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| 1 | Study and Application of Polarographic Catalytic Wave of Chlordiazepoxide in the Presence of Persulfate显示文摘Polarographic catalytic wave of chlordiazepoxide in the presence of K2S2O8 was studied in aqueous and DMF/H2O mixed solutions,The results showed that a single reduction wave in alkaline medium was the reduction of the N=C bond in 1,2-position of chlordiazepoxide via an intermediate free radical in two one-electron successive additions,When K2S2O8 was present,the free radical of the N=C bond was oxidized to regenerate the original,producing a parallel catalytic wave of chlordiazepoxide,It was determined that the apparent rate constant kf of the oxidation reaction was 3.2×10^3 mol^-1.L.s^-1,Using the catalytic wave the trace of chlordiazepoxide can be determined by linear-potential scan polarography,In NH3/NH4Cl(pH 10.2±0.1,0.12mol/L)/K2S2O8(0.016mol/L)supporting electrolyte,the second-order derivative peak current of the catalytic wave was rectilinear to chlordiazepoxide concentration in the range of 3.20×10^-8-1.60×10^-7,1.60×10^-7-1.44×10^-6 and 1.44×10^-6-1.44×10^-5mol/L,respectively.The limit of detection was 9.0×10^-9mol/L. | Guo, W Lin, H Liu, LM Guo, ZA Song, JF | 2002 | Chinese Journal of Chemistry2002，20，5： | 3 |
| 2 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 3 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 4 | Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity显示文摘 | Cheng Q Aleksunes LM Manautou JE Cherrington NJ Scheffer GL Yamasaki H | 2008 | Mol Pharm2008，5，1： | 1 |
| 5 | Montelukast,a leukotriene receptor antagonist,for the treatment of persistent asthma in children aged 2 to 5 years显示文摘 | Knorr B Franchi LM Bisgaard H | 2001 | Pediatrics2001，108，3： | 1 |
| 6 | The Orthopedics Outcomes Study Group, A Longitudinal Study of Orthopedics Outcomes for severe factor FⅧ deficient hemophilia显示文摘 | Aledort LM Haschmeyer RH Pettersson H | 1994 | J intern Med Med1994，236，4： | 1 |
| 7 | European Polymer Journal显示文摘 | Tang EJ Liu H Sun LM | 2007 | (10):4 210-4 2182007，，10： | 1 |
| 8 | Maternal mortality in the United States: report from the matemal mortality collaborative 显示文摘 | Rochat R W Koofm LM Atrash H K | 1988 | Obstet Gynemol1988，72，1： | 1 |
| 9 | ER-alpha36, a novel vari- ant of ER-alpha, is expressed in ER-positive and -negative human breast carcinomas显示文摘 | Lee LM Cao J Deng H | 2008 | Anti cancer Res2008，1，： | 1 |
| 10 | Implications of a New Definition of Vitamin D Deficiency in a Multiracial US Adolescent Population: The National Health and Nutrition Examination Survey III 显示文摘 | Saintonge S Bang H Gerber LM | 2009 | Pediatriea2009，123，3： | 1 |
| 11 | ER-alpha36, a novel variant of ERalpha,is expressed in ER-positive and -negative human breastcarcinomas 显示文摘 | Lee LM Cao J Deng H | 2008 | Anticancer Res2008，28，1： | 1 |
| 12 | Molecular dynamics simulation of RGD peptide adsorption on titanium oxide surfaces显示文摘 | Zhang H P Lu X LM Fang | 2008 | J Mater Sci:Mater Med2008，19，： | 1 |
| 13 | Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease显示文摘 | Strauss KM Martins LM Plun-Favreau H | 2005 | Hum Mol Genet2005，14，15： | 1 |
| 14 | A novel adaptive beamforming algorithm for antenna array CDMA systems with strong interferers 显示文摘 | ChoiS Choi J Lm H | 2002 | IEEE Transactions on Vehicular Technology2002，51，5： | 1 |
| 15 | Acute myelogenous leukemia associated with extreme symptomatic thrombocytosis and chromosome 3q translocation: case report and review of literature显示文摘 | Chang VT Aviv H Howard LM | 2003 | Am J Hematol2003，72，： | 1 |
| 16 | Oxygen-mediated regulation ofgelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells显示文摘 | Canning MT Postovit LM Clarke H et aI | 2001 | Exp Cell Res2001，267，1： | 1 |
| 17 | On reference models for col- laborative networked organizations 显示文摘 | J Camarinha-Matos LM Afsarmanesh H | 2008 | Intemational Journal of Production Research2008，46，9： | 1 |
| 18 | The clinical observation of different dose sufentanil combined bupivacaine on spinal anesthesia in elderly patients显示文摘 | Pei H Zeng LM | 2012 | Chin J Postgraduates Med2012，35，： | 1 |
| 19 | Comparative analysis of a large dataset indicates that internal transcribed spacer(ITS)should be incorporated into the core barcode for seed plants显示文摘 | Li DZ Gao LM Li H Wang H Ge X J Liu JQ Chen ZD Zhou SL Chen SL Yang JB | | 0，，： | 1 |
| 20 | Cost-effective- ness of laparoseopic vs open resection for colon and rectal cancer 显示文摘 | Jensen CC Prasad LM Abcarian H | 2012 | Diseases of the colon and rectum2012，55，10： | 1 |
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