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| 1 | Breast cancer in China显示文摘 | Lei Fan Kathrin Strasser-Weippl Jun-Jie Li Jessica St Louis Dianne M Finkelstein Ke-Da Yu Wan-Qing Chen Zhi-Ming Shao Paul E Goss | 2014 | Lancet Oncology2014，，7： | 4 |
| 2 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 3 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 4 | Early postnatal food intake alters myofiber maturation in pig skeletal muscle1显示文摘 | LOUIS L PATRICK E YVES M B | 2003 | The Journal of Nutrition2003，133，1： | 1 |
| 5 | Molecular phylogenetics of Squamata: the position of snakes, amphisbaenians, and dibamids, and the root of the squamate tree显示文摘 | Townsend T M Larson A Louis E | 2004 | Systematic Biology2004，53，5： | 1 |
| 6 | Malignant hyperthermia and porcine stress syndrome: a tale of two species 显示文摘 | Louis C F Gallant E M Remple E | 1990 | Pig News and Information1990，11，3： | 1 |
| 7 | Tumour necrosis factor (TNF) gene polymorphism in Crohn's disease (CD):influence on disease behaviour显示文摘 | Louis E Peeters M Franchimont D | 2000 | Clin Exp Immunol2000，119，1： | 1 |
| 8 | Recent Advances in Synchronous-Clock One-Way-Travel-Time Acoustic Navigation显示文摘 | Ryan M E Louis LW | | 0，，： | 1 |
| 9 | Thermal expansion behaviour of aluminum/SiC composites with bimodal particle distributions显示文摘 | Arpon R Molina J M Saravanan R A Garcia-Cordovilla C Louis E Narciso J | 2003 | Acta Mater2003，51，11： | 1 |
| 10 | The association of incident dementia with mortality in PD显示文摘 | LEVY G TANG M X LOUIS E D | 2002 | Neurology2002，59，11： | 1 |
| 11 | Synthesis of highly conducting films of derivatives of polyacetylene, (CH)x 显示文摘 | Chiang C K Louis E J Druy M A | 1978 | J Am Chem Soc1978，100，： | 1 |
| 12 | 显示文摘 | Liu C Dubois K D Louis M E | 2013 | ACS Catalysis2013，3，4： | 1 |
| 13 | Molecular phylogeneties of Squamata : the position of snakes, am- phisbaenians ,and dibamids ,and the root of the squamate tree显示文摘 | TOWNSEND T M LARSON A LOUIS E | 2004 | Systematic Biology2004，53，5： | 1 |
| 14 | A review of dendritic hyperbranehed polymer as modifiers in epoxy eomposites 显示文摘 | Raffaele M Louis B Jan - Anders E M | 2001 | Composites Science and Techology2001，61，： | 1 |
| 15 | Reactivity and thermal behaviour of Cu-Si/SiC composites : effects of SiC oxidation 显示文摘 | Narciso J Weber L Molina J M Mortensen A Louis E | 2005 | Material Science and Technology2005，22，12： | 1 |
| 16 | Effects of landscape structure on nest predation in roadsides of a midwestern agroecosystem: A multiscale analysis显示文摘 | Timothy M B Louis B B Kathryn E F | 2000 | Landscape Ecology2000，15，： | 1 |
| 17 | HIV prevalence in patientswith syphilis,United States显示文摘 | Blocker M E Levine W C St Louis M E | 2000 | Sex Transm Dis2000，27，1： | 1 |
| 18 | Epidermal growth factor receptor and Ink4a/Arf显示文摘 | Robert M Bachoo Elizabeth A Maher Keith L Ligon Norman E Sharpless Suzanne S Chan Mingjian James You Yi Tang Jessica DeFrances Elizabeth Stover Ralph Weissleder David H Rowitch David N Louis Ronald A DePinho | 2002 | Cancer Cell2002，，3： | 1 |
| 19 | Entrepreneurs in academe: An exploration of behaviors among life scientists显示文摘 | Louis K S Blumenthal D Gluck M E | 1989 | Administrative Science Quarterly1989，34，： | 1 |
| 20 | Synthesis and luminescent properties of sub-5-nm lanthanide oxides nanoparticles显示文摘 | Bazzi R Flores-Gonzalez M A Louis C Lebbou K Dujardin C Brenier A Zhang W Tillement O Bernstein E Perriat P | | 0，，0： | 1 |
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