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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | A rice high-afinity potassium transporter (HTK) conceals a calcium-permeable cation 显示文摘 | Lan W Z Wang W Wang S M Li L G Buchanan B B Lin H X Gao J P Luana S | 2010 | Proceedings of the National Academy of Sciences of the United States of America2010，107，15： | 1 |
| 3 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation 显示文摘 | LUANA S N JOSE T P B ANDREA P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 4 | Multi-element de- termination of Cu, Fe, Ni and Zn content in vegetable oils sam- pies by high-resolution continuum source atomic absorption spec- trometry and microemulsion sample preparation显示文摘 | Luana S N Jose T P B Andrea P F | 2011 | Food Chem- istry2011，127，2： | 1 |
| 5 | Optimizationof J3-glucosidase, |3-xylosidase and xylanase produc-tion by colletotrichum graminicoLa under solid-statefermentation and application in raw sugarcane trashsaccharification 显示文摘 | Ana L R L Z Cesar S?Luana P M | 2013 | Int J Mol Sci2013，14，2： | 1 |
| 6 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation 显示文摘 | Luana S Nunes L S Barbosa J T P | 2011 | Food Chemistry2011，127，2： | 1 |
| 7 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation显示文摘 | LUANA S N JOSE T P B ANDREA P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 8 | Multi-element determina-tion of Cu,Fe,Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and mi-croemulsion sample preparation显示文摘 | Luana S N Jose TPB Andrea P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 9 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorp- tion spectrometry and microemulsion sample preparation 显示文摘 | Luana S N Jose T P B Andrea P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 10 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation 显示文摘 | LUANA S N JOSE T P B ANDREA P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 11 | Characterization of authentic Italian extra-virgin olive oils by stable isotope ratios of C, O and H and mineral composition 显示文摘 | Federica C Roberto L Matteo P Luana B Daniedla B Giacomo G Giorgio N Giuseppe V | 2010 | Food Chemistry2010，118，4： | 1 |
| 12 | Development of a simple dry eye model in the albino rabbit and evaluation of some tear substitutes显示文摘 | Susi B Luana P Patrizia C | 1999 | Ophthalmic Res1999，31，2： | 1 |
| 13 | Development of a simple dry eye model in the albino rabbit and evaluation of some tear substitutes 显示文摘 | Susi B Luana P Patrizia C | 1999 | Ophthalmical Res1999，31，2： | 1 |
| 14 | Transcript profiling of papaya fruit reveals differentially expressed genes associated with fruit ripening显示文摘 | Joao P F Luana R B Franco M L | 2010 | Plant Science2010，179，3： | 1 |
| 15 | Bladder outlet obstruction index and maximal flow rate during urodynamic study as powerful predictors for the detection of urodynamic obstruction in women显示文摘 | Gravina G L Costa A M Ronchi P Galatioto G P Luana G Vicentini C | 2007 | Neurourol Urodyn2007，26，： | 1 |
| 16 | Development of a simple dry eye model in the albino rabbit and evaluation ofsome tear substi- tutes显示文摘 | Susi B Luana P Patrizia C | 1999 | Ophthalrnical Res1999，31，2： | 1 |
| 17 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation 显示文摘 | Luana S N Jose T P B Andrea P F | 2011 | Food Chemistry2011，127，2： | 1 |
| 18 | Multi-element determination of Cu, Fe, Ni and Zn content in veg- etable oils samples by high-resolution continuum source atomic ab- sorption spectrometry and microemulsion sample preparation 显示文摘 | Luana S Nunesa Jose T P Barbosaa AndrEa P Fernandesa | 2011 | Food chemistry2011，127，2： | 1 |
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