|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Ultrafast photonic PCR显示文摘Nucleic acid amplification and quantification via polymerase chain reaction(PCR)is one of the most sensitive and powerful tools for clinical laboratories,precision medicine,personalized medicine,agricultural science,forensic science and environmental science.Ultrafast multiplex PCR,characterized by low power consumption,compact size and simple operation,is ideal for timely diagnosis at the point-of-care(POC).Although several fast/ultrafast PCR methods have been proposed,the use of a simple and robust PCR thermal cycler remains challenging for POC testing.Here,we present an ultrafast photonic PCR method using plasmonic photothermal light-to-heat conversion via photon–electron–phonon coupling.We demonstrate an efficient photonic heat converter using a thin gold(Au)film due to its plasmon-assisted high optical absorption(approximately 65%at 450 nm,the peak wavelength of heat source light-emitting diodes(LEDs)).The plasmon-excited Au film is capable of rapidly heating the surrounding solution to over 150℃ within 3 min.Using this method,ultrafast thermal cycling(30 cycles;heating and cooling rate of 12.7960.93℃ s^(-1) and 6.660.29℃ s^(-1),respectively)from 55℃(temperature of annealing)to 95℃(temperature of denaturation)is accomplished within 5 min.Using photonic PCR thermal cycles,we demonstrate here successful nucleic acid(λ-DNA)amplification.Our simple,robust and low cost approach to ultrafast PCR using an efficient photonic-based heating procedure could be generally integrated into a variety of devices or procedures,including on-chip thermal lysis and heating for isothermal amplifications. | Jun Ho Son Byungrae Cho SoonGweon Hong Sang Hun Lee Ori Hoxha Amanda J Haack Luke P Lee | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 3 | Measurement of gaseous and aqueous trace formaldehyde:Revisiting the pentanedione reaction and field applications显示文摘 | Li J Dasgupta P K Luke W | 2005 | Anal Chim Acta2005，531，： | 1 |
| 4 | Simultaneous Estimation of Super-resolved Depth and All-in-focus Images from a Plenoptic Camera显示文摘 | Perez Nava F LUke J P | 2009 | IEEE2009，978，1： | 1 |
| 5 | Strategic hospital alli-ances:do the type and market structure of strategic hospital alli-ances matter?显示文摘 | MCCUE M J CLEMENT J P LUKE R D | 1999 | Medical care1999，37，10： | 1 |
| 6 | Prospective evaluation of mediastinoscopy for assessment of carcinoma of the lung 显示文摘 | Luke W P Pearson F G Todd R J | 1986 | J Thorac Cardiovasc Surg1986，91，： | 1 |
| 7 | Prolongation of allograft survival by administration of anti-CD45RB monoclonal antibody is due to alteration of CD45RBhi:CD45RBlo T-cell proportions显示文摘 | Luke P P W Deng J P Lian D | | 0，，09： | 1 |
| 8 | Diagnosis and treatment of superior mesenteric artery syndrome 显示文摘 | Gustafsson L Falk A Lukes P J | 1984 | Br J Surg1984，71，7： | 1 |
| 9 | Modern air craft hangars: A review of the design trends显示文摘 | LUKE STEVEN J HOWSON W P | 2002 | Structural Engineer2002，80，15： | 1 |
| 10 | Inhibition of 2A-mediated ' cleavage' of certain artificial polyproteins bearing Nterminal signal sequences显示文摘 | de Felipe P Luke G A Brown J D | | 0，，02： | 1 |
| 11 | Improved identification of volcanic features using Landsat 7 ETM+显示文摘 | Luke P F Andrew J L H Robert W | 2001 | Remote Sensing of Environment2001，78，12： | 1 |
| 12 | Alteration in CD45RBhi/CD45RBlo T-cell ratio following CD45RB monoclonal-antibody therapy occurs by selective deletion of CD45RBhi effector cells显示文摘 | Luke P P W Deng J P O'Brien C A | | 0，，02： | 1 |
| 13 | Overview of the epidemiol- ogy and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance显示文摘 | Luke F C Deveriek J A David L P | 2012 | Infection and Drug Resistance2012，5，： | 1 |
| 14 | Measurement of gaseous and aqueous trace formaldehyde: Revisiting the pentanedione reaction and field applications 显示文摘 | Li J Dasgupta P K Luke W | 2005 | AnalyticaChimicaActa2005，531，1： | 1 |
| 15 | Intravascular imaging tools in the cardiac catheterization laboratory: comprehensive as- sessment of anatomy and physiology 显示文摘 | Eshtehardi P Luke J MeDaniel MC | 2011 | J Cardiovasc Transl Res2011，4，4： | 1 |
| 16 | True-triaxial apparatus for simulation of hydraulically fractured multi-borehole hot dry rock reservoirs显示文摘 | FRASH LUKE P GUTIERREZ M HAMPTON J | 2014 | International Journal of Rock Mechanics and Mining Sciences2014，70，： | 1 |
| 17 | Richardson Skeletal muscle oxidative metabolism in sedentary humans:31P MRS assessment of O2 supply and demand limitations显示文摘 | Luke J Haseler Alexander P Lin Russell S | 2004 | J Appl Physiol2004，97，： | 1 |
| 18 | Evaluation of CCHP systems performance based on operational cost,primary energy consumption,and carbon dioxide emission by utilizing an optimal operation scheme显示文摘 | Cho H J Mago P J Luke R | | 0，，12： | 1 |
| 19 | Examining ssociation between cigarette smoking and colorectal cancer using historical case-control data显示文摘 | Luke J P Andrew H Kirsten B M | 2009 | Cancer Epidemiol2009，33，34： | 1 |
| 20 | Electron trapping nonuniformity in high-pressure-Bridg- man-grown CdZnTe显示文摘 | AMMAN M LEE J S LUKE P N | 2002 | J Appl Phys2002，92，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员