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| 1 | Digital detection, control,and distribution system for co-phase traction power supply application显示文摘 | SHU Ze-liang XIE Shao-feng LUKe | 2013 | IEEE Transaction on Industrial Elec- tronics2013，60，5： | 1 |
| 2 | Molecular cytogenetic map visualizes the heterozygotic genome and identifies translocation chromosomes in Citrus sinensis显示文摘Citrus sinensis is the most cultivated and economically valuable Citrus species in the world,whose genome has been assembled by three generation sequencings.However,chromosome recognition remains a problem due to the small size of chromosomes,and difficulty in differentiating between pseudo and real chromosomes because of a highly heterozygous genome.Here,we employ fluorescence in situ hybridization(FISH)with 9 chromosome painting probes,30 oligo pools,and 8 repetitive sequences to visualize 18 chromosomes.Then,we develop an approach to identify each chromosome in one cell through single experiment of oligo-FISH and Chromoycin A3(CMA)staining.By this approach,we construct a high-resolution molecular cytogenetic map containing the physical positions of CMA banding and 38 sequences of FISH including centromere regions,which enables us to visualize significant differences between homologous chromosomes.Based on the map,we locate several highly repetitive sequences on chromosomes and estimate sizes and copy numbers of each site.In particular,we discover the translocation regions of chromosomes 4 and 9 in C.sinensis“Valencia.”The high-resolution molecular cytogenetic map will help improve understanding of sweet orange genome assembly and also provide a fundamental reference for investigating chromosome evolution and chromosome engineering for genetic improvement in Citrus. | Shipeng Song Hui Liu Luke Miao Li He Wenzhao Xie Hong Lan Changxiu Yu Wenkai Yan Yufeng Wu Xiao-peng Wen Qiang Xu Xiuxin Deng Chunli Chen | 2023 | Journal of Genetics and Genomics2023，50，6： | 0 |
| 3 | Global burden and drivers of hyperglycemia:Estimates and predictions from 1990 to 2050显示文摘Hyperglycemia is a key risk factor for death and disability worldwide.To better inform prevention strategies,we aimed to delineate and predict the temporal,spatial,and demographic patterns in mean fasting plasma glucose(FPG)levels and their related disease burden globally.Based on the Global Burden of Disease Study 2019,we estimated the distributions of mean FPG levels and high FPG-related disease burden by age,sex,year,socioeconomic status(SES),and geographical region from 1990 to 2050. | Hui-Ling Qiu Shujun Fan Kaixin Zhou Zhini He Matthew H.E.M.Browning Luke D.Knibbs Tianyu Zhao Ya-Na Luo Xiao-Xuan Liu Li-Xin Hu Jia-Xin Li Yi-Dan Zhang Yu-Ting Xie Joachim Heinrich Guang-Hui Dong Bo-Yi Yang | 2023 | The Innovation2023，4，4： | 0 |
| 4 | TREM2依赖性小胶质细胞功能对于髓鞘再生及其神经保护至关重要显示文摘多发性硬化症(MS)的残疾在一定程度上是由髓鞘再生失败和进行性神经变性引起的。小胶质细胞和髓系细胞触发受体2(TREM2)(一种在小胶质细胞中高度表达的因子)已被证明在髓鞘再生中发挥重要作用。本研究使用大脑局灶性脱髓鞘模型,证明脱髓鞘在TREM2敲除小鼠中持续存在;脱髓鞘在注射溶血卵磷脂后持续超过6周,并导致严重的神经变性。我们还发现TREM2敲除小鼠在脱髓鞘后表现出神经胶质反应的改变。TREM2敲除小胶质细胞表现出迁移和吞噬髓磷脂碎片的缺陷。此外,来自携带人类疾病中普遍存在的TREM2突变的受试者的人类单核细胞衍生的巨噬细胞也显示出髓磷脂碎片吞噬作用的缺陷。综上所述,我们强调了TREM2信号在髓鞘再生和神经保护中的核心作用。这些发现揭示了慢性脱髓鞘如何导致轴突损伤,并有助于确定多发性硬化症的新型神经保护治疗靶点。 | YuanyuanWang Roxanne V Kyauk Yun-An A Shen Luke Xie Mike Reichelt Han Lin Zhiyu Jiang Hai Ngu Kimberle Shen Jacob J Greene Morgan Sheng Tracy J Yuen 杜一星(编译) | 2023 | 神经损伤与功能重建2023，18，7： | 0 |
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