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| 1 | C - reactive protein is a risk for atrial fibrillation after myocardial revascular显示文摘 | Bernard LO Rob Fijnheer Arno P | 2005 | Ann Tho- rac Surg2005，79，： | 1 |
| 2 | Functional analysis of mosquito-borne flavivirus conserved sequence elements within 3'untranslated region of West Nile virus by use of a reporting replicon that differentiates between viral translation and RNA replication 显示文摘 | Lo MK Tilgner M Bernard KA | 2003 | J Virol2003，77，10： | 1 |
| 3 | Functional analysis of mosquito-borne flavivirus conserved sequence elements within 3'untranslated region of West Nile virus by use of a reporting replicon that differentiates between viral translation and RNA replication显示文摘 | Lo MK Tilgner M Bernard KA | 2003 | J Virol2003，77，10： | 1 |
| 4 | Comparative study of cone beam computed tomography and intraoral periapical radiographs in diagnosis of lingual-simulated external root resorptions 显示文摘 | Bernardes RA de Paulo RS Pereira LO | 2012 | Dent Traumatol2012，28，4： | 1 |
| 5 | Towards a consensus-based classification of childhood arterial ischemic stroke显示文摘 | Bernard TJ Manco-Johnson M J Lo W | | 0，，： | 1 |
| 6 | Conflict-of-Interest Policies for Investigators in Clinical Trials显示文摘 | Lo Bernard | 2000 | NEJM2000，343，22： | 1 |
| 7 | Functional analysis of mosquito-borne flavivirus conserved sequence elements within 3' untranslated region of West Nile virus by use of a reporting replicon that differentiates between viral translation and RNA replication显示文摘 | LO MK TILGNER M BERNARD KA | 2003 | J Virol2003，77，10： | 1 |
| 8 | Single high-dose erythropoietin administration immediately after reperfusion in patients with ST-segment elevation myocardial infarction: results of the Erythropoietin in Myocardial Infarction Trial显示文摘 | Fabrice Prunier Lo?c Bière Martine Gilard Jacques Boschat Frédéric Mouquet Jean-Jacques Bauchart Bernard Charbonnier Olivier Genée Patrice Guérin Karine Warin-Fresse Eric Durand Antoine Lafont Luc Christiaens Wissam Abi-Khalil Stéphane Delépine Thomas Ben | 2012 | American Heart Journal2012，，2： | 1 |
| 9 | Conflict-of-interest policies for investigators in clinical trials 显示文摘 | Bernard Lo Leslie Wolf Abiona Berkeley | 2000 | NEJM2000，343，22： | 1 |
| 10 | Allergy to bovine beta-lactoglobulin:specificity of human IgE to tryptic peptides显示文摘 | Sélo I Clément G Bernard H | | Clinical and Experimental Allergy0，，： | 1 |
| 11 | Confiled of interest policies for investigation in clinical trails显示文摘 | Bernard LO | 2000 | The New England Jounal of Medicine2000，343，6： | 1 |
| 12 | Moving interdisciplinary science forward:integrating participatory modelling with mathematical modelling of zoonotic disease in Africa显示文摘This review outlines the benefits of using multiple approaches to improve model design and facilitate multidisciplinary research into infectious diseases,as well as showing and proposing practical examples of effective integration.It looks particularly at the benefits of using participatory research in conjunction with traditional modelling methods to potentially improve disease research,control and management.Integrated approaches can lead to more realistic mathematical models which in turn can assist with making policy decisions that reduce disease and benefit local people.The emergence,risk,spread and control of diseases are affected by many complex bio-physical,environmental and socio-economic factors.These include climate and environmental change,land-use variation,changes in population and people’s behaviour.The evidence base for this scoping review comes from the work of a consortium,with the aim of integrating modelling approaches traditionally used in epidemiological,ecological and development research.A total of five examples of the impacts of participatory research on the choice of model structure are presented.Example 1 focused on using participatory research as a tool to structure a model.Example 2 looks at identifying the most relevant parameters of the system.Example 3 concentrates on identifying the most relevant regime of the system(e.g.,temporal stability or otherwise),Example 4 examines the feedbacks from mathematical models to guide participatory research and Example 5 goes beyond the so-far described two-way interplay between participatory and mathematical approaches to look at the integration of multiple methods and frameworks.This scoping review describes examples of best practice in the use of participatory methods,illustrating their potential to overcome disciplinary hurdles and promote multidisciplinary collaboration,with the aim of making models and their predictions more useful for decision-making and policy formulation. | Catherine Grant Giovanni Lo Iacono Vupenyu Dzingirai Bernard Bett Thomas R.A.Winnebah Peter M.Atkinson | 2016 | Infectious Diseases of Poverty2016，5，1： | 1 |
| 13 | Insights into the cellular trafficking of splice redirecting oligonucleotides complexed with chemically modified cell-penetrating peptides显示文摘 | Fatouma Said Hassane Rachida Abes Samir EL Andaloussi Taavi Lehto Rannar Sillard ülo Langel Bernard Lebleu | 2011 | Journal of Controlled Release2011，，2： | 1 |
| 14 | A machine learning model for colorectal liver metastasis post-hepatectomy prognostications显示文摘Background:Currently,surgical resection is the mainstay for colorectal liver metastases(CRLM)management and the only potentially curative treatment modality.Prognostication tools can support patient selection for surgical resection to maximize therapeutic benefit.This study aimed to develop a survival prediction model using machine learning based on a multicenter patient sample in Hong Kong.Methods:Patients who underwent hepatectomy for CRLM between 1 January 2009 and 31 December 2018 in four hospitals in Hong Kong were included in the study.Survival analysis was performed using Cox proportional hazards(CPH).A stepwise selection on Cox multivariable models with Least Absolute Shrinkage and Selection Operator(LASSO)regression was applied to a multiply-imputed dataset to build a prediction model.The model was validated in the validation set,and its performance was compared with that of Fong Clinical Risk Score(CRS)using concordance index.Results:A total of 572 patients were included with a median follow-up of 3.6 years.The full models for overall survival(OS)and recurrence-free survival(RFS)consist of the same 8 established and novel variables,namely colorectal cancer nodal stage,CRLM neoadjuvant treatment,Charlson Comorbidity Score,pre-hepatectomy bilirubin and carcinoembryonic antigen(CEA)levels,CRLM largest tumor diameter,extrahepatic metastasis detected on positron emission-tomography(PET)-scan as well as KRAS status.Our CRLM Machine-learning Algorithm Prognostication model(CMAP)demonstrated better ability to predict OS(C-index=0.651),compared with the Fong CRS for 1-year(C-index=0.571)and 5-year OS(C-index=0.574).It also achieved a C-index of 0.651 for RFS.Conclusions:We present a promising machine learning algorithm to individualize prognostications for patients following resection of CRLM with good discriminative ability. | Cynthia Sin Nga Lam Alina Ashok Bharwani Evelyn Hui Yi Chan Vernice Hui Yan Chan Howard Lai Ho Au Margaret Kay Ho Shireen Rashed Bernard Ming Hong Kwong Wentao Fang Ka Wing Ma Chung Mau Lo Tan To Cheung | 2023 | Hepatobiliary Surgery and Nutrition2023，12，4： | 0 |
| 15 | Genome-wide association mapping in a sweet cherry germplasm collection(Prunus avium L.)reveals candidate genes for fruit quality traits显示文摘In sweet cherry(Prunus avium L.),large variability exists for various traits related to fruit quality.There is a need to discover the genetic architecture of these traits in order to enhance the efficiency of breeding strategies for consumer and producer demands.With this objective,a germplasm collection consisting of 116 sweet cherry accessions was evaluated for 23 agronomic fruit quality traits over 2-6 years,and characterized using a genotyping-by-sequencing approach.The SNP coverage collected was used to conduct a genome-wide association study using two multilocus models and three reference genomes.We identified numerous SNP-trait associations for global fruit size(weight,width,and thickness),fruit cracking,fruit firmness,and stone size,and we pinpointed several candidate genes involved in phytohormone,calcium,and cell wall metabolisms.Finally,we conducted a precise literature review focusing on the genetic architecture of fruit quality traits in sweet cherry to compare our results with potential colocalizations of marker-trait associations.This study brings new knowledge of the genetic control of important agronomic traits related to fruit quality,and to the development of marker-assisted selection strategies targeted towards the facilitation of breeding efforts. | Armel S.L.Donkpegan Anthony Bernard Teresa Barreneche José Quero-García Hélène Bonnet Mathieu Fouché Loïck Le Dantec Bénédicte Wenden Elisabeth Dirlewanger | 2023 | Horticulture Research2023，10，10： | 0 |
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