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| 1 | Curcumin induces differentiation of embryonic stem cells through possible modulation of nitric oxide-cyclic GMP pathway显示文摘Curcumin,an active ingredient of dietary spice used in curry,has been shown to exhibit anti-oxidant,anti-inflammatory and anti-proliferative properties.Using EB directed differentiation protocol of H-9 human em-bryonic stem(ES)cells;we evaluated the effect of cur-cumin(0-20μmol/L)in enhancing such differentiation.Our results using real time PCR,western blotting and immunostaining demonstrated that curcumin signifi-cantly increased the gene expression and protein levels of cardiac specific transcription factor NKx2.5,cardiac troponin I,myosin heavy chain,and endothelial nitric oxide synthase during ES cell differentiation.Further-more,an NO donor enhanced the curcumin-mediated induction of NKx2.5 and other cardiac specific proteins.Incubation of cells with curcumin led to a dose depend-ent increase in intracellular nitrite to the same extent as giving an authentic NO donor.Functional assay for second messenger(s)cyclic AMP(cAMP)and cyclic GMP(cGMP)revealed that continuous presence of cur-cumin in differentiated cells induced a decrease in the baseline levels of cAMP but it significantly elevated baseline contents of cGMP.Curcumin addition to a cell free assay significantly suppressed cAMP and cGMP degradation in the extracts while long term treatment of intact cells with curcumin increased the rates of cAMP and cGMP degradation suggesting that this might be due to direct suppression of some cyclic nucleo-tide-degrading enzyme(phosphodiesterase)by curcu-min.These studies demonstrate that polyphenol curcu-min may be involved in differentiation of ES cells partly due to manipulation of nitric oxide signaling. | Kalpana Mujoo Lubov ENikonoff Vladislav G Sharin Nathan SBryan Alexander YKots Ferid Murad | 2012 | Protein & Cell2012，3，7： | 5 |
| 2 | Intracellular signaling and hepatocellular carcinoma显示文摘 | Polina Iakova Lubov Timchenko Nikolai A. Timchenko | 2010 | Seminars in Cancer Biology2010，，1： | 2 |
| 3 | 俄引水稻种质的直播特性研究显示文摘为获得具有优良直播特性的种质,以俄罗斯引进的10份水稻资源为材料,研究中胚轴长度、低温发芽能力和淹水条件下发芽率等与水稻直播相关的特性。结果表明:‘LIDER’‘、ATLANT’和‘OLIMP’低温条件下萌发速度最快,‘LIDER’、‘OLIMP’、‘ATLANT’、‘NATASHA’、‘ISTOK’和‘PARTNER’具有较好的低温发芽能力;‘ATLANT’、‘ISTOK’、‘RAPANZ’、‘GAMMA’、‘OLIMP’和‘SONET’的中胚轴长度与‘绿香粳28’在5%水平上达显著差异;在缺氧条件下,所有的品种间的发芽率均达极显著差异,但俄罗斯品种均优于对照。在所有引进的俄罗斯10品种中,‘ATLANT’与直播相关的综合性状最为突出,中胚轴长度、低温发芽能力和淹水条件下发芽率均极显著优于对照品种。 | 林翠香 宋龙飞 Sergey Garkusha 宋丰顺 Zhanna Mukhina 滕斌 甘泉 Victor Kovalyov 余海兵 Lubov Yesaulova 倪大虎 | 2021 | 中国农学通报2021，37，23： | 2 |
| 4 | Late miocene to pliocene paleogeography of the Paratethys and its relation to the Mediterranean显示文摘 | PoPov S V IRINA G S LUBOV B I | 2006 | Pataeogeography Palaeoclimatology Palaeoecology2006，238，： | 1 |
| 5 | On - line solid - phase extraction and HPLC determination of polyeyclie aromatic hydrocarbons in water using fluorocarbon polymer sorbents 显示文摘 | Lubov O Mikhail S Grigoriy T | 2005 | Analytica Chimica Aeta2005，538，： | 1 |
| 6 | Endothelinrelease:a maker for severity of exercise-induced ischemia显示文摘 | Lubov T Marmot A Gorenberg M | 2001 | Int J Cardiol2001，79，1： | 1 |
| 7 | Tetraspanin protein CD 9 interacts with metalloprotease CD 10 and enhances its release via exosomes显示文摘 | Dmitriy Mazurov Lubov Barbashova Alexander Filatov | 2013 | FEBS J2013，，5： | 1 |
| 8 | Substrates intraatrial andinteratrial conduction in the atrial septum:Anatomical studv on 84human hearts显示文摘 | Pyotr C Platonov Lubov Mitrofanova | 2008 | Heart Rhythm2008，5，8： | 1 |
| 9 | Intracellular signaling and hepatocellular carcinoma显示文摘 | Polina Iakova Lubov Timchenko Nikolai A. Timchenko | 2010 | Seminars in Cancer Biology2010，，1： | 1 |
| 10 | Endothelin release: amaker for severity of exercise - induced ischemia显示文摘 | LUBOV T MMAMOR A GORENBERG M | 2001 | Int J Cardi - ol2001，79，1： | 1 |
| 11 | Reduction of matrix interference during the atomic absorption determination of lead and cadmium in strongly interfering matrix samples using a two-step atomizer with vaporizer purging显示文摘 | ILIA L G YURI A V LUBOV A V | 1999 | Spectrochimica Aeta Part B : Atomic Spoctroscopy1999，54，5： | 1 |
| 12 | Endotheline release a marker for severity of exercise - induced ischemia显示文摘 | Lubov T Marker A Gorenberg M | 2001 | Int J Cardiol2001，79，1： | 1 |
| 13 | On-line Solid-phase Extraction and HPLC Determination of Polycyclic Aromatic Hydrocarbons in Water Using Fluorocarbon Polymer Sorbents显示文摘 | Lubov O Mikhail S Grigoriy T | 2005 | Analytica Chimica Acta2005，538，： | 1 |
| 14 | Methylprednisolone Use is Associated with Endothelial Cell Activation Following Cardiac Surgery显示文摘 | Vladimir V. Lomivorotov Sergey M. Efremov Andrey P. Kalinichenko Igor A. Kornilov Lubov G. Knazkova Alexandr M. Chernyavskiy Vladimir N. Lomivorotov Alexander M. Karaskov | 2012 | Heart, Lung and Circulation2012，，： | 1 |
| 15 | Endothelin release:a maker for severity of exercise-induced ischemia显示文摘 | Lubov T Marmor A Gorenberg M | 2001 | Int J Cardiol2001，79，1： | 1 |
| 16 | Predicting the sensory crispness of coated turkey breast by its acoustic signature显示文摘 | Lubov Iliassafov Eyal Shimoni | 2007 | Food Research International2007，40，7： | 1 |
| 17 | Endothelin release: a maker for severity of exercise-induced ischemia显示文摘 | Lubov T Marmor A Gorenberg M | 2001 | Int J Cardiol2001，79，1： | 1 |
| 18 | Endothelin release: a marker for severity of exercise-induced isehemia显示文摘 | Lubov T Marmor A Gorenberg M | 2001 | Int J Cardiol2001，79，1： | 1 |
| 19 | Competition of CUGBP1 and celreticulin for the regulation of p21 translation determines cell fate显示文摘 | IAKOVA P WANG G L LUBOV T | 2004 | The EMBO Journal2004，23，2： | 1 |
| 20 | Predicting the sensory crispness of coated turkey breast by its acoustic signature显示文摘 | Lubov Iliassafov Etal Shimoni | 2007 | Food Re- search International2007，40，7： | 1 |
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