|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | A 2-V 900MHz Monolithic CMOS Dual-Loop Frequency Synthesizer for GSM Receivers显示文摘 | Yan W S T Luong H C | 2001 | IEEE J of Solid-State Circuit2001，36，2： | 1 |
| 3 | Quantitative chimeric analysis of six specificity determinants that differentiate Escherichia coli aspartate from tyrosine aminotransferase显示文摘 | Luong T N Rothman S C | 2002 | Protein Sci2002，，11： | 1 |
| 4 | Mgr, a novel global regulator in Staphylococcus aureus 显示文摘 | Luong T T Newell S W Lee C Y | 2003 | Baeteriol2003，185，13： | 1 |
| 5 | Use methanesulfonic acid as catalyst for the production linear alkylbenzenes显示文摘 | Luong B X Petre A L Hoelderich W F | 2004 | J Catal2004，226，： | 1 |
| 6 | Targeting amyloid-beta in glaucoma treatment 显示文摘 | Guo L Salt TE Luong V Wood N Cheung W Maass A | 2007 | Proc Natl Acad Sci U S A2007，104，13： | 1 |
| 7 | Iron sulphate roasting for extraction of lithium from lepidolite显示文摘 | LUONG V T DONG J K AN J W DAO D A KIM M J TRAN T | 2014 | Hydrometallurgy2014，141，： | 1 |
| 8 | Use of methanesulfonic acid as catalyst for the production of linearalkylbenzenes显示文摘 | Luong B X Petre A L Hoelderich W | 2004 | Journal of catalysis2004，226，2： | 1 |
| 9 | A 900MHz CMOS low-phase-noise voltage-controlled ring oscillator显示文摘 | YAN W S T LUONG H C | 2001 | IEEE Trans Circuits Syst Ⅱ2001，48，2： | 1 |
| 10 | Mgr, a novel global regulator in Staphylococcus aureus 显示文摘 | Luong T T Newell S W Lee C Y | 2003 | J Bacteriol2003，185，13： | 1 |
| 11 | Mgr a novel global regulator in Staphylococcus aureus 显示文摘 | Luong T T Newell S W Lee C Y | 2003 | J Bacteriol2003，185，： | 1 |
| 12 | Quantitative chimeric analysis of six specificity determinants that differentiate Escherichia coli aspartate from tyrosine aminotransferase 显示文摘 | Shaffer W A Luong T N Rothman S C | 2002 | Protein Sei2002，11，12： | 1 |
| 13 | Numerical and experimental analysis of aerostatic thrust bearings with porous restrictors显示文摘 | Luong T S Potze W | 2004 | Tribology International2004，37，10： | 1 |
| 14 | Mutational analysis of a nucleosidase involved in quorum-sensing autoinducer-2 biosynthesis显示文摘 | Lee J E Luong W Huang D J | 2005 | Biochemistry2005，44，11： | 1 |
| 15 | Use Methanesulfonic Acid as Catalyst for the Production Linear Alkylbenzenes显示文摘 | LUONG B X PETRE A L HOELDERICH W F | 2004 | J Cat2004，226，： | 1 |
| 16 | A 900MHz CMOS low-phase-noise voltage-controlled ring oscillator显示文摘 | YAN W S T LUONG H C | 2001 | IEEE Trans Circuits Syst II2001，48，2： | 1 |
| 17 | Numerical and Experimental Analysis of Aerostatic of Aerostatic Thrust Bearings with Porous Restrictors显示文摘 | Luong T S Potze W Post J B | 2004 | Tribology International2004，37，： | 1 |
| 18 | Enzyme or Protein Immobilization Techniques for Applications in Biosensor Design显示文摘 | SCOUTEN W H LUONG H T BROWN R S | 1995 | Tibtech1995，13，： | 1 |
| 19 | Numerical and Experimental Analysis of Aerostatic Thrust Bearings with Porous Restrictors 显示文摘 | Luong T S Potze W Post J B | 2004 | Tribology International2004，37，： | 1 |
| 20 | Numerical and experimental analysis of aerostatic of aerostatic thrust bearings with porous restrictors 显示文摘 | Luong T S Potze W Post J B | 2004 | Tribology International2004，37，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员