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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Activity theory as a framework for designing constructivist learning environments显示文摘 | DAVID H JONASSEN LUCIA ROHRER MURPHY | | 0，，01： | 1 |
| 3 | Identification of Dengue virus infected cells in paraffin- embedded tissue using in situ polymerase chain reaction and DNA hybridization 显示文摘 | Lucia H L Kangwanpong D | 1994 | J Virol Meth1994，48，： | 1 |
| 4 | Volatile Organic Compounds from the Clone Populus x canadensis “Conti” Associated with Megaplatypus mutatus Attack显示文摘 | Alejandro Lucia Paola González-Audino Héctor Masuh Taya Chermenskaya | 2014 | Psyche2014，，： | 1 |
| 5 | Comparison and development of new graph-based landscape connectivity indices: towards the prioritization of habitat patches and corridors for conservation显示文摘 | LUCIA P H SANTIAGO S | 2006 | Landscape Ecology2006，21，： | 1 |
| 6 | 2 Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alphastimulated gene 6 显示文摘 | Garcia G E Wisniewski H G Lucia M S | 2006 | Clin Cancer Res2006，12，31： | 1 |
| 7 | Virulence factors of Vibrio metschnikovii strains isolated from fish in Brazil显示文摘 | MARIA H M LUCIA B MARIA L B | 2007 | Food Control2007，18，6： | 1 |
| 8 | A double resonance approach to submillimeter/terahertz remote sensing at atmospheric pressure显示文摘 | LUCIA F C PETKIE D T EVERITT H O | 2009 | IEEE journal of quantum electronics2009，45，2： | 1 |
| 9 | A new habitat availability index to integrate connectivity in landscape conservation planning: Comparison with existing indices and application to a case study显示文摘 | SANTIAGO S LUCIA P H | 2007 | Landscape and Urban Planning2007，，： | 1 |
| 10 | Single impact trauma in human early-stage osteoarthritic cartilage : Implication of prostaglandin D2 but no additive effect of IL-1β on cell suxvival显示文摘 | Helga J Cathrin H Lucia R | 2011 | International Journal of Molecular Medicine2011，28，2： | 1 |
| 11 | A comparative evaluation of Si C power devices for high-performance domestic induction heating显示文摘 | SARNAGO H LUCIA O BURDIO J M | 2015 | Industrial Electronics IEEE Transactions on2015，62，8： | 1 |
| 12 | Modulation scheme for improved operation of an RB-IGBT-based resonant inverter applied to domestic induction heating显示文摘 | Sarnago H Lucia O Mediano A | 2013 | IEEE Transactions on Industrial Electronics2013，60，5： | 1 |
| 13 | Impact of spatial scale on the identification of critical habitat patches for the maintenance of landscape connectivity显示文摘 | LUCIA P H SANTIAGO S | 2007 | Landscape and Urban Planning2007，，： | 1 |
| 14 | Intemet performance monitoring 显示文摘 | THOMASM C LUCIA H | 2002 | IEEE Communication2002，90，9： | 1 |
| 15 | Emotional Brand Attachment and Brand Personality: The Relative Importance of the Actual and the Ideal Self 显示文摘 | Lucia M Harley K Wayne D H Bettina N | 2011 | Journal of Marketing2011，75，4： | 1 |
| 16 | Characterisation of electrochemically deposited Ni-Mo alloy coatings 显示文摘 | Luciana S Sanches Sergio H Domingues Claudia E B Marino Lucia H Mascaro | 2004 | Electrochemistry Communications2004，6，6： | 1 |
| 17 | Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment显示文摘 | LUCIA H M L M SANTOS ARAUJO A N FACHINI A | 2010 | Journal of Hazardous Materials2010，175，13： | 1 |
| 18 | Relativistic electronic structure of an icosahedral Au12Pd cluster显示文摘 | Ramiro A P Lucia H A | 1999 | Chem Phys Lett1999，303，： | 1 |
| 19 | α-Lipoic Acid in Liver Metabolism and Disease显示文摘 | Juanita Bustamante John K Lodge Lucia Marcocci Hans J Tritschler Lester Packer Bertrand H Rihn | 1998 | Free Radical Biology and Medicine1998，，： | 1 |
| 20 | Vaccine-associated paralytic poliomyelitis in Brazil,1989-1995显示文摘 | Lucia H Claudio J | 2000 | Pan Am J Public Health2000，7，4： | 1 |
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