| 2 | Chrysin ameliorates podocyte injury and slit diaphragm protein loss via inhibition of the PERK-elF2α-ATF-CHOP pathway in diabetic mice显示文摘Glomerular 上皮的 podocytes 是在经由他们的脚过程维持 glomerular 过滤障碍的正常功能起一个关键作用的高度专业化的房间。Chrysin (5,7-dihydroxyflavone ) 是在 propolis 和蘑菇发现有的自然 flavonoid 反煽动性,抗氧化剂和 anticancer 性质。这研究试图在高暴露葡萄糖的 podocytes 并且在 db/db 老鼠肾在 podocyte apoptotic 损失和裂缝隔膜蛋白质缺乏上评估 chrysin 的 renoprotective 效果。到在 vitro 引起 glomerular podocyte apoptosis 的高葡萄糖(33 mmol/L ) 的暴露,它是 dose-dependently 通过 DNA 破碎的减小由无毒的 chrysin (1-20 mol/L ) 稀释了。Chrysin 处理 dose-dependently 恢复了增加的 Bax/Bcl-2 比率,并且在高暴露葡萄糖的肾的 podocytes 压制了 Apaf-1 正式就职和提高的细胞色素 c 版本。在糖尿病的 db/db 老鼠, chrysin 的口头的管理(10 mgf 1.84 ??? ?? | Min-Kyung KANG Sin-Hye PARK Yun-Ho KIM Eun-Jung LEE Lucia Dwi ANTIKA DongYeon KIM Yean-Jung CHOi Young-Hee KANG | 2017 | Acta Pharmacologica Sinica2017，38，8： | 9 |
| 3 | Gaining community entry with survivors for forensic human rights and humanitarian intervention显示文摘As forensic humanitarian and forensic human rights anthropology has continued to evolve,an ongoing concern in the field is meaningful engagement with survivors and the imperative to do no harm.For forensic anthropologists attempting to engage in grassroots forensic intervention,unaffiliated with an international investigation,means for effectively accessing and engaging communities has not been widely discussed.Here,forensic anthropologists draw on multiple,cross-cultural contexts to discuss methods and techniques for introducing forensic partnerships to communities.To do this,the scientist must consider their positionality as well as that of the stakeholders,develop effective local relationships,and consider a community-grounded approach.This paper argues that drawing on broader cultural anthropological training,ultimately informs one’s ability to gain entry into at-risk and vulnerable communities while minimizing harm.To illustrate this point,examples are drawn from Canada,Uganda,Cyprus,and Somaliland. | Jaymelee Kim Lucia Elgerud Hugh Tullerc | 2022 | Forensic Sciences Research2022，7，3： | 1 |
| 7 | Controlling the electro-optic response of a semiconducting perovskite coupled to a phonon-resonant cavity显示文摘Optical cavities,resonant with vibrational or electronic transitions of material within the cavity,enable control of light-matter interaction.Previous studies have reported cavity-induced modifications of chemical reactivity,fluorescence,phase behavior,and charge transport.Here,we explore the effect of resonant cavity-phonon coupling on the transient photoconductivity in a hybrid organic-inorganic perovskite.To this end,we measure the ultrafast photoconductivity response of perovskite in a tunable Fabry–Pérot terahertz cavity,designed to be transparent for optical excitation.The terahertz-cavity field-phonon interaction causes apparent Rabi splitting between the perovskite phonon mode and the cavity mode.We explore whether the cavity-phonon interaction affects the material’s electron-phonon interaction by determining the charge-carrier mobility through photoconductivity.Despite the apparent hybridization of cavity and phonon modes,we show that the perovskite properties in both ground(phonon response)and excited(photoconductive response)states remain unaffected by the tunable light-matter interaction.Yet the response of the integral perovskite-terahertz optical cavity system depends critically on the interaction strength of the cavity with the phonon:the transient terahertz response to optical excitation can be increased up to threefold by tuning the cavity-perovskite interaction strength.These results enable tunable switches and frequency-controlled induced transparency devices. | Lucia Di Virgilio Jaco J.Geuchies Heejae Kim Keno Krewer Hai Wang Maksim Grechko Mischa Bonn | 2023 | Light(Science & Applications)2023，12，9： | 0 |
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