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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Mutation in the follicle stimuLating hormone receptor gene causes hereditary hypergonadotropic ovarian failurel 显示文摘 | Aittomaki K Lucena JL Pakarinen P | 1995 | Cell1995，82，： | 1 |
| 3 | Laser Induced Breakdown Spectrometry of Vanadium in Titania Supported Silica Catalysts 显示文摘 | LUCENA P CABALIN L M PARDO E | 1998 | Talanta1998，47，： | 1 |
| 4 | Fiberoptic bronchoscopy in a respiratory intensive care unit显示文摘 | Lucena CM Martinez-Olondris P Badia JR | 2012 | Med Intensiva2012，36，6： | 1 |
| 5 | Seismic ground roll time-frequency filtering using the gaussian wavelet transform显示文摘 | Corso G Kuhn P S Lucena L S | 2003 | Physica A2003，318，： | 1 |
| 6 | Seismic ground roll time-frequency filtering using the gaussian wavelet transform显示文摘 | CORSO G KUHN P S LUCENA L S | 2003 | Physical A2003，318，3： | 1 |
| 7 | Location and detection of explosive-contaminated human fingerprints on distant targets using standoff laser-induced breakdown spectrosco- py显示文摘 | Lucena P Gaona I Moros J | 2013 | Spectrochimica Acta Part B2013，85，： | 1 |
| 8 | Significance of the presence of lymphocytes in the cytological analysis of transbronchial needle aspiration显示文摘 | Lucena CM Agusti C Martinez-Olondris P | 2011 | Arch Bronconeumol2011，47，3： | 1 |
| 9 | Mutation in the folli- cle-stimulating hormone receptor gene causes hereditary hypergo- nadotropie ovarian failure 显示文摘 | Aittomaki K Lucena J Pakarinen P | 1995 | Cell1995，82，6： | 1 |
| 10 | Evaluating two quantitative ethnobotanical techniques显示文摘 | Albuquerque U P Lucena R F P Monteiro J M | 2006 | Ethnobotany Research & Applications2006，，4： | 1 |
| 11 | Software Process Representation and Analysis for Framework Instantiation显示文摘 | Oliveira T C Filho I M de Lucena C J P | 2004 | Software Engineering IEEE Transactions on2004，30，3： | 1 |
| 12 | Isocratic ion-pair high- performance liquid chromatographic method for the determination of various iron (III) chelates显示文摘 | LUCENA J J BARAK P HERNANDEZ A L | 1996 | Journal of Chromatography A1996，727，2： | 1 |
| 13 | Use of the stable isotope 57 Fe to track the efficacy of the foliar appli- cation of lignosulfonate/Fe3+ complexes to correct Fe defi- ciencies in cucumber plants 显示文摘 | Rodrfguez-Lucena P Benedicto A Lucena JJ | 2011 | Journal of the Science of Food & Agriculture2011，91，3： | 1 |
| 14 | Comparison of iron chelates and complexes supplied as foliar sprays and in nutrient solu- tion to correct iron chlorosis of soybean显示文摘 | Rodriguez-Lucena P Lucena JJ | 2010 | Journal of Plant Nutrition & Soil Science2010，173，1： | 1 |
| 15 | Seismic ground roll time-frequency filtering using the gaussian wavelet transform显示文摘 | CORSO G KUHN P S LUCENA L S | 2001 | Physiea A2001，318，2003： | 1 |
| 16 | Iron supply to soybean plants through the foliar application of IDHA/Fe3 +: effect of plant nutritional status and adjuvants 显示文摘 | Rodrlguez - Lucena P Ropero E Hemrndez - Apaolaza L | 2010 | Journal of the Science of Food and Agriculture2010，90，15： | 1 |
| 17 | Mutation in the follicle-stimulating hormone receptor gene causes hereditary hy- pergonadotropic ovarian failure显示文摘 | Aittomaki K Lucena J L D Pakarinen P | 1995 | Cell1995，82，6： | 1 |
| 18 | Successful ongoing pregnancies after vitrification of oocytes 显示文摘 | Lucena E Bemal D P Lucena C | 2006 | Fertil Steril2006，85，1： | 1 |
| 19 | Forecasting Brazil’s crude oil production using a multi-Hubbert model variant显示文摘 | Saraiva T A Szklo A Lucena A F P | 2014 | Fuel2014，115，： | 1 |
| 20 | Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure 显示文摘 | Aittomaki K Lucena J L Pakarinen P | 1995 | Cell1995，82，6： | 1 |
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