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您的检索式：作者名="Alan W.Decho"
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| 1 | Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid显示文摘Bacterial infections have become a global issue that requires urgent attention,particularly regarding to emergence of multidrug resistant bacteria.We developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in the main-chain.Interestingly,by choosing appropriate monomers,these cationic polymers can form core-shell micelles.These polymers exhibited biocidal activity against both Gram-positive and Gram-negative bacterial species.It is demonstrated that the micelles can deliver hydrophobic antibiotics that functionally have dual antimicrobial activities.Cytotoxicity assays against HeLa cells showed dosage-dependent toxicity for polymers with longer linkers. | Mitra S.Ganewatta Md Anisur Rahman Louis Mercado Tinom Shokfai Alan W.Decho Theresa M.Reineke Chuanbing Tang | 2018 | Bioactive Materials2018，3，2： | 1 |
| 2 | Facial amphiphilicity index correlating chemical structures with antimicrobial efficacy显示文摘Facial amphiphilicity is an extraordinary chemical structure feature of a variety of antimicrobial peptides and polymers.Vast efforts have been dedicated to small molecular,macromolecular and dendrimer-like systems to mimic this highly preferred structure or conformation,including local facial amphiphilicity and global amphiphilicity.This work conceptualizes Facial Amphiphilicity Index(FAI)as a numerical value to quantitatively characterize the measure of chemical compositions and structural features in dictating antimicrobial efficacy.FAI is a ratio of numbers of charges to rings,representing both compositions of hydrophilicity and hydrophobicity.Cationic derivatives of multicyclic compounds were evaluated as model systems for testing antimicrobial selectivity against Gram-negative and Gram-positive bacteria.Both monocyclic and bicyclic compounds are non-antimicrobial regardless of FAIs.Antimicrobial efficacy was observed with systems having larger cross-sectional areas including tricyclic abietic acid and tetracyclic bile acid.While low and high FAIs respectively lead to higher and lower antimicrobial efficacy,in consideration of cytotoxicity,the sweet spot is typically suited with intermediate FAIs for each specific system.This can be well explained by the synergistic hydrophobic-hydrophobic and electrostatic interactions with bacterial cell membranes and the difference between bacterial and mammalian cell membranes.The adoption of FAI would pave a new avenue toward the design of next-generation antimicrobial macromolecules and peptides. | Leman Buzoglu Kurnaz Yuanyuan Luo Xiaoming Yang Amjed Alabresm Ryan Leighton Rani Kumar JiHyeon Hwang Alan W.Decho Prakash Nagarkatti Mitzi Nagarkatti Chuanbing Tang | 2023 | Bioactive Materials2023，，2： | 0 |
| 3 | Antifouling and antimicrobial cobaltocenium-containing metallopolymer double-network hydrogels显示文摘Compared with single-network hydrogels,double-network hydrogels offer higher mechanical strength and toughness.Integrating useful functions into double-network hydrogels can expand the portfolios of the hydrogels.We report the preparation of double-network metallopolymer hydrogels with remarkable hydration,antifouling,and antimicrobial properties.These cationic hydrogels are composed of a first network of cationic cobaltocenium polyelectrolytes and a second network of polyacrylamide,all prepared via radical polymerization.Antibiotics were further installed into the hydrogels via ion-complexation with metal cations.These hydrogels exhibited significantly enhanced hydration,compared with polyacrylamide-based hydrogels,while featuring robust mechanical strength.Cationic metallopolymer hydrogels exhibited strong antifouling against oppositely charged proteins.These antibiotic-loaded hydrogels demonstrated a synergistic effect on the inhibition of bacterial growth and antifouling of bacteria,as a result of the unique ion complexation of cobaltocenium cations. | Hui Li Peng Yang JiHyeon Hwang Parasmani Pageni Alan W.Decho Chuanbing Tang | 2022 | Biomaterials Translational2022，3，2： | 0 |
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