|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Estrogen enhances the functions of CD4^(+)CD25^(+)Foxp3^(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro显示文摘Cross-talk has been shown to occur between the immune system and bone metabolism pathways.In the present study,we investigated the impact of CD4^(+)CD25^(+)Foxp3^(+) regulatory T(Treg)cells on osteoclastogenesis and bone resorption.Treg cells that were isolated and purified from peripheral blood mononuclear cells(PBMCs)of healthy adults inhibited both the differentiation of osteoclasts(OCs)from human embryo bone marrow cells(BMCs)and the pit formation in a dose-dependent manner.In cell cocultures,the production levels of both interleukin-10(IL-10)and transforming growth factor-beta 1(TGF-β1)were proportionally upregulated as the ratio of Treg cells to BMCs was increased,and the inhibition of OC differentiation and bone resorption by Treg cells was completely reversed by anti-IL-10 and anti-TGF-β1 antibodies.Treatment of BMC and Treg cell cocultures with 17β-estradiol(E2)at concentrations between 10^(-7) and 10^(-9) mol/l suppressed OC differentiation and bone resorption more efficiently than it did in cultures of BMCs alone;this enhanced suppression occurred via the stimulation of Treg cell IL-10 and TGF-b1 expression.These data suggest that Treg cells suppress OC differentiation and bone resorption by secreting IL-10 and TGF-β1.E2 enhances the suppressive effects of Treg cells on OC differentiation and bone resorption by stimulating IL-10 and TGF-β1 secretion from these cells.Therefore,Treg cell-derived IL-10 and TGF-b1 are likely involved in the regulation of E2 on bone metabolism and represent potential therapeutic targets for the treatment of postmenopausal osteoporosis(PMO). | CY Luo L Wang C Sun DJ Li | 2011 | Cellular & Molecular Immunology2011，8，1： | 33 |
| 2 | Design and Synthesis of DTPA-Folate for Use as a Tumor-Targeted Radiopharmaceutical显示文摘 | Wang S Luo DJ Lantrip DA | 1997 | Bioconjugate Chem1997，8，5： | 1 |
| 3 | Cycin D1 protein plays different roles in modulating chemoresponses in MCF7 and MDAMB231 cells显示文摘 | Sun Y Luo D Liao DJ | 2012 | J Carcinog2012，11，： | 1 |
| 4 | Quantitative analysis of perinatal rodent oligodendrocyte lineage progres- sion and its correlation with human 显示文摘 | Craig A Ling Luo N Beardsley DJ | 2003 | Exp Neurol2003，181，2： | 1 |
| 5 | Human prostate cancer and benign prostatic hyperplasia:molecular dissection by gene expression profiling显示文摘 | Luo J Duggan DJ Chen Y | 2001 | Cancer Res2001，61，： | 1 |
| 6 | Interobserver agreement andintraobserver reproducibility in thyroid ultrasound elastography显示文摘 | Lim DJ Luo S Kim MH | 2012 | AJR AmJ Roentgenol2012，198，4： | 1 |
| 7 | Quantitative ananysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human 显示文摘 | Craig A Ling Luo N Beardsley DJ etal | 2003 | Exp Neurol2003，181，2： | 1 |
| 8 | SYNTHESIS OF FULLERENE PYRROLIDINES CONTAINING SUBSTITUTED PHENYL GROUPS THROUGH AZOMETHINE YLIDE ADDITION显示文摘SYNTHESIS OF FULLERENE PYRROLIDINES CONTAINING SUBSTITUTED PHENYL GROUPS THROUGH AZOMETHINE YLIDE ADDITIONDeJianZHOU;LiangBin... | Zhou, DJ Gan, LB Tan, HS Luo, CP Huang, CH Pan, JQ Lu, MJ Wu, Y | 1995 | Chinese Chemical Letters1995，6，12： | 1 |
| 9 | Quantitative analysis of perinatalrodent oligodendrocyte lineage progression and its correlation with human显示文摘 | Craig A Luo ISL Beardsley DJ | 2003 | Exp Neurol2003，181，2： | 1 |
| 10 | Observation on blood glucose control efficacy of Biphasic insulin analogues and biphasic insulin on type 2 diabetic mellitus显示文摘 | WEI ZX HE DJ LUO LX | 2007 | J Nanhua Univ2007，35，6： | 1 |
| 11 | Quantitative ananysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human显示文摘 | Craig A Ling Luo N Beardsley DJ Wingate-Pearse N Walker DW Hohimer AR | 2003 | Exp Neurol2003，181，2： | 1 |
| 12 | The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals显示文摘 | Luo Z Shiojima I Bialik A Fulton D Lefer DJ Sessa WC | 2000 | Nat Med2000，6，9： | 1 |
| 13 | Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human 显示文摘 | Craig A Ling Luo N Beardsley DJ | 2003 | Exp Neurol2003，181，2： | 1 |
| 14 | Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with humane 显示文摘 | CraigA Luo NL Bearsley DJ | 2003 | Experimental Nourology2003，0181，2： | 1 |
| 15 | HIV-I subtype C in China 显示文摘 | Luo CC Tian C Hu DJ | 1995 | The Lancet1995，345，8956： | 1 |
| 16 | Spatial heterogeneity in oligodendrocyte lineage maturation and not cerebral blood flow predicts fetal ovine periventricular white matter injury显示文摘 | Riddle A Luo NL Manese M Beardsley DJ Green L Rorvik DA | 2006 | J Neurosci2006，26，11： | 1 |
| 17 | Human prostate cancer and benign prostatic hyperplasia: molecular dissection by gene expression profiling显示文摘 | Luo J Duggan DJ Chen Y | 2001 | Cancer Res2001，61，12： | 1 |
| 18 | Quantitative ananysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human显示文摘 | Craig A Luo NL Beardsley DJ | 2003 | p Neurol2003，181，2： | 1 |
| 19 | I-IIV -I subtype C in China显示文摘 | Luo CC Tian C Hu DJ | 1995 | Lan- cet1995，345，： | 1 |
| 20 | Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human显示文摘 | Craig A Luo NL Beardsley DJ | 2003 | Ep Neurol2003，181，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员