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| 1 | Titanium dioxide induced inflammation in the small intestine显示文摘AIM:To investigate the effects of titanium dioxide (TiO2) nanoparticles (NPTiO 2 ) and microparticles (MPTiO 2 ) on the inflammatory response in the small intestine of mice. METHODS: Bl 57/6 male mice received distilled water suspensions containing TiO 2 (100 mg/kg body weight) as NPTiO 2 (66 nm), or MPTiO 2 (260 nm) by gavage for 10 d, once a day; the control group received only distilled water. At the end of the treatment the duodenum, jejunum and ileum were extracted for assessment of cytokines, inflammatory cells and titanium content. The cytokines interleukin (IL)-1b, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17, IL-23, tumor necrosis factor-α (TNF-α), intracellular interferon-γ (IFN-γ) and transforming growth factor-β (TGF-β) were evaluated by enzyme-linked immunosorbent assay in segments of jejunum and ileum (mucosa and underlying muscular tissue). CD4 + and CD8 + T cells, natural killer cells, and dendritic cells were evaluated in duodenum, jejunum and ileum samples fixed in 10% formalin by immuno-histochemistry. The titanium content was determined by inductively coupled plasma atomic emission spectrometry. RESULTS: We found increased levels of T CD4 + cells (cells/mm 2 ) in duodenum:NP 1240 ± 139.4, MP 1070 ± 154.7 vs 458 ± 50.39 (P < 0.01); jejunum:NP 908.4 ± 130.3, MP 813.8 ± 103.8 vs 526.6 ± 61.43 (P < 0.05); and ileum:NP 818.60 ± 123.0, MP 640.1 ± 32.75 vs 466.9 ± 22.4 (P < 0.05). In comparison to the control group, the groups receiving TiO 2 showed a statistically significant increase in the levels of the inflammatory cytokines IL-12, IL-4, IL-23, TNF-α, IFN-γ and TGF-β. The cytokine production was more pronounced in the ileum (mean ± SE):IL-12: NP 33.98 ± 11.76, MP 74.11 ± 25.65 vs 19.06 ± 3.92 (P < 0.05); IL-4: NP 17.36 ± 9.96, MP 22.94 ± 7.47 vs 2.19 ± 0.65 (P < 0.05); IL-23: NP 157.20 ± 75.80, MP 134.50 ± 38.31 vs 22.34 ± 5.81 (P < 0.05); TNFα: NP 3.71 ± 1.33, MP 5.44 ± 1.67 vs 0.99± 019 (P < 0.05); IFNγ: NP 15.85 ± 9.99, MP 34.08 ± 11.44 vs 2.81 ± 0.69 (P < 0.05); and TGF-β: NP 780.70 ± 318.50, MP 1409.00 ± 502.20 vs 205.50 ± 63.93 (P < 0.05). CONCLUSION:Our findings indicate that TiO2 particles induce a Th1-mediated inflammatory response in the small bowel in mice. | Carolina Maciel Nogueira Walter Mendes de Azevedo Maria Lucia Zaidan Dagli Sérgio Hiroshi Toma AndréZonetti de Arruda Leite Maria Laura Lordello Iêda Nishitokukado Carmen Lúcia Ortiz-Agostinho Maria IrmaSeixas Duarte Marcelo Alves Ferreira Aytan Miranda Sipahi | 2012 | World Journal of Gastroenterology2012，18，34： | 8 |
| 2 | The Antioxidant Activity of Coumarins and Flavonoids显示文摘 | Guilherme Borges Bubols Damiana da Rocha Vianna Alexander Medina-Remon Gilsane von Poser Rosa Maria Lamuela-Raventos Vera Lucia Eifler-Lima Solange Cristina Garcia | 2013 | Mini-Reviews in Medicinal Chemistry2013，，3： | 1 |
| 3 | Photoluminescence emissions of Ca_(1-x)WO_(4):xEu^(3+):Bridging between experiment and DFT calculations显示文摘In this work,the impact of the doping process on the photoluminescence emission of CaWO_(4) as a function of the concentration of Eu^(3+) cation(0.01 mol%,0.02 mol%,0.04 mol%,0.06 mol%,0.08 mol%,and 0.10 mol%) is discussed in detail.Ca_(1-x)WO~4:xEu^(3+) samples were successfully synthesized by a simple coprecipitation method followed by microwave irradiation.The blue shift in the absorption edge confirms the quantum confinement effect and the band gap energy covers the range from 3.91 to 4.18 eV,as the amount of Eu^(3+) cations increases.The experimental results are sustained by first-principles calculations,at the density functional theory level,to decipher the geometry and electronic properties,thereby enabling a more accurate and direct comparison between theory and experiment for the Ca_(1-x)WO_(4):xEu^(3+) structure. | Amanda Fernandes Gouveia Marcelo Assis Lara Kelly Ribeiro Aline Estefany Brandao Lima Eduardo de Oliveira Gomes Daniele Souza Yara Gobato Galvao Ieda Lucia Viana Rosa Geraldo Eduardo da Luz Jr Eva Guillamón Elson Longo Juan Andrés Miguel Angel San-Miguel | 2022 | Journal of Rare Earths2022，40，10： | 1 |
| 4 | Agressive inflammatory myofibroblastic tumor of the liver with underlying schistosomiasis:A case report显示文摘Inflammatory myofibroblastic tumor(IMT)occurs infrequently in the liver.It is controversial whether it represents a low grade mesenchymal neoplasm or a reactive inflammatory lesion.Local recurrence and metastasis are rare and some tumors are associated with infectious agents.We report on a case of a large and partially resected IMT with local recurrence and diaphragm and kidney infiltration detected on routine surveillance two years later.Histologically,the tumor showed spindle cells without atypia,mitosis or necrotic areas in a myxoid and collagenized background with inflammatory cells.In the liver portal tracts,granulomatous lesions with viable eggs of Schistosoma mansoni were identified.Immunohistochemistry demonstrated spindle cells which were smooth-muscle actin and vimentin positive.In conclusion,this case points out that these histological patterns do not predict the aggressive biological behavior of the lesion.A reason for the recurrence and the infiltration may be incomplete tumor resection.Further investigation is necessary in order to better clarify an infectious cause in some IMTs. | Vera Lucia Pannain Juliana Vial Passos Ariovaldo da Rocha Filho Cristiane Villela-Nogueira Adriana Caroli-Bottino | 2010 | World Journal of Gastroenterology2010，16，33： | 1 |
| 5 | CHRONIC HEPATITIS C: HEPATIC IRON CONTENT DOES NOT CORRELATE WITH RESPONSE TO ANTIVIRAL THERAPY显示文摘 | Pereira Patricia da Silva Fucuta Silva Ivonete Sandra de Souza E Uehara Silvia Naomi de Oliveira Emori Christini Takemi Lanzoni Valéria Pereira Silva Antonio Eduardo Benedito Ferraz Maria Lucia Gomes | 2009 | Revista do Instituto de Medicina Tropical de S茫o Paulo2009，，6： | 1 |
| 6 | Cush- ing's syndrome in pregnancy:an overview 显示文摘 | Lucio Vilar Maria da Conceicao Freitas Lucia Helena CL | 2007 | Arq Bras Endocrinol Metabo12007，51，8： | 1 |
| 7 | Histological evolution of hepatitis C virus infection after renal transplantation显示文摘 | Silvia Naomi Oliveira Uehara Christini Takemi Emori Patrícia da Silva Fucuta Pereira Renata M. Perez José Osmar Medina Pestana Valéria Pereira Lanzoni Ivonete Sandra Souza e Silva Antonio Eduardo Benedito Silva Maria Lucia Cardoso Gomes Ferraz | 2012 | Clin Transplant2012，，6： | 1 |
| 8 | Total Occlusion of Anterior Descending Artery (AD) without ST-Segment Elevation: DE Winter Pattern显示文摘 | Ana Carolina Brito de Alcantara Francisco Marcelo Sobreira Filho Danielli Oliveira da Costa Lino Lucia de Sousa Belem Carlos Jose Mota de Lima | 2018 | Journal of Pharmacy and Pharmacology2018，6，6： | 1 |
| 9 | The absolute configuration of 1- (3', 4'-dihydroxyeinnamoyl) eyelopentane-2,3-diol from the amazonian tree Chimarrhis turbinate 显示文摘 | Carmen Lucia Cardoso Vanderlan da Silva Bolzani Dulce Helena Siqueira Silva | 2006 | Journal of Nature Product2006，69，： | 1 |
| 10 | Investigation of NBR-cellulose (II) : Nocomposites by rheometric and equilibrium swelling properties 显示文摘 | Lapa Vera Lucia Da C De Oliveira Patricia D Visconte Leila Lea Y | 2008 | Polymer2008，60，2： | 1 |
| 11 | Revisited anatomy of lhe recurrent laryngeal nerves 显示文摘 | Guglielmo A Luca R Lucia DA | 2004 | Am J Surg2004，187，2： | 1 |
| 12 | Investigation of NBR-cellulose (Ⅱ) : Nocomposites by rheometric and equilibrium swelling properties 显示文摘 | Lapa Vera Lucia Da C De Oliveira Patricia D Visconte Leila Lea Y | 2008 | Folymer2008，60，2： | 1 |
| 13 | Right ventricular ejeetion fraction and left ventricular dyssynchrony by 3d eeho eorrelate with functional impairment in patients with dilated eardiomyopathy显示文摘 | Antonello DA Rita G Lucia R | 2011 | J Card Fail2011，17，4： | 1 |
| 14 | Determination of Noble Metals in Biological Samples by Electrothermal Vaporization Inductively Coupled Plasma Mass Spectrometry, Following Cloud Point Extraction显示文摘 | Marcia Andreia Mesquita da Silva Vera Lucia Azzolin Frescura Adilson Jose Curtius | | 0，，： | 1 |
| 15 | Encapsulation of TiO2 by emulsion polymerization with methyl methacrylate (MMA)显示文摘 | ADRIANO MARIM DE OLIVEIRA MARIA LUCIA CAETANO PINTO DA SILVA | | 0，，55： | 1 |
| 16 | Polymorphism analysis in genes of the somatotropic axis in Nellore cattle selected for growth显示文摘 | Diercles Francisco Cardoso Fábio Ricardo Pablos de Souza Gregório Miguel Ferreira de Camargo Patrícia Dias da Silva Fonseca Larissa Fernanda Simielli Fonseca Camila Urbano Braz Arione Augusti Boligon Maria Eugênia Zerlotti Mercadante Lucia Galv?o de Albuq | 2014 | Gene2014，，2： | 1 |
| 17 | Encapsulation of TiO 2 by emulsion polymerization with methyl methacrylate (MMA)显示文摘 | ADRIANO MARIM DE OLIVEIRA MARIA LUCIA CAETANO PINTO DA SILVA GIZELDA MARIA ALVES | | 0，，55： | 1 |
| 18 | Revisited anatomy of the recurrent laryngeal nerves显示文摘 | Guglielmo A Luca R Lucia DA | 2004 | Am J Surg2004，187，2： | 1 |
| 19 | Investigation of NBR-cellulose Ⅱ nanocomposites by rheometric and equilibrium swelling properties 显示文摘 | Lapa Vera Lucia Da C De Oliveira Patricia D Visconte Leila Lea Y | 2008 | Polymer2008，60，2： | 1 |
| 20 | The effect of a minor constituent of essential oil from Citrus aurantium : The role of β-myrcene in preventing peptic ulcer disease显示文摘 | Flavia Bonamin Thiago M. Moraes Raquel C. dos Santos Hélio Kushima Felipe M. Faria Marcos A. Silva Ivan V. Junior Leonardo Nogueira Tais M. Bauab Alba R.M. Souza Brito Lucia R.M. da Rocha Clélia A. Hiruma-Lima | 2014 | Chemico-Biological Interactions2014，，： | 1 |
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