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| 1 | Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis显示文摘AIM: To assess the relationship between vitamin D re-ceptor (VDR) gene polymorphisms and the presence of hepatocellular carcinoma (HCC). METHODS: Two-hundred forty patients who underwent liver transplantation were studied. The etiologies of liver disease were hepatitis C (100 patients), hepatitis B (37) and alcoholic liver disease (103). A group of 236 healthy subjects served as controls. HCC in the explanted liver was detected in 80 patients. The following single nucle-otide gene polymorphisms of the VDR were investigatedby polymerase chain reaction and restriction fragment length polymorphism: FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) (BAT). RESULTS: The frequencies of genotypes in patients without and with HCC were for FokI F/F = 69, F/f = 73, f/f = 18 and F/F = 36, F/f = 36, f/f = 8; BsmI b/b = 45, B/b = 87, B/B = 28 and b/b = 33, B/b = 35, B/B = 12; for ApaI A/A = 53, A/a = 85, a/a = 22 and A/A = 27, A/a = 38, a/a = 15; for TaqI T/T = 44, T/t = 88, t/t = 28 and T/T = 32, T/t = 38, t/t = 10. Carriage of the b/b genotype of BsmI and the T/T genotype of TaqI was signif icantly associated with HCC (45/160 vs 33/80, P < 0.05 and 44/160 vs 32/80, P < 0.05, respectively). The absence of the A-T-C protective allele of BAT was signif i-cantly associated with the presence of HCC (46/80 vs 68/160, P < 0.05). A strong association was observed between carriage of the BAT A-T-C and G-T-T haplotypes and HCC only in alcoholic liver disease (7/46 vs 12/36 vs 11/21, P < 0.002, respectively).CONCLUSION: VDR genetic polymorphisms are sig-nificantly associated with the occurrence of HCC in patients with liver cirrhosis. This relationship is more specific for patients with an alcoholic etiology. | Edmondo Falleti Davide Bitetto Carlo Fabris Annarosa Cussigh Elisabetta Fontanini Ezio Fornasiere Elisa Fumolo Sara Bignulin Sara Cmet Rosalba Minisini Mario Pirisi Pierluigi Toniutto | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | Portal vein thrombosis in hepatocellular carcinoma: age and sex distribution in an autopsy study显示文摘 | Mario Pirisi Claudio Avellini Carlo Fabris Cathryn Scott Paola Bardus Giorgio Soardo Carlo A. Beltrami Ettore Bartoli | 1998 | Journal of Cancer Research and Clinical Oncology1998，，： | 2 |
| 3 | Recipient Interleukin-28B Rs12979860 C/T Polymorphism and Acute Cellular Rejection After Liver Transplantation: Role of the Calcineurin Inhibitor Used显示文摘 | Davide Bitetto Carlo Fabris Edmondo Falleti Ezio Fornasiere Claudio Avellini Sara Cmet Annarosa Cussigh Elisabetta Fontanini Mario Pirisi Stefano Ginanni Corradini Manuela Merli Antonio Molinaro Pierluigi Toniutto | 2012 | Transplantation Journal2012，，10： | 2 |
| 4 | Antiviral treatment of hepatitis C显示文摘 | TONIUTYO P FABRIS C PIRISI M | 2006 | Expert Opin Pharmacother2006，7，15： | 1 |
| 5 | Antiviral treatment of hepatitis C 显示文摘 | Toniutto P Fabris C Pirisi M | 2006 | Expert Opin Pharmacother2006，7，15： | 1 |
| 6 | Effects of sheep αs1- casein CC,CD and DD genotypes on milk composition and cheese making properties 显示文摘 | Pirisi A Piredda G Papoff C M | 1999 | Dairy Res1999，66，3： | 1 |
| 7 | Behavior of acylanilide and dicarboximidic fungicide residues on greenhouse tomatoes 显示文摘 | Cabras P M Meloni F M Pirisi and F Cabitza | 1985 | J Agric Food Chem1985，30，： | 1 |
| 8 | Basic and incentive payments for goatand sheep milk in relation to quality显示文摘 | A Pirisi A Lauret J P Dubeuf | 2007 | Small Ruminant Researc2007，68，： | 1 |
| 9 | Degradation of dicarboximidic fungicides in wine 显示文摘 | Cabras P M Meloni F M Pirisi and R Pirisi | 1984 | Pestic Sci1984，15，： | 1 |
| 10 | Antiviral treatment of hepatitis C 显示文摘 | TONIUTTO P FABRIS C PIRISI M | 2006 | Expert Opin Pharmacother2006，7，15： | 1 |
| 11 | Deficient antithrombin Ⅲ activity and enhanced fibrinolysis in patients with liver disease:evidence against a cause-effect relationship显示文摘 | Pirisi M Fabris C Ceriello A | 1995 | Acta Gastroenterol Belg1995，58，2： | 1 |
| 12 | Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA显示文摘 | PIRISI L YASUMOTO S FELLER M | 1987 | J Virol1987，61，： | 1 |
| 13 | Antiviral treatment of hepatitis C显示文摘 | Toniutto P Fabris C Pirisi M | 2006 | Expert Opinion on Pharmacotherapy2006，7，15： | 1 |
| 14 | Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA显示文摘 | PIRISI L YASUMOTO S FELLER M | 1987 | J Virol1987，61，4： | 1 |
| 15 | Simplified multiresidue method for the determination of organophosphorus insecticides in olive oil显示文摘 | CABRAS P ANGIONI A MELIS M MINELLI E V PIRISI F M | 1997 | Journal of Chromatography A1997，761，12： | 1 |
| 16 | Tissue biomarkers of prognostic significance in hepatocellular carcinoma显示文摘 | Pinato DJ Pirisi M Maslen L | 2014 | Adv Anat Pathol2014，21，4： | 1 |
| 17 | Antiviral treatment of hepatitis C 显示文摘 | TONIUTTO P FABRIS C PIRISI M | 2006 | Expert Opin Pharmaeother2006，7，15： | 1 |
| 18 | Multidetector-row CT angiography in the study of atherosclerotic carotid arteries显示文摘 | Saba L Sanfilippo R Pirisi R | 2007 | Neuroradiology2007，49，8： | 1 |
| 19 | LC/DAD/ESI/MS method for the determination of imidacloprid, thiacloprid, and spinosad in olives and olive oil after field treatment显示文摘 | ANGIONI A PORCU L PIRISI F | 2011 | Joumal of Agricultural and Food Chemistry2011，59，11： | 1 |
| 20 | Granulocytic sarcoma of the skin显示文摘 | Pirisi M Krengli M Valente G | 2008 | CMAJ2008，179，7： | 1 |
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