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| 1 | Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer显示文摘BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive factors.AIM To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC patients.METHODS This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese hospitals.Means were compared through non-parametric Mann-Whitney tests.Receiver operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent variable.RESULTS This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of death.CONCLUSION Higher NLR is correlated with longer survival time.High LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT and dying.Patients with TSR and a pathological response have better OS and lower risk of dying. | Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza | 2022 | World Journal of Gastrointestinal Oncology2022，14，7： | 2 |
| 2 | Longitudinal outcomestudy of sessile serrated adenomas of the colorectum:an increasedrisk for subsequent right-sided colorectal carcinoma显示文摘 | Lu FI van Niekerk de W Owen D | 2010 | Am JSurg Pathol2010，34，7： | 1 |
| 3 | Hand,foot and mouth disease complicated with central nervous system involvement in Taiwan in 1980-1981显示文摘 | Chang LY Lee CY Kao CL Fang TY Lu CY Lee FI Huang LM | 2007 | J Formos Med Assoc2007，106，2： | 1 |
| 4 | Quantitative shear wave elastogra- phy: correlation with prognostic histologic features and immuno- histochemical biomarkers of breast cancer 显示文摘 | Au FW Ghai S Lu FI | 2015 | Acad Radiol2015，22，3： | 1 |
| 5 | The role of inhibin B as a basal determinant of ovarian reserve显示文摘 | C. Fi? icio&gbreve lu T. Kutlu S. Dem&inodot rba&scedil o&gbreve lu B. Mulayim | 2003 | Gynecological Endocrinology2003，，： | 1 |
| 6 | Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/beta-catenin pathway显示文摘 | Lu FI Sun YH Wei CY | 2014 | Nat Commun2014，5，： | 1 |
| 7 | Early follicular antimüllerian hormone as an indicator of ovarian reserve显示文摘 | Fiiciolu C Kutlu T Baglam E | 2006 | Fertil Steril2006，85，： | 1 |
| 8 | 早卵泡期抗苗勒激素作为卵巢储备的指示因子显示文摘Objective: To determine the predictive value of antimü llerian hormone (AMH) as a marker for ovarian reserve and to compare its value with the markers currently being used. Design: Prospective analysis. Setting: In vitro fertilization (IVF) clinic of a tertiary medical center. Patient(s): Fifty women undergoing assisted reproduction cycles. Intervention(s): None. Main Outcome Measure(s): Comparison of day- 3 serum AMH levels among women with less than five retrieved oocytes and five or more oocytes. Antral follicle count, mature oocyte count, age, basal follicle- stimulating hormone (FSH), estradiol (E2), maximum serum E2 levels, and pregnancy success were also compared. Result(s): The mean serum AMH levels of patients with more than five retrieved oocytes were found to be higher (0.67 ± 0.41 vs. 0.15 ± 0.11 pg/mL). Mature oocyte counts, antral follicle counts, and maximum E2 levels were found to be statistically significantly different in the two groups despite similar ages and levels of basal FSH and E2. Although the receiver operator characteristics analysis revealed that the most sensitive and specific indicator of ovarian reserve is the level of AMH, it does not indicate pregnancy success as well when 0.25 pg/mL is taken as a cut- off value. Conclusion(s): These data demonstrate an association between early follicular serum AMH and ovarian response, but no association with pregnancy success. | Fiicio■lu C. Kutlu T. Baglam E. Bakacak Z. 朱磊 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，2，6： | 0 |
| 9 | LASER FLASH SPECTROSCOPY STUDIES OF THE ANTHRACENEN,N-DIETHYLANILINE EXCIPLEX FORMATION IN γ-CYCLODEXTRIN显示文摘Gamma-cyclodextrin (γ-CD) was used to induce the formationof N,N-diethylaniline (DEA) exciplex in 15:85{φ=0.15)v/v EtOH-H2Obinary mixture.Measurements of the fluorescence spectra of anthracene inthe presence or absence of DEA and γ-CD show that γ-CD can form 1:1:1host/guest-Ⅰ/guest-Ⅱ inclusion complex with anthracene and DEA. | Ji Liang SHI Yuan Chao ZHANG Jia Liang GU Fang Lin LI Xi Kui JIANShanghai Institute of Organic Chemistry,Academia Sinica,345 Ling Ling Lu,Shanghai 200032.Nai Guang WANG Jun De CHENLaboratory of Laser Spectroscopy,Anhui Institute of Optics and Fi Academia Sinica,Hefei 230031. | 1992 | Chinese Chemical Letters1992，3，5： | 0 |
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