-tissue interface with excellent semi-permeability,appropriate mechanical support,inducible cell orientation,good cell adhesion and proliferation.The integration of 3D printing technology during the fabrication process enables precise size control of the tissue-tissue interface and stable bonding with microfuidic channels.More importantly,our fabrication strategy and OOC confguration makes it easy to extend from DC-OOC to multi-compartment organ-on-a-chip(MC-OOC).To show its possible application,in vitro jaundice disease model is established by constructing blood vessel/skin/liver/lung organ-on-a-chip via MC-OOC.The downward trends of the cell viability after perfusion of bilirubin,the variation in cell sensitivity to bilirubin for diferent type of cells and recovery of cell viability after blue light therapy prove the feasibility of this jaundice disease model.We believe this general strategy of constructing tissue-tissue interface and multi-organ OOC can be used for many other in vitro physiological and pathological models. | Fan Lei Minhua Liang Yang Liu Hanhao Huang Haofei Li Hua Dong | 2021 | Advanced Fiber Materials2021，3，6： | 0 |
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