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| 1 | G-CSF is a key modulator of MDSC and could be a potential therapeutic target in colitis-associated colorectal cancers显示文摘Granulocyte 刺激殖民地的因素(G-CSF ) 是嗜中性的 trafficking 的一个必要管理者并且高度在多重肿瘤被表示。Myeloid 导出 suppressor 房间(MDSC ) 由有免疫力的抑制通过多重机制支持肿瘤的前进。尽管有在结肠癌前进的 G-CSF 功能的调查结果, MDSC 规定上的 G-CSF 和它肿瘤生长上的封锁效果的精确机制仍然是调查的一个相称的区域。在这研究,我们在一只老鼠观察了 G-CSF 的 overexpression 联系大肠炎的癌症(CAC ) 当模特儿,它与在老鼠结肠纸巾的 MDSC 的累积一致。进一步,在 vitro,研究证明 G-CSF 能通过信号变换器和表明小径的抄写 3 的使活跃之物(STAT3 ) 支持 MDSC 幸存和激活。而且与适应于不同地区生活的动物控制相比, anti-G-CSF mAb 治疗表明了减少的 MDSC 累积,它在鼠标在瘤尺寸和数字导致了显著减少。我们的结果显示 G-CSF 是在迁居,增长和 MDSC 的功能维护的一个批评调整分子,它能是为联系大肠炎的癌症的一个潜在的治疗学的目标。 | Wenbin Li Xinghua Zhang Yongkang Chen Yibin Xie Jiancheng Liu Qiang Feng Yi Wang Wei Yuan Jie Ma | 2016 | Protein & Cell2016，7，2： | 29 |
| 2 | Progresses on microwave remote sensing of land surface parameters显示文摘Highly accurate observations at various scales on the land surface are urgently needed for the studies of many areas,such as hydrology,meteorology,and agriculture.With the rapid development of remote sensing techniques,remote sensing has had the capacity of monitoring many factors of the Earth's land surface.Especially,the space-borne microwave remote sensing systems have been widely used in the quantitative monitoring of global snow,soil moisture,and vegetation parameters with their all-weather,all-time observation capabilities and their sensitivities to the characteristics of land surface factors.Based on the electromagnetic theories and microwave radiative transfer equations,researchers have achieved great successes in the microwave remote sensing studies for different sensors in recent years.This article has systematically reviewed the progresses on five research areas including microwave theoretical modeling,microwave inversion on soil moisture,snow,vegetation and land surface temperatures.Through the further enrichment of remote sensing datasets and the development of remote sensing theories and inversion techniques,remote sensing including microwave remote sensing will play a more important role in the studies and applications of the Earth systems. | SHI JianCheng DU Yang DU JinYang JIANG LingMei CHAI LinNa MAO KeBiao XU Peng NI WenJian XIONG Chuan LIU Qiang LIU ChenZhou GUO Peng CUI Qian LI YunQing CHEN Jing WANG AnQi LUO HeJia WANG YinHui | 2012 | Science China Earth Sciences2012，55，7： | 24 |
| 3 | Atomic spin gyroscope based on 129Xe-Cs comagnetometer显示文摘Atomic spin gyroscope (ASG) based on comagnetometer is a high sensitive and compact gyroscope for future inertial navigation applications. The start-up time was several hours of the demonstrated ASGs based on 3He-K or21 Ne-Rb-K comagnetometer, and only a few inertial navigation applications allow such a long time for preparation. We report the demonstration of an ASG based on 129Xe-Cs comagnetometer, which decreases the start-up time to 10 minutes and decreases the operation temperature by 40% as well. By operating this ASG in spin exchange relaxation free regime, a sensitivity of 7×10 -5 °/(s Hz1/2) was achieved. | FANG JianCheng QIN Jie WAN ShuangAi CHEN Yao LI RuJie | 2013 | Chinese Science Bulletin2013，58，13： | 19 |
| 4 | Field-observation for an anticyclonic mesoscale eddy consisted of twelve gliders and sixty-two expendable probes in the northern South China Sea during summer 2017显示文摘An intensive field observation experiment using 12 Chinese gliders equipped with conductivity-temperature-depth (CTD) sensors and 62 expendable CTD probes (XCTDs) was performed to investigate the 3-D structure and time evolution of an anticyclonic eddy in the northern South China Sea (NSCS). The observed results showed that the anticyclonic eddy had a horizontal radius of about 80 km at surface and a vertical depth of impact of more than 1000 m. The largest temperature and salinity anomalies compared with the averaged values of the temperature and salinity profiles were 3.5°C and 0.4 psu at 120 m depth, respectively. Combined analysis of altimeter sea level and water mass properties indicated that the anticyclonic eddy was shed from the Kuroshio loop current. The vertical axis of the anticyclonic eddy tilted from surface to the observed maximum depth (1000 m) along its translation direction against the 2000 m isobath. The center of the anticyclonic eddy remained in the region east of Dongsha Island for more than half a month. During this time, the long axis direction of the eddy changed from across the slope to along the slope. Then, the eddy moved southward along the 2000 m isobaths. Both the geostrophic current and temperature distribution revealed that the eddy intensity weakened during the observation period gradually. These observations indicated strong interaction between the anticyclonic eddy and the slope topography of Dongsha Island. | Yeqiang SHU Ju CHEN Shuo LI Qiang WANG Jiancheng YU Dongxiao WANG | 2019 | Science China Earth Sciences2019，62，2： | 19 |
| 5 | A review of the estimation of downward surface shortwave radiation based on satellite data:Methods, progress and problems显示文摘The estimation of downward surface shortwave radiation(DSSR)is important for the Earth’s energy budget and climate change studies.This review was organised from the perspectives of satellite sensors,algorithms and future trends,retrospects and summaries of the satellite-based retrieval methods of DSSR that have been developed over the past 10 years.The shortwave radiation reaching the Earth’s surface is affected by both atmospheric and land surface parameters.In recent years,studies have given detailed considerations to the factors which affect DSSR.It is important to improve the retrieval accuracy of cloud microphysical parameters and aerosols and to reduce the uncertainties caused by complex topographies and high-albedo surfaces(such as snow-covered areas)on DSSR estimation.This review classified DSSR retrieval methods into four categories:empirical,parameterisation,look-up table and machine-learning methods,and evaluated their advantages,disadvantages and accuracy.Further efforts are needed to improve the calculation accuracy of atmospheric parameters such as cloud,haze,water vapor and other land surface parameters such as albedo of complex terrain and bright surface,organically combine machine learning and other methods,use the new-generation geostationary satellite and polar orbit satellite data to produce highresolution DSSR products,and promote the application of radiation products in hydrological and climate models. | Husi LETU Jiancheng SHI Ming LI Tianxing WANG Huazhe SHANG Yonghui LEI Dabin JI Jianguang WEN Kun YANG Liangfu CHEN | 2020 | Science China Earth Sciences2020，63，6： | 8 |
| 6 | Kuroshio intrusion into the South China Sea with an anticyclonic eddy: evidence from underwater glider observation显示文摘In this study, high-resolution temperature and salinity data obtained from three Sea-Wing underwater gliders were used together with satellite altimeter data to track the vertical thermohaline structure of an anticyclonic eddy that originated from the loop current of the Kuroshio southwest of Taiwan, China. One of the gliders crossed the entire eddy and it observed a remarkable warm anomaly of as much as 3.9℃ extending to 500 dbar from the base of the mixed layer. Conversely, a positive salinity anomaly was found to be above 200 dbar only in the anticyclonic eddy, with a maximum value of >0.5 in the mixed layer. Below the mixed layer, water of higher salinity (>34.7) was found, which could have been preserved through constrained vertical mixing within the anticyclonic eddy. The salinity in the upper layer of the anticyclonic eddy was much similar to that of the northwestern Pacific Ocean than the northern South China Sea, reflecting Kuroshio intrusion with anticyclonic eddy shedding from the loop current. | LIU Zenghong CHEN Xingrong YU Jiancheng XU Dongfeng SUN Chaohui | 2019 | Journal of Oceanology and Limnology2019，37，5： | 7 |
| 7 | Determination of the ^(12)C(p, γ)^(13)N reaction rates fromthe ^(12)C(~7Li,~6He)^(13)N reaction显示文摘The angular distribution of the 12C(7Li,6He)13N reaction at E(7Li) = 44.0 MeV was measured at the HI-13 tandem accelerator of Beijing, China. The asymptotic normalization coefficient (ANC) of 13N → 12C + p was derived to be (1.64 ± 0.11) fm-1/2 through the distorted wave Born approximation (DWBA) analysis. The ANC was then used to deduce the astrophysical S (E) factors and reaction rates for the 12C(p,γ)13N direct capture reaction at energies of astrophysical relevance. | LI ZhiHong, SU Jun, GUO Bing, LI ZhiChang, BAI XiXiang, LIU JianCheng, LI YunJu, YAN ShengQuan, WANG BaoXiang, WANG YouBao, LIAN Gang, ZENG Sheng, LI ErTao, CHEN YongShou, SHU NengChuan, FAN QiWen & LIU WeiPing China Institute of Atomic Energy, Beijing 102413, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，4： | 6 |
| 8 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 9 | Facile Synthesis of Cellulose Acetate Ultrafiltration Membrane with Stimuli-Responsiveness to pH and Temperature Using the Additive of F127-b-PDMAEMA显示文摘 | Naixu Li Jun Yin LingfeiWei Quanhao Shen Wei Tian Jing Li Yong Chen Jing Jin Hongcheng Teng Jiancheng Zhou | 2017 | Chinese Journal of Chemistry2017，35，7： | 4 |
| 10 | The principle of measuring unusual change of underground mass by optical astrometric instrument显示文摘Optical observations from a ground-based astrometric instrument provide a unique set of data sensitive to variations of local plumb line, which represent the change of local gravitational field on the ground. The local gravitational change could be caused by density variation or movement of underground mass in addition to tidal action. Earthquake was found to be related with gravitational change. A seismic zone could have abnormal underground material density, causing the variation of plume line on the ground. In this frame, the astrometric telescope can measure the variation of local plumb line by observing the local astronomical longitudes and latitudes from stars in the Hipparcos catalog. In this study, we estimate the deflection angle of the plumb line on a ground site, and give a relation between the angle, abnormal mass and site distance (depth and horizontal distance). Then we derive the abnormality of underground material density using the plumb lines measured at different sites, and study the earthquake gestation, development and occurrence. Using the deflection angles of plumb lines observed at two sites, we give a method to calculate the mass and the center of gravity of underground materials. We also estimate the abnormal masses of latent seismic zones with different energy, using thermodynamic relations, and introduce a new optical astrometric instrument we had developed. | Wang Jiancheng Chen Linfei Yang Lei Cheng Xiangming Su Jie Li Binghua Mao Wei Tie Qiongxian | 2012 | Geodesy and Geodynamics2012，3，4： | 4 |
| 11 | Determination of the degree 120 time-variable gravity field in the Sichuan-Yunnan region using Slepian functions and terrestrial measurements显示文摘The terrestrial time-variable gravity measurements are characterized by a high signal-to-noise ratio and sensitivity to the sources of mass change in the Earth's crust.These gravity data have many applications,such as surface deformation,groundwater storage changes,and mass migration before and after earthquakes.Based on repeated terrestrial gravity measurements at 198 gravity stations in the Sichuan-Yunnan region(SYR)from 2015 to 2017,we determine a time series of degree 120 gravity fields using the localized spherical harmonic(Slepian)basis functions.Our results show that adopting the first 6 Slepian basis functions is sufficient for effective localized Slepian modeling in the SYR.The differences between two gravity campaigns at the same time of year show an obvious correlation with tectonic features.The degree 120 timevariable gravity models presented in this paper will benefit the study of the regional mass migration inside the crust of the SYR and supplement the existing geophysical models for the China Seismic Experimental Site. | Jiancheng Han Shi Chen Zhaohui Chen Hongyan Lu Weimin Xu | 2021 | Earthquake Science2021，34，3： | 4 |
| 12 | Neutron halo state of ^(13)C显示文摘Angular distributions for the 12C(d, p)13C transfer reactions have been measured at Ed = 11.8 MeV, and compared with those of the DWBA calculations. By means of this comparison, density distributions of the last neutron in the ground state and the first 1/2+ state of 13C are extracted. The properties of these states in 13C have also been studied in the framework of the nonlinear relativistic mean-field theory with NL-SH parameters. It is found that the first l/2+ state in 13C is a neutron halo state shown by both the experimental and theoretical density distributions of the last neutron. | LIU Zuhua, LIN Chengjian, LI Zhichang, ZHANG Huanqiao, CHEN Baoqiu, MA Zhongyu, WU Yuewei, LIU Jiancheng & LI ShuyuanChina Institute of Atomic Energy, Beijing 102413, China | 2001 | Chinese Science Bulletin2001，46，1： | 3 |
| 13 | Spacecraft angular velocity estimation method using optical flow of stars显示文摘Angular velocity is a crucial parameter for spacecraft navigation, which, at present, is mainly obtained by using gyroscopes. Several studies have been performed on angular velocity estimation using star sensors when data from gyroscopes are not available. Most of the previous angular velocity estimation methods using star sensors are based on information on the attitude or star vector measurements. In this paper,an angular velocity estimation method using the optical flow(OF) directly from the star images is proposed,which, unlike the previous methods, requires star coordinates in two consecutive images only. Because the procedure of star identification is eliminated, the corresponding high computation requirement is reduced.Simulations demonstrate that the proposed method has a robust performance in terms of computational cost and the number of stars in the field of view(FOV) compared with the previous methods. Finally, certain affecting factors are analyzed, including lens distortion, star senor instantaneous FOV(IFOV), star number,and accuracy of the star sensor. | Xiaolin NING Zonghe DING Pingping CHEN Weiren WU Jiancheng FANG Gang LIU | 2018 | Science China(Information Sciences)2018，61，11： | 3 |
| 14 | Traditional Chinese Medicine symptom pattern analysis for Parkinson's disease显示文摘OBJECTIVE: To use the theory of Traditional Chinese Medicine to identify the major symptom patterns of Parkinson's disease.METHODS: Journal databases were searched for relevant articles in the last 30 years. Articles were reviewed for symptom patterns of Parkinson's disease and analyzed using frequency analysis, cluster analysis, and other methods of data extraction.RESULTS: The analyses indicated that the most frequent symptom patterns of Parkinson's disease are Yin deficiency of kidney and liver, deficiency of Qi and blood, phlegm heat and wind stirring, blood stasis and wind stirring, and deficiency of Yin and Yang.CONCLUSION: Taken together, the analyses identified the primary symptom patterns of Parkinson's disease as Yin deficiency of kidney and liver, deficiency of Qi and blood, phlegm heat and wind stirring, and blood stasis and wind stirring. | Chen Hongzhi He Jiancheng Teng Long Yuan Canxing Zhang Zhe | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 3 |
| 15 | Whole-Genome Sequences Analysis Displays Relationship of SARS-CoV-2 Delta Variant Between Four Local Cases and Passengers of a Flight from South Africa—Shenzhen City,Guangdong Province,China,June 2021显示文摘On June 14,2021,a customs officer(Case A)went to the infirmary at Baoan International Airport in Shenzhen due to a runny nose and fever.He was admitted to the Central Hospital of Baoan immediately.This patient preliminarily tested positive for coronavirus disease 2019(COVID-19)infection,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),using a quantitative realtime reverse transcription polymerase chain reaction(qRT-PCR)method in this hospital.Then,a mixed specimen of nasopharyngeal swab. | Yaqing He Renli Zhang Qiuying Lyu Bo Peng Shujiang Mei Ying Sun Dongfeng Kong Chaoqiong Peng Ziquan Lyu Xinyi Wei Can Zhu Xiaoliang Xiao Shimin Li Qingju Lu Jiancheng Chen Hang Zhang Xuan Zou Tiejian Feng Long Chen | 2021 | China CDC weekly2021，3，50： | 3 |
| 16 | A transfer alignment method for airborne distributed POS with three-dimensional aircraft flexure angles显示文摘An airborne distributed position and orientation system(POS) appears to satisfy the requirement of multi-point motion parameters measurement. This relies on transfer alignment from a high precision master system to slave systems to obtain high accuracy motion parameters of all points. A key problem for a distributed POS involves determining a method to treat the aircraft flexure appropriately and achieve high precision transfer alignment. In this study, the effect of aircraft flexure on transfer alignment accuracy for airborne earth observation is first analyzed. Based on this, the error model of transfer alignment that considers three-dimensional flexure angles are established, and a transfer alignment based on parameter identification unscented Rauch-Tung-Striebel smoother(PIURTSS) is proposed. The simulations results show that the transfer alignment method based on PIURTSS effectively improves the estimation accuracy. | Xiaolin GONG Longjun CHEN Jiancheng FANG Gang LIU | 2018 | Science China(Information Sciences)2018，61，9： | 2 |
| 17 | Measuring the innovation production process: A cross-region empirical study of China’s high-tech innovations显示文摘 | Jiancheng Guan Kaihua Chen | 2010 | Technovation2010，，5： | 2 |
| 18 | Valuation of forest carbon sinks in China within the framework of the system of national accounts显示文摘为了更好支持森林资源管理并且加强森林碳的开发,压制 marketization,这份报纸在中国从最近的森林资源库存基于国家帐号(SNA ) 和数据的一个系统从 2003 ~ 2008 学习了森林碳水池的财务。学习在 RMB 817.13 的一个总数计算了森林碳股票的价值 ? 映吗? | Ying Zhang Jiancheng Chen Mingxing Hu Armin Offer | 2016 | Journal of Forestry Research2016，27，6： | 2 |
| 19 | Smart drug delivery systems for precise cancer therapy显示文摘Nano-drug delivery strategies have been highlighted in cancer treatment, and much effort has been made in the optimization of bioavailability, biocompatibility, pharmacokinetics profiles, and in vivo distributions of anticancer nano-drug delivery systems. However, problems still exist in the delicate balance between improved anticancer efficacy and reduced toxicity to normal tissues, and opportunities arise along with the development of smart stimuli-responsive delivery strategies. By on-demand responsiveness towards exogenous or endogenous stimulus, these smart delivery systems hold promise for advanced tumor-specificity as well as controllable release behavior in a spatial-temporal manner. Meanwhile, the blossom of nanotechnology, material sciences, and biomedical sciences has shed light on the diverse modern drug delivery systems with smart characteristics, versatile functions, and modification possibilities. This review summarizes the current progress in various strategies for smart drug delivery systems against malignancies and introduces the representative endogenous and exogenous stimuli-responsive smart delivery systems. It may provide references for researchers in the fields of drug delivery, biomaterials, and nanotechnology. | Xiaoyou Wang Chong Li Yiguang Wang Huabing Chen Xinxin Zhang Cong Luo Wenhu Zhou Lili Li Lesheng Teng Haijun Yu Jiancheng Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 2 |
| 20 | Microarray expression profile and functional analysis of circular RNAs in choroidal neovascularization显示文摘Choroidal neovascularization(CNV) is a leading cause of visual loss in age-related macular degeneration(AMD). However, the molecular mechanism for CNV progression is still unclear. This study aimed to identify CNV-related circular RNAs(circRNAs), a novel class of non-coding RNAs with diverse functions. A total of 117 circRNAs were differentially expressed in the murine CNV model by microarrays. Gene ontology(GO)enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis were performed to identify the functions of selected circRNAs. The host genes of these circRNAs were predicted to be targeted to neurogenesis(ontology: biological process), proteinaceous extracellular matrix(ECM)(ontology: cellular component), and binding(ontology: molecular function). Differentially expressed circRNAs-mediated regulatory networks were enriched in ECM receptor interaction. Most of the dysregulated circRNAs could potentially bind to five different mi RNAs by Target Scan and mi Randa. Specifically, circ_15752 was identified in this circRNAs pool which may facilitate vascular endothelial cell proliferation, migration, and tube formation, suggesting a critical role in endothelial angiogenesis. Our work suggests that dysregulated circRNAs may be involved in CNV pathogenesis and serve as potential biomarkers for CNV. | Jiancheng Huang Meng Chen Kai Xu Rongmei Zhou Shujie Zhang Chen Zhao | 2020 | The Journal of Biomedical Research2020，34，1： | 2 |
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