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| 1 | MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus显示文摘AIM To investigate the micro RNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.METHODS High throughput screening using Taq Man~ Array Human Micro RNA quantitative PCR was used to determine expression levels of 754 micro RNAs in distal esophageal mucosa(1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett's esophagus using argon plasma coagulation vs pretreatment mucosa, posttreatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett's esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted m RNA target pathway analysis was used to investigate the functional involvement of differentially expressed micro RNAs.RESULTS Forty-four micro RNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen micro RNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine micro RNAs(mi R-424-5p, mi R-127-3p, mi R-98-5p, mi R-187-3p, mi R-495-3p, mi R-34c-5p, mi R-223-5p, mi R-539-5p, mi R-376a-3p, mi R-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These micro RNAs were also more highly expressed in Barrett's esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in the regulation of cell survival signalling pathways. Three micro RNAs(mi R-187-3p, mi R-135b-5p and mi R-31-5p) were expressed at higher levels in postablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These mi RNAs were expressed at similar levels in preablation Barrett's esophagus mucosa, matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in regulating the expression of proteins that contribute to barrier function.CONCLUSION Neosquamous mucosa arising after ablation of Barrett's esophagus expresses micro RNAs that may contribute to decreased barrier function and micro RNAs that may be involved in the regulation of survival signaling pathways. | Loveena Sreedharan George C Mayne David I Watson Timothy Bright Reginald V Lord Alfiya Ansar Tingting Wang Jakob Kist David StJ Astill Damian J Hussey | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 2 | Improved recoverability of microbial colonies from marine sponge samples显示文摘 | Olson J B Lord C C McCarthy P J | 2000 | Microbial Ecology2000，40，： | 1 |
| 3 | Finite element modeling of magnetic field/defect interactions 显示文摘 | Hwang J H Lord W | 1975 | Journal of Testing & Evaluation (S0090-3973)1975，3，1： | 1 |
| 4 | Percutaneous sclerotherapy for lymphatic malformations:a retrospective analysis of patient-evaluated improvement显示文摘 | Alomari A I Karian V E Lord D J | 2006 | J Vasc Interv Radiol2006，17，10： | 1 |
| 5 | The DNA damage response and cancer therapy显示文摘 | Lord C J Ashworth A | | 0，，： | 1 |
| 6 | Identity, deep structure and the development of leadership skill 显示文摘 | Robert G Lord T Hall R J | 2005 | The Leadership Quarterly2005，16，： | 1 |
| 7 | Dynamic characteristics of a base isolated building from ambient vibration measurements and low level earthquake shaking 显示文摘 | Ventura C E Liam F W D Lord J F | 2003 | Soil Dynamics and Earthquake Engineering2003，23，4： | 1 |
| 8 | NLK is a novel therapeutic target for PTEN deficient tumour cells显示文摘 | Mendes-Pereira A M Lord C J Ashworth A | 2012 | PLoS One2012，7，47： | 1 |
| 9 | Evaluation of quantitative PCR reference genes for gene expression studies in Tribolium castaneum after fungal challenge显示文摘 | Lord J C Hartzer K Toutges M | | 0，，02： | 1 |
| 10 | Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small-cell lung cancer显示文摘 | Lord RV Brabender J Gandara D | 2002 | Clin Cancer Res2002，，8： | 1 |
| 11 | Increased phosphorylation of a 26-kD pollen protein is induced by the self-incompatibility response in Papaver rhoeas显示文摘 | RUDD J FRANKLIN F LORD J | 1996 | The Plant Cell1996，8，： | 1 |
| 12 | Leptin prevents the fall in plasma osteocalcin during starvation in male mice显示文摘 | Goldstone A P Howard J K Lord G M | 2002 | Biochem Biophys Res Commun2002，295，2： | 1 |
| 13 | Applications of solid-phase microextraction in food analysis显示文摘 | Kataoka H Lord H L Pawliszyn J | 2000 | Journal of Chromatography A2000，880，1： | 1 |
| 14 | Chest tube complications:how well are we training our residents?显示文摘 | Ball CG Lord J Laupland KB | 2007 | Can J Surg2007，50，6： | 1 |
| 15 | Dynamic characteristics of a base isolated building from ambient vibration measurements and low level earthquake shaking显示文摘 | Ventura C E Liam Finn W D Lord J F | 2003 | Soil Dynamics and Earthquake Engineering2003，23，： | 1 |
| 16 | Modulation of peroxisome proliferator-activated re-ceptor delta and gamma transcripts in swine endome-trial tissue during early gestation显示文摘 | LORD E MURPHY B D DESMARAIS J A | 2006 | Reproduction2006，131，5： | 1 |
| 17 | Utilizing RNA interference to enhance cancer drug discovery显示文摘 | Iorns E Lord C J Turner N | 2007 | Nat Rev Drug Discov2007，6，7： | 1 |
| 18 | Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small-cell lung cancer显示文摘 | Lord RVN Brabender J Gandara D | | 0，，07： | 1 |
| 19 | A photoactivatable push-pull fluorophore for single-molecule imaging in live cells显示文摘 | Lord S J Conley N R Lee H L D Samuel R Liu N Twieg R J Moerner W E | | 0，，29： | 1 |
| 20 | The gona- dotrophin-releasing hormone receptor maps to sheep chro- mosome 6 outside of the region of the FecB locus 显示文摘 | Montgomery G W Penty J M Lord E A | 1995 | Mammalian Genome: Official Journal of the International Mammalian Genome Society1995，6，6： | 1 |
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