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| 1 | Role of the receptor for advanced glycation end products in hepatic fibrosis显示文摘AIM:To study the role of advanced glycation end products(AGE)and their specifi c receptor(RAGE)in the pathogenesis of liver fi brogenesis.METHODS:In vitro RAGE expression and extracellular matrix-related gene expression in both rat and human hepatic stellate cells(HSC)were measured after stimulation with the two RAGE ligands,advanced glycation end product-bovine serum albumin(AGE-BSA)and Nε-(carboxymethyl)lysine(CML)-BSA,or with tumor necrosis factor-α(TNF-α).In vivo RAGE expression was examined in models of hepatic fi brosis induced by bile duct ligation or thioacetamide.The effects of AGE-BSA and CML-BSA on HSC proliferation,signal transduction and profi brogenic gene expression were studied in vitro.RESULTS:In hepatic fibrosis,RAGE expression was enhanced in activated HSC,and also in endothelial cells,inflammatory cells and activated bile duct epithelia.HSC expressed RAGE which was upregulated after stimulation with AGE-BSA,CML-BSA,and TNF-α.RAGE stimulation with AGE-BSA and CML-BSA did not alter HSC proliferation,apoptosis,fibrogenic signal transduction and fibrosis-or fibrolysis-related gene expression,except for marginal upregulation of procollagen α1(Ⅰ)mRNA by AGE-BSA.CONCLUSION:Despite upregulation of RAGE in activated HSC,RAGE stimulation by AGE does not alter their fibrogenic activation.Therefore,RAGE does not contribute directly to hepatic fibrogenesis. | Christina Lohwasser Daniel Neureiter Yury Popov Michael Bauer Detlef Schuppan | 2009 | World Journal of Gastroenterology2009，15，46： | 13 |
| 2 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 3 | Raumforderung im vorderen Mediastinum bei einer Patientin mit Morbus Basedow und einem Osteosarkom in der Vorgeschichte显示文摘 | Lohwasser S Wagner HM Arndt H | 1997 | Deutsche Medizinische Wochenschrift1997，122，36： | 1 |
| 4 | Economics of CCS for coal plants: Impact of investment costs and efficiency on market diffusion in Europe显示文摘 | Lohwasser R Madlener R | 2012 | Energy Economics2012，34，3： | 1 |
| 5 | The receptorfor advanced glycation end products is highly expressed inthe skin and upregulated by advanced glycation end prod-ucts and tumor necrosis factor-alpha显示文摘 | Lohwasser C Neureiter D Weigle B | 2006 | J Invest Derma-tol2006，126，2： | 1 |
| 6 | Phase separation in the melt and confined crystallization as the key to well-ordered microphase separated donor-acceptor block copolymers显示文摘 | Lohwasser R H Gupta G Kohn P | 2013 | Macromolecules2013，46，11： | 1 |
| 7 | Monte Carlo simulations and laser doppler flow measurements with high penetration depth in biological tissuelike head phantoms显示文摘 | SOELKNER G MITIC G LOHWASSER R | 1997 | Appl Opt1997，36，： | 1 |
| 8 | Molecular mapping of genomic regions associated with wheat seedling growth under osmotic stress显示文摘 | LANDJEVA S NEUMANN K LOHWASSER U BORNER A | 2008 | Biologia Plantarum2008，52，2： | 1 |
| 9 | IFN-gamma production and cytotoxicity of IL-2-activated murine NK cells are differentially regulated by MHC class Ⅰ molecules 显示文摘 | Kubota A Lian R H Lohwasser S | 1999 | J Immunol1999，163，12： | 1 |
| 10 | Molecular mapping of genomic regions associated with wheat seedling growth under osmotic stress显示文摘 | Landjeva S Neumaml K Lohwasser U | 2008 | Biologia Plantarum2008，52，2： | 1 |
| 11 | Discovery of loci deter- mining pre-harvest sprouting and dormancy in wheat and bar- ley applying segregation and association mapping 显示文摘 | LOHWASSER U ARIF BORNER A | 2013 | Biologia Plantarum2013，57，4： | 1 |
| 12 | Genetic mapping within the wheat D genome reveals QTL for germination, seed vigour and longevity, and early seedling growth显示文摘 | S. Landjeva U. Lohwasser A. B?rner | 2010 | Euphytica2010，，1： | 1 |
| 13 | The receptor for advanced glycation end products is highly expressed in the skin and upregulated by advanced glycation end products and tumor necrosis factor-alpha显示文摘 | Lohwasser C Neureiter D Weigle B | | 0，，02： | 1 |
| 14 | IFN-gamma production and cytotoxicity of IL-2-activated murine NK cells are differentially regulated by MHC class Ⅰ molecules 显示文摘 | Kubota A Lian RH Lohwasser S | 1999 | J Immunol1999，163，12： | 1 |
| 15 | Molecular mapping of genes determining hairy leaf character in common wheat with respect to other species of the Triticeae显示文摘 | O. Dobrovolskaya T. A. Pshenichnikova V. S. Arbuzova U. Lohwasser M. S. R?der A. B?rner | 2007 | Euphytica2007，，3： | 1 |
| 16 | Genetic mapping within the wheat D genome reveals QTL for germination, seed vigor and lon- gevity, and early seedling growth显示文摘 | Landjeva S Lohwasser U Borner A | 2010 | Euphytica2010，171，： | 1 |
| 17 | Role of the receptor for ad- vanced glycation end product in hepatic fibrosis显示文摘 | Lohwasser C Neureiter D Popov Y | 2009 | World J Gastroen- tero12009，15，： | 1 |
| 18 | Economics of CCS for Coal Plants: Impact of Invcstnaent Costs and Efficiency on Market Dif- fusion in Europe 显示文摘 | Lohwasser R Madlener R | 2012 | Energy Economics2012，34，3： | 1 |
| 19 | The receptor for advanced glycation end products is highly expressed in the skin andupregulated by advanced glycation end products and tumor necrosisfactor-alpha 显示文摘 | Lohwasser C Neureiter D Weigle B | 2006 | J Invest Dermato2006，126，2： | 1 |
| 20 | Orderly and nonstochastic acquisition of CD94/NKG2 receptors by developing NK cells derived from embryonic stem cells in vitro显示文摘 | Lian RH Maeda M Lohwasser S | | 0，，： | 1 |
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