4篇
您的检索式：作者名="Liufang Gu"
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| 1 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 2 | Prediction and identification of HLA-A 0201-restricted epitopes from leukemia-associated protein MLAA-22 which elicit cytotoxic T lymphocytes 显示文摘 | JingLi Ju Bai Liufang Gu | 2014 | Med Oncol2014，，31： | 1 |
| 3 | Investigation of a novel biomarker, neuropilin-1, and its application for poor prognosis in acute myeloid leukemia patients显示文摘 | Jianqiang Zhao Liufang Gu Chengliang Li Weiguo Ma Zengfeng Ni | 2014 | Tumor Biology2014，，： | 1 |
| 4 | mRNA expression of the XAGE-1 gene in human acute leukemia显示文摘 | Yuqiang Ji Wanggang Zhang Jin Wang Liufang Gu | 2010 | International Journal of Hematology2010，，2： | 1 |
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