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1篇 您的检索式:作者名="Louis Mercado"
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1Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid显示文摘Bacterial infections have become a global issue that requires urgent attention,particularly regarding to emergence of multidrug resistant bacteria.We developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in the main-chain.Interestingly,by choosing appropriate monomers,these cationic polymers can form core-shell micelles.These polymers exhibited biocidal activity against both Gram-positive and Gram-negative bacterial species.It is demonstrated that the micelles can deliver hydrophobic antibiotics that functionally have dual antimicrobial activities.Cytotoxicity assays against HeLa cells showed dosage-dependent toxicity for polymers with longer linkers.Mitra S.Ganewatta Md Anisur Rahman Louis Mercado Tinom Shokfai Alan W.Decho Theresa M.Reineke Chuanbing Tang 2018Bioactive Materials2018,3,2:1
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