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| 1 | The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation显示文摘Interleukin(IL)17-producing T helper(Th17)cells play critical roles in the clearance of extracellular bacteria and fungi as well as the pathogenesis of various autoimmune diseases,such as multiple sclerosis,psoriasis,and ulcerative colitis.Although a global transcriptional regulatory network of Th17 cell differentiation has been mapped recently,the participation of epigenetic modifications in the differentiation process has yet to be elucidated.We demonstrated here that histone H3 lysine-27(H3K27)demethylation,predominantly mediated by the H3K27 demethylase Jmjd3,crucially regulated Th17 cell differentiation.Activation of naı¨ve CD41 T cells immediately induced high expression of Jmjd3.Genetic depletion of Jmjd3 in CD41 T cells specifically impaired Th17 cell differentiation both in vitro and in vivo.Ectopic expression of Jmjd3 largely rescued the impaired differentiation of Th17 cells in vitro in Jmjd3-deficientCD41 T cells.Importantly,Jmjd3-deficient mice were resistant to the induction of experimental autoimmune encephalomyelitis(EAE).Furthermore,inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppressed Th17 cell differentiation in vitro.At the molecular level,Jmjd3 directly bound to and reduced the level of H3K27 trimethylation(me3)at the genomic sites ofRorc,which encodes the masterTh17 transcription factorRorgt,and Th17 cytokine genes such as Il17,Il17f,and Il22.Therefore,our studies established acritical role of Jmjd3-mediatedH3K27demethylation inTh17 cell differentiation andsuggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses. | Zhi Liu Wei Cao Longxia Xu Xi Chen Yu Zhan Qian Yang Sanhong Liu Pengfei Chen Yuhang Jiang Xiaohua Sun Yu Tao Yiming Hu Cuifeng Li Qi Wang Ying Wang Charlie Degui Chen Yufang Shi Xiaoren Zhang | 2015 | Journal of Molecular Cell Biology2015，7，6： | 6 |
| 2 | Uncertainty analysis of hydrological processes based on ARMA-GARCH model显示文摘Uncertainty analysis and risk analysis are two important areas of modern water resource management,in which accurate variance estimation is required.The traditional runoff model is established under the assumption that the variance is a constant or it changes with the seasons.However,hydrological processes in the real world are often heteroscedastic,which can be tested by McLeod-Li test and Engle Lagrange multiplier test.In such cases,the GARCH model of hydrological processes is established in this article.First,the seasonal factors in the sequence are removed.Second,the traditional ARMA model is established.Then,the GARCH model is used to correct the residual.At last,the daily runoff data in 1949-2001 of Yichang Hydrological Station is taken to be an example.The result shows that compared to the traditional ARMA model,the GARCH model has the ability to predict more accurate confidence intervals under the same confidence level. | WANG HongRui GAO Xiong QIAN LongXia YU Song | 2012 | Science China(Technological Sciences)2012，55，8： | 6 |
| 3 | Study of a new one-way timing method显示文摘This paper combines the advantages of both common-view time transfer and one-way timing and proposes a new one-way timing method.Owing to the limitations in users capacity and real-time,common-view time transfer can not provide time service simultaneously for mass users.A zero baseline experiment is carried out to validate its feasibility.Experimental results indicate this new method can achieve a timing accuracy within 5 ns.Users with requirements of rigorous time can employ this method to keep time synchronized with timing labs. | XU LongXia LI XiaoHui XUE YanRong CAI ChengLin GUO MeiJun | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 3 |
| 4 | Certificateless Public Verification for Data Storage and Sharing in the Cloud显示文摘By advances in cloud computing,users are allowed to remotely store their data in the cloud,manage the stored data without limitation of time and place,and give rights to visitors that want to access to their data.As may no longer possess data physically,the data owner has to ensure the integrity of the data with the public key given by Public key infrastructure(PKI).However,there are many security risks of the traditional PKI and the certificate management is complex.We utilize elliptic curve group to propose a certificateless signature to solve the above problem.To check the integrity of files stored in the cloud,we design a certificateless public verification mechanism based on the signature and further extend it to support batch auditing tasks.Meanwhile,an efficient key updating method is proposed to provide visitors a friendly data success environment.The security analysis proves that the proposed scheme is secure under the discrete logarithm assumption.Extensive theoretical analyses and experimental results show the effectiveness of the proposed scheme. | HUANG Longxia ZHOU Junlong ZHANG Gongxuan ZHANG Mingyue | 2020 | Chinese Journal of Electronics2020，29，4： | 3 |
| 5 | CExp: secure and verifiable outsourcing of composite modular exponentiation with single untrusted server显示文摘 | Shuai Li Longxia Huang Anmin Fu John Yearwood | 2017 | Digital Communications and Networks2017，3，4： | 2 |
| 6 | Safety and efficacy of US-guided high-intensity focused ultrasound for treatment of submucosal fibroids显示文摘 | Wei Wang Yang Wang Ting Wang Junyan Wang Longxia Wang Jie Tang | 2012 | European Radiology2012，，11： | 1 |
| 7 | Nitrogen-doping of Chemically Reduced Mesocarbon Microbead Oxide for the Improved Performance of Lithiumion Batteries显示文摘 | Han Pengxian Yue Yanhua Zhang Longxia | 2012 | Carbon2012，50，3： | 1 |
| 8 | On the existence of periodic solutions to a fonrth-order p-Laplacian differential equation with a deviating argument 显示文摘 | WANG Zhengxin QIAN Longxia LU Shiping | 2010 | Nonlinear Analysis:Real World Ap- plications2010，11，： | 1 |
| 9 | The existence and uniqueness of periodic solutions for a kind of Duigmg - type equation with two deviating arguments显示文摘 | Wang Zhengxin Qian Longxia Lu Shiping etal | 2010 | Nonlinear Analysis2010，73，： | 1 |
| 10 | The existence and uniqueness of periodic solutions for a kind of Duffing-type equation with two deviating arguments 显示文摘 | Wang Zhengxin Qian Longxia Lu Shiping | 2010 | Nonlinear Anal2010，73，9： | 1 |
| 11 | Ultrasound-guided high-intensity focused ultrasound treatment for abdominal wall endometriosis: Preliminary results显示文摘 | Yang Wang Wei Wang Longxia Wang Junyan Wang Jie Tang | 2010 | European Journal of Radiology2010，，1： | 1 |
| 12 | JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice显示文摘JMJD3(KDM6B)is an H3K27me3 demethylase and counteracts polycomb-mediated transcription repression.However,the function of JMJD3 in vivo is not well understood.Here we show that JMJD3 is highly expressed in cells of the chondrocyte lineage,especially in prehypertrophic and hypertrophic chondrocytes,during endochondral ossification.Homozygous deletion of Jmjd3 results in severely decreased proliferation and delayed hypertrophy of chondrocytes,and thereby marked retardation of endochondral ossification in mice.Genetically,JMJD3 associates with RUNX2 to promote proliferation and hypertrophy of chondrocytes.Biochemically,JMJD3 associates with and enhances RUNX2 activity by derepression of Runx2 and Ihh transcription throughits H3K27me3 demethylase activity.These results demonstrate that JMJD3 is a key epigenetic regulator in the process of cartilage maturation during endochondral bone formation. | Feng Zhang Longyong Xu Longxia Xu Qing Xu Dangsheng Li Yingzi Yang Gerard Karsenty Charlie Degui Chen | 2015 | Journal of Molecular Cell Biology2015，7，1： | 0 |
| 13 | K-Means Clustering with Local Distance Privacy显示文摘With the development of information technology,a mass of data are generated every day.Collecting and analysing these data help service providers improve their services and gain an advantage in the fierce market competition.K-means clustering has been widely used for cluster analysis in real life.However,these analyses are based on users’data,which disclose users’privacy.Local differential privacy has attracted lots of attention recently due to its strong privacy guarantee and has been applied for clustering analysis.However,existing K-means clustering methods with local differential privacy protection cannot get an ideal clustering result due to the large amount of noise introduced to the whole dataset to ensure the privacy guarantee.To solve this problem,we propose a novel method that provides local distance privacy for users who participate in the clustering analysis.Instead of making the users’records in-distinguish from each other in high-dimensional space,we map the user’s record into a one-dimensional distance space and make the records in such a distance space not be distinguished from each other.To be specific,we generate a noisy distance first and then synthesize the high-dimensional data record.We propose a Bounded Laplace Method(BLM)and a Cluster Indistinguishable Method(CIM)to sample such a noisy distance,which satisfies the local differential privacy guarantee and local dE-privacy guarantee,respectively.Furthermore,we introduce a way to generate synthetic data records in high-dimensional space.Our experimental evaluation results show that our methods outperform the traditional methods significantly. | Mengmeng Yang Longxia Huang Chenghua Tang | 2023 | Big Data Mining and Analytics2023，6，4： | 0 |
| 14 | Ecological compensation mechanism for urban green land and its application in Shanghai, China显示文摘Urban green land compensation plays an impor-tant role in county development,ecological environment management and many other fields.The concept,methods and principles of urban green land are introduced in this paper.According to the pay fee method,the value and ecological function of various types of urban green land were analyzed.The cost-benefit analysis method(CBAM)was used to estimate different external diseconomy benefits caused by green land loss.The authors applied CBAM to estimate such benefits in the case of Shanghai,China,and calculated the actual compensation value for green land.Results indicated that in 2002,the compensation value for the green land of Shanghai was RMB 8.58×10^(5) Yuan/hm^(2). | WANG Yan DING Xiaowen QIAN Longxia WANG Hongrui | 2007 | Frontiers of Environmental Science & Engineering2007，1，3： | 0 |
| 15 | Electrophysiological Characteristics and Radiofrequency Ablation of the Focal Atrial Fibrillation Originating From the Superior Vena Cava(摘要)显示文摘Introduction: The superior vena cava (SVC) has cardiac musculature extending from the right atrium and could be one potential origin of focal atrial fibrillation (AF). Paroxysmal AF originated from the SVC was identified in three patients. Methods and Results: It consisted of 2 female aged 55, 58 and 60 years respectively. Two of them had brady-tachy syndrome and a pacemaker implantation. Daily paroxysmal palpitation due to paroxysmal AF and runs of atrial tachycardia initiated by atrial ectopic beats was observed through 12 leads ECG and Holter recordings in all patients. The morphology of P` wave was positive with a high amplitude in leads II, III, aVF, and negative in aVR. The SVC was mapped with a circumferential 10-electrode catheter. The atrial electrogram was preceded by SVC muscular potential (spike-like) during the ectopic activity and a temporal reversal was exhibited during sinus rhythm. Spontaneous AF initiated by a burst of rapid ectopic beats from the SVC was consistently observed. Ostial radiofrequency ablation was performed at segments characterized by fusion of the atrial electrogram and the SVC muscular potential and SVC electrical disconnection was achieved. During 12, 9 and 1 months’ follow-up, all patients were free from recurrences of AF despite difficult arrhythmia control pre-procedure.Conclusion:Focal AF may originate from SVC with a characteristic morphology of P` wave. Some of the paroxysmal AF associated with brady-tachy syndrome may also have a focal origin. | SHAO Wenliu, YUN Longxia, YANG Zongyang, et al. Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China. | 2002 | 海南医学2002，13，12： | 0 |
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