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| 1 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 2 | Effect of acupuncture at Renying(ST 9) on gene expression profile of hypothalamus in spontaneously hypertensive rats显示文摘OBJECTIVE: To investigate changes in gene expression profiles in the hypothalamus related to the effects of acupuncture at the Renying(ST 9) acupoint in spontaneously hypertensive(SH) rats.METHODS: We randomly divided 18 SH rats into Renying(ST 9) group and model control group, 9 body weight-matched Wistar-Kyoto rats were used as blank controls. Acupuncture was performed manually for 20-min daily over 28 d in the Renying(ST 9) group. Rat Gene 2.0 array technology was used for the determination of gene expression profiles and the screened key genes were verified by real-time quantitative polymerase chain reaction(RT-PCR) analyses.RESULTS: The different groups exhibited differential gene expression: compared with the blank control group, 48 genes were up-regulated and 91 genes were down-regulated in the model group;compared with the model group, 79 genes were up-regulated and 80 genes were down-regulated in Renying(ST 9) group. The RT-PCR results of the key genes including Chi3 l1, Ephx2, Klk1, 5-HT1 A and Cbs were consistent with that of gene chip analysis.CONCLUTION: Acupuncture at Renying(ST 9)could significantly lower the blood pressure of SH rats and affect their hypothalamic gene expression profile. Genes associated with the contraction of vascular smooth muscle and the regulation of inflammation, neurotransmitters may be involved in acupuncture's antihypertensive mechanism. | Guo Yan Lu Juan Liang Jingrong Zhao Ruili Xu Jing Zhang Wei Park Kibeum Zhu Shipeng Chen Huan Ma Liangxiao | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 4 |
| 3 | Uptake of graphene enhanced the photophosphorylation performed by chloroplasts in rice plants显示文摘New and enhanced functions were potentially imparted to the plant organelles after interaction with nanoparticles.In this study,we found that∼44%and∼29%of the accumulated graphene in the rice leaves passively transported to the chloroplasts and thylakoid,respectively,significantly enhanced the fluorescence intensity of chloroplasts,and promoted about 2.4 times higher adenosine triphosphate production than that of controls.The enhancement of graphene on the photophosphorylation was ascribed to two reasons:One is that graphene facilitates the electron transfer process of photosystem II in thylakoid,and the other is that graphene protects the photosystem II against photo-bleaching by acting as a scavenger of reactive oxygen species.Overall,our work here confirmed that graphene translocating in the thylakoid promoted the photosynthetic activity of chloroplast in vivo and in vitro,providing new opportunities for designing biomimetic materials to enhance the solar energy conversion systems,especially for repairing or increasing the photosynthesis activity of the plants grown under stress environment. | Kun Lu Danlei Shen Shipeng Dong Chunying Chen Sijie Lin Shan Lu Baoshan Xing Liang Mao | 2020 | Nano Research2020，13，12： | 4 |
| 4 | Fluid evolution and hydrocarbon accumulation model of ultra-deep gas reservoirs in Permian Qixia Formation of northwest Sichuan Basin,SW China显示文摘The fluid evolution and reservoir formation model of the ultra-deep gas reservoirs in the Permian Qixia Formation of the northwestern Sichuan Basin are investigated by using thin section,cathodoluminescence,inclusion temperature and U-Pb isotopic dating,combined with gas source identification plates and reservoir formation evolution profiles established based on burial history,thermal history,reservoir formation history and diagenetic evolution sequence.The fluid evolution of the marine ultra-deep gas reservoirs in the Qixia Formation has undergone two stages of dolomitization and one phase of hydrothermal action,two stages of oil and gas charging and two stages of associated burial dissolution.The diagenetic fluids include ancient seawater,atmospheric freshwater,deep hydrothermal fluid and hydrocarbon fluids.The two stages of hydrocarbon charging happened in the Late Triassic and Late Jurassic–Early Cretaceous respectively,and the Middle to Late Cretaceous is the period when the crude oil cracked massively into gas.The gas reservoirs in deep marine Permian strata of northwest Sichuan feature multiple source rocks,composite transportation,differential accumulation and late finalization.The natural gas in the Permian is mainly cracked gas from Permian marine mixed hydrocarbon source rocks,with cracked gas from crude oil in the deeper Sinian strata in local parts.The scale development of paleo-hydrocarbon reservoirs and the stable and good preservation conditions are the keys to the forming large-scale gas reservoirs. | LI Jianzhong BAI Bin BAI Ying LU Xuesong ZHANG Benjian QIN Shengfei SONG Jinmin JIANG Qingchun HUANG Shipeng | 2022 | Petroleum Exploration and Development2022，49，4： | 2 |
| 5 | Effect of nano-TiO2 on strength of naturally aged seeds and growth of spinach 显示文摘 | Zheng Lei Hong Fashui Lu Shipeng | 2005 | Biological Trace Element Research2005，104，1： | 1 |
| 6 | Virtualized Screen: A Third Element for Cloud-Mobile Con- vergence显示文摘 | LU Yan LI Shipeng SHEN Huifeng | 2011 | IEEE Multimedia2011，18，2： | 1 |
| 7 | Autocatalytic reduction-assisted synthesis of segmented porous PtTe nanochains for enhancing methanol oxidation reaction显示文摘Morphology engineering has been developed as one of the most widely used strategies for improving the performance of electrocatalysts.However,the harsh reaction conditions and cumbersome reaction steps during the nanomaterials synthesis still limit their industrial applications.Herein,one-dimensional(1D)novel-segmented PtTe porous nanochains(PNCs)were successfully synthesized by the template methods assisted by Pt autocatalytic reduction.The PtTe PNCs consist of consecutive mesoporous architectures that provide a large electrochemical surface area(ECSA)and abundant active sites to enhance methanol oxidation reaction(MOR).Furthermore,1D nanostructure as a robust sustaining frame can maintain a high mass/charge transfer rate in a long-term durability test.After 2,000 cyclic voltammetry(CV)cycles,the ECSA value of PtTe PNCs remained as high as 44.47 m^(2)·gPt^(-1),which was much larger than that of commercial Pt/C(3.95 m^(2)·gPt^(-1)).The high catalytic activity and durability of PtTe PNCs are also supported by CO stripping test and density functional theory calculation.This autocatalytic reduction-assisted synthesis provides new insights for designing efficient low-dimensional nanocatalysts. | Qiqi Zhang Tianyu Xia He Huang Jialong Liu Mengyuan Zhu Hao Yu Weifeng Xu Yuping Huo Congli He Shipeng Shen Cong Lu Rongming Wang Shouguo Wang | 2023 | Nano Research Energy2023，2，1： | 1 |
| 8 | Equivalent sample theory of networked control systems and its application显示文摘The equivalent sample theory and its application in analysis of networked control system (NCS) are presented.After analyzing NCS's scheduling in master-slave mode,the characteristics of time delay and sample are summarized.Looking on master station visiting the slave station as a special sample process,the theory of equivalent sample is presented.And based on it,the stability of a kind of NCS is analyzed.The criterion to determine the upper bound of transmission delay is introduced,which guarantees the stability.Finally,an example with simulation shows the availability and usability of this analysis method. | Ji Shunping Lu Yuping Wang Shipeng | 2008 | Journal of Systems Engineering and Electronics2008，19，6： | 0 |
| 9 | Type and distribution of Mid-Permian Maokou Formation karst reservoirs in southern Sichuan Basin,SW China显示文摘Based on the analysis of the responses of conventional logs such as natural gamma(GR), density(DEN), acoustic interval transit time(AC), compensated neutron(CNL), dual lateral resistivity(Rlld, Rlls), and caliper log(CAL), combined with drilling data,cores, thin section and productivity of 65 wells, the reservoirs in the Mid-Permian Maokou Formation of southern Sichuan Basin were divided into four types, fractured-vuggy, pore-vuggy, fractured and fractured-cavity. The main reservoirs in high productivity wells are fractured-vuggy and pore-vuggy. The reservoirs of Maokou Formation are generally thin, and can be divided into the upper reservoir segment(layer a of the second member to the third member of Maokou Formation, P_2 m^2 a-P_2 m^3) and the lower segment(layer b of the second member of Maokou Formation, P_2 m^2 b). The two reservoir segments are mainly controlled by two grain beaches during the sedimentation of P_2 m^2 a-P_2 m^3 and P_2 m^2 b, the vertical zonation of karst, and the fractures. The upper reservoir segment is generally better than the lower one in development degree and single well productivity, and is much thicker than the lower one. It is thicker in the Yibin-Zigong-Weiyuan-Dazu area, the southwestern area of Chongqing and the southeastern area of Luzhou, while the lower segment is thicker in the Neijiang-Zigong-Luzhou area and the Dazu-Luzhou area. The areas with big reservoir thickness at tectonic slope or syncline parts are the favorable exploration areas. | HUANG Shipeng JIANG Qingchun FENG Qingfu WU Ya LU Weihua SU Wang CHEN Xiaoyue REN Mengyi PENG Hui | 2019 | Petroleum Exploration and Development2019，46，2： | 0 |
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