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| 1 | Prevalence of and risk factors for tuberculosis among healthcare workers in Chinese tuberculosis facilities显示文摘Background:China is one of 22 countries with a high tuberculosis(TB)burden in the world.Healthcare workers(HCWs)have a high risk of contracting Mycobacterium tuberculosis infection due to insufficient infection control practices.We conducted a cross-sectional study to explore the prevalence of TB and its associated risk factors among HCWs in Chinese TB facilities.Methods:Two hundred and forty-one TB facilities employing a total of 9663 HCWs were selected from 12 provinces in China to represent healthcare settings at the provincial,prefectural,and county levels.Structured questionnaires were used to collect information on TB infection control practices and HCWs in those facilities.Data was double entered into EpiData 3.1;TB prevalence and associated risk factors were analyzed using SPSS 21.0 with bivariate and multivariate regression models.Results:The results showed that 71 HCWs had been diagnosed with TB,accounting for a prevalence of 760/100000.The multivariate analysis showed that associated risk factors included belonging to the age group of 51 years and above(aOR:6.17,95%CI:1.35-28.28),being a nurse(aOR=3.09,95%CI:1.15-8.32),implementation of 0-9 items of management measures(aOR=2.57,95%CI:1.37-4.80),and implementation of 0-1 items of ventilation measures(aOR=2.42,95%CI:1.31-4.47).Conclusion:This was the first national large sampling survey on TB prevalence among HCWs in China.It was found that the implementation of TB infection control practices in some facilities was poor.The TB prevalence in HCWs was higher than that in the general population.Therefore,TB infection control practices in Chinese medical facilities should be strengthened. | Xiao-Ning Wang Tian-Lun He Meng-Jie Geng Yu-Dan Song Ji-Chun Wang Min Liu Sarah Jayne Hoosdally Ana Luíza Gibertoni Cruz Fei Zhao Yu Pang Yan-Lin Zhao Guang-Xue He | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 2 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 3 | Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer显示文摘BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive factors.AIM To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC patients.METHODS This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese hospitals.Means were compared through non-parametric Mann-Whitney tests.Receiver operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent variable.RESULTS This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of death.CONCLUSION Higher NLR is correlated with longer survival time.High LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT and dying.Patients with TSR and a pathological response have better OS and lower risk of dying. | Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza | 2022 | World Journal of Gastrointestinal Oncology2022，14，7： | 2 |
| 4 | Restoration of arterial baroreflex function contributes to organ protection in spontaneously hypertensive rats treated with long-term hydrochlorothiazide mixture显示文摘 | Lu ZA Xie HH Xu LP | 2003 | Clin Exp Pharmacol Physiol2003，30，： | 1 |
| 5 | NF kappa B-inducing kinasedeficiency results in the development of a subset of regulatory Tcells, which shows a hyperproliferative activity upon glucocorti-coid-induced TNF receptor family-related gene stimulation 显示文摘 | Lu LF Gondek DC Scott ZA | 2005 | JImmunol2005，175，3： | 1 |
| 6 | Seed oil of Sapindus saponaria L. (Sapindaceae) as potential C16 to C22 fatty acids resource显示文摘 | Letícia Lovato Bruna Luíza Pelegrini Juliana Rodrigues Arildo José Braz de Oliveira Izabel Cristina Piloto Ferreira | 2014 | Biomass and Bioenergy2014，，： | 1 |
| 7 | Surgical management of renal cell carcinoma with inferior vena cava tumor thrombus显示文摘 | Sadi Kaplan Sinan Ekici R?za Do?an Metin Demircin Haluk ?zen Ilhan Pa?ao?lu | 2002 | The American Journal of Surgery2002，，3： | 1 |
| 8 | Effect of different levels of cigarette smoking on lipid pemxidation, glutathione enzymes and paraoxonase 1 activity in healthy people显示文摘 | Solak ZA Kabarog lu C Cok G | 2005 | Clin Exp Med2005，5，： | 1 |
| 9 | Calpain translocation and activation as pharmacological targets during myocardial ischemia/reperfusion显示文摘 | Víctor Hernando Javier Inserte Carmem Luíza Sartório Víctor M. Parra Marcos Poncelas-Nozal David Garcia-Dorado | 2010 | Journal of Molecular and Cellular Cardiology2010，，2： | 1 |
| 10 | Biochemical changer in primary culture of skeletal muscle cells following dimethoate exposure显示文摘 | Yang D Lu X Za Hang | 2002 | Toxicology2002，174，2： | 1 |
| 11 | Restoration of arterial baroreflexfunction contributes to organ protection in spontaneously hyper-tensive rats treated with long-term hydrochlorothiazide mixture显示文摘 | Lu ZA Xie HH Xu LP | 2003 | Clin Exp Pharmacol Physiol2003，30，12： | 1 |
| 12 | NF kappa B-inducing kinasedeficiency results in the development of a subset of regulatory Tcells, which shows a hyperproliferative activity upon glucocorti-coid-induced TNF receptor family-related gene stimulation 显示文摘 | Lu LF Gondek DC Scott ZA | 2005 | JImmunol2005，175，3： | 1 |
| 13 | Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity显示文摘 | Suziy de M. Bandeira Glaucevane da S. Guedes Lucas José S. da Fonseca André S. Pires Daniel P. Gelain José Claudio F. Moreira Luíza A. Rabelo Sandra Mary L. Vasconcelos Marília Oliveira F. Goulart Felipe Dal-Pizzol | 2012 | Oxidative Medicine and Cellular Longevity2012，，： | 1 |
| 14 | Evaluation of the genotoxicity and cytotoxicity of fexofenadine in cultured human peripheral blood lymphocytes显示文摘 | Kasurka CB Sekero?lu ZA Sekero?lu V | 2011 | Toxicol In Vitro2011，25，7： | 1 |
| 15 | NF kappa B-inducing kinasedeficiency results in the development of a subset of regulatory Tcells, which shows a hyperproliferative activity upon glucocorti-coid-induced TNF receptor family-related gene stimulation 显示文摘 | Lu LF Gondek DC Scott ZA | 2005 | JImmunol2005，175，3： | 1 |
| 16 | Clinical features of the initial cases of,2009pandemic influenza A (H1N1) virus infection in China显示文摘 | Cao B Li XW Mao Y Wang J Lu HZ Chen YS Liang ZA Liang L Zhang SJ Zhang B Gu L Lu LH Wang DY Wang C | | 0，，： | 1 |
| 17 | Proteomic analysis on the alteration of protein expression in gills of ayu (Plecoglossus ahivelis) associated with salinity change显示文摘 | Lu X J Chen J Huang ZA | 2010 | Comp Biochem Physiol:Part D2010，5，3： | 1 |
| 18 | Bitcoin:Exploring Price Predictability and the Impact of Investor Sentiment显示文摘This article addresses the predictability of Bitcoin’s price by examining relationships between Bitcoin and financial and emotional variables such as the Fear and Greed Index(FGI),the American Interest Rate(FED),and the Stock Market Index(NASDAQ).Through the use of statistical techniques such as the Johansen Cointegration Test and Granger Causality,as well as forecasting models,the study reveals that,despite the notorious volatility of the cryptocurrency market,it is possible to identify consistent behavioral patterns that can be successfully used to predict Bitcoin returns.The approach that combines VAR models and neural networks stands out as an effective tool to assist investors and analysts in making informed decisions in an ever-changing market environment. | Everton Anger Cavalheiro Paulo Sérgio Ceretta Luíza Roloff Falck | 2023 | Chinese Business Review2023，22，2： | 0 |
| 19 | Observatory science with eXTP显示文摘In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s. | Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig Alessandro Riggio Jerome Rodriguez Pablo Rodríguez-Gil Patrizia Romano Agata Rózańska Takanori Sakamoto Tuomo Salmi Ruben Salvaterra andrea Sanna andrea Santangelo Tuomas Savolainen Stéphane Schanne Hendrik Schatz LiJing Shao andy Shearer Steven N.Shore Ben W.Stappers Tod E.Strohmayer Valery F.Suleimanov Jirí Svoboda F.-K.Thielemann Francesco Tombesi Diego F.Torres Eleonora Torresi Sara Turriziani andrea Vacchi Stefano Vercellone Jacco Vink Jian-Min Wang JunFeng Wang Anna L.Watts ShanShan Weng Nevin N.Weinberg Peter J.Wheatley Rudy Wijnands Tyrone E.Woods Stan E.Woosley ShaoLin Xiong YuPeng Xu Zhen Yan George Younes WenFei Yu Feng Yuan Luca Zampieri Silvia Zane andrzej A.Zdziarski Shuang-Nan Zhang Shu Zhang Shuo Zhang Xiao Zhang Michael Zingale | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 0 |
| 20 | Using Support Vector Machines and neural networks to classify Merlot wines from South America显示文摘Wines with a clear geographical origin are an issue of interest for consumers and food industries.This paper presents a data mining study of Merlot wines from South America to identify the fingerprint of their geographical origin.A group of samples from Argentina(n=17),Brazil(n=12),Chile(n=48),and Uruguay(n=6)was analyzed.Twenty chemical compounds were determined by high-performance liquid chromatography(HPLC).These compounds include antioxidant activity,total polyphenols,total anthocyanins,individual anthocyanins and color.Four binary classification problems were performed(Brazil versus non-Brazil,Argentina versus non-Argentina,Chile versus non-Chile,and Uruguay versus non-Uruguay)to investigate the geographic characteristics of each country.Through the evaluation of binary classifications in our dataset it was possible to identify the main variables(chemical compounds)that discriminate between the countries.We used the following algorithms:Synthetic Minority over-sample Technique and under-sampling to balance the dataset of each classification approach,the Relief algorithm to obtain a variable importance ranking and the classifiers Support Vector Machines,Multilayer Perceptron and Radial Basis Function Network with dynamic decay adjustment.SVM model obtained the highest performance measures among the classifiers for each dataset(93.73%of accuracy for the Brazil versus non-Brazil,91.18%for the Argentina versus non-Argentina,79.16%for the Chile versus non-Chile,and 91.67%for the Uruguay versus non-Uruguay classification).These accuracies were achieved by the search of the possible variable subsets according to Relief for each classification approach.We found that some variables,such as DPPH,wine color and individual anthocyanins,are among the most important variables in the characterization of Merlot wines. | Nattane Luı´za Costa Laura Andrea Garcı´a Llobodanin Inar Alves Castro Rommel Barbosa | 2019 | Information Processing in Agriculture2019，6，2： | 0 |
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