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| 1 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 2 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 3 | Isolation and characterization of polymorphic microsatellites from red coral grouper(Plectropomus maculatus)显示文摘 | Zhu Z Y Lo L C Lin G | 2005 | Molecular Ecology Notes2005，5，3： | 1 |
| 4 | Novel baculovirus DNA elements strongly stimulate activities of exogenous and endogenous promoters 显示文摘 | LO H R CHOU C C WU T Y | 2002 | The Journal of Biological Chemistry2002，277，7： | 1 |
| 5 | Ethyl caffeate suppresses NF-kappa B activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin显示文摘 | Chiang Y M Lo C P Chen Y P | 2005 | Br J Pharmacol2005，146，3： | 1 |
| 6 | High-performance capillary electrophoretic method for the determination of antiobiotic fungicide kasugamycin in formulated products 显示文摘 | LO C C HSIAO Y M | 1996 | J Agric Food Chem1996，44，80： | 1 |
| 7 | Teratoma in the region of adre- nal glanda unique entity masquerading as lipomatous adrenal tumor显示文摘 | LAM K Y LO C Y | 1999 | Surgery1999，126，： | 1 |
| 8 | Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange(Citrus sinensis) peel显示文摘 | Li S Lo C Y Ho C T | 2006 | Journal of Agriculture Food Chemistry2006，54，： | 1 |
| 9 | Reassessing the joint roughness coefficient (JRC) estimation using Z2显示文摘 | YANG Z Y LO S C DI C C | 2011 | Rock Mechanics and Rock Engineering2011，34，3： | 1 |
| 10 | Higher complication risk of totally implantable venous access port systems in patients with advanced cancer:A single institution retro-spective analysis 显示文摘 | Chang Y F Lo A C Tsai C H | 2013 | Palliat Med2013，27，2： | 1 |
| 11 | Realtime curve interpolators显示文摘 | SHPITALNI M KOREN Y LO C C | 1994 | Computer-Aided Design1994，26，11： | 1 |
| 12 | Colchicine-induced amphiploids from cell culture of Saccharum-Miscanthus hybrids显示文摘 | Chen Y H Lo C C Chen C | 1992 | Report of the Taiwan Sugar Research Institute1992，136，： | 1 |
| 13 | Diaehronous uplift of the Tibetan Plateau starting 40 Myr ago显示文摘 | Chung S L Lo C H Lee T Y | 1998 | Nature1998，394，： | 1 |
| 14 | Realtime curve interpola- tors显示文摘 | Shpitalni M Koren Y Lo C C | 1994 | Computer-Aided Design1994，26，11： | 1 |
| 15 | Microwave-hydrothermal decomposition of perfluorooctanoic acid in water by iron-activated persulfate oxidation显示文摘 | Lee Y C Lo S L Chiueh P T | | Water Research0，44，3： | 1 |
| 16 | Real-time Curve In- terpolation 显示文摘 | SHIPITALNI M KOREN Y LO C C | 1994 | Computer-Aided Design1994，26，11： | 1 |
| 17 | Impact of supplement with Lacto- bacitlus and Bifidobacterium-eontaining yogurt on triple therapy for He- licobacter pylori eradication 显示文摘 | SHEU B S WU J J LO C Y | 2002 | Ailment Pharmacol Ther2002，16，： | 1 |
| 18 | Smooth sliding mode control for spacecraft attitude tracking maneuvers显示文摘 | Lo S C Chen Y P | 1995 | Journal of Guidance Control and Dynamics1995，18，6： | 1 |
| 19 | Hypoxia-induced oxidative stress in ischemic retinopathy显示文摘 | Li S Y Fu Z J Lo A C | 2012 | Oxid Med Cell Longev2012，2012，42： | 1 |
| 20 | Reliability assessment and sensitivity analysis of software reliability growth modeling based on software module structure显示文摘 | LO J H HUANG C Y CHEN I Y | | 0，，01： | 1 |
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