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| 1 | A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China显示文摘The coronavirus disease 2019(COVID-19)pandemic is a global crisis,and medical systems in many countries are overwhelmed with supply shortages and increasing demands to treat patients due to the surge in cases and severe illnesses.This study aimed to assess COVID-19-related essential clinical resource demands in China,based on different scenarios involving COVID-19 spreads and interventions.We used a susceptible–exposed–infectious–hospitalized/isolated–removed(SEIHR)transmission dynamics model to estimate the number of COVID-19 infections and hospitalizations with corresponding essential healthcare resources needed.We found that,under strict non-pharmaceutical interventions(NPIs)or mass vaccination of the population,China would be able to contain community transmission and local outbreaks rapidly.However,under scenarios involving a low intensity of implemented NPIs and a small proportion of the population vaccinated,the use of a peacetime–wartime transition model would be needed for medical source stockpiles and preparations to ensure a normal functioning healthcare system.The implementation of COVID-19 vaccines and NPIs in different periods can influence the transmission of COVID-19 and subsequently affect the demand for clinical diagnosis and treatment.An increased proportion of asymptomatic infections in simulations will not reduce the demand for medical resources;however,attention must be paid to the increasing difficulty in containing COVID-19 transmission due to asymptomatic cases.This study provides evidence for emergency preparations and the adjustment of prevention and control strategies during the COVID-19 pandemic.It also provides guidance for essential healthcare investment and resource allocation. | Ting Zhang Qing Wang Zhiwei Leng Yuan Yang Jin Yang Fangyuan Chen Mengmeng Jia Xingxing Zhang Weiran Qi Yunshao Xu Siya Chen Peixi Dai Libing Ma Luzhao Feng Weizhong Yang | 2021 | Engineering2021，7，7： | 7 |
| 2 | The Incoming Influenza Season—China,the United Kingdom,and the United States,2021–2022显示文摘Introduction:Seasonal influenza activity has declined globally since the widespread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)transmission.There has been scarce information to understand the future dynamics of influenza—and under different hypothesis on relaxation of nonpharmaceutical interventions(NPIs)in particular—after the disruptions to seasonal patterns.Methods:We collected data from public sources in China,the United Kingdom,and the United States,and forecasted the influenza dynamics in the incoming 2021–2022 season under different NPIs.We considered Northern China and Southern China separately,due to the sharp difference in the patterns of seasonal influenza.For the United Kingdom,data were collected for England only.Results:Compared to the epidemics in 2017–2019,longer and blunter influenza outbreaks could occur should NPIs be fully lifted,with percent positivity varying from 10.5 to 18.6 in the studying regions.The rebounds would be smaller if the maskwearing intervention continued or the international mobility stayed low,but sharper if the mask-wearing intervention was lifted in the middle of influenza season.Further,influenza activity could stay low under a much less stringent mask-wearing intervention coordinated with influenza vaccination.Conclusions:The results added to our understandings of future influenza dynamics after the global decline during the coronavirus disease 2019(COVID-19)pandemic.In light of the uncertainty on the incoming circulation strains and the relatively low negative impacts of mask wearing on society,our findings suggested that wearing mask could be considered as an accompanying mitigation measure in influenza prevention and control,especially for seasons after long periods of low-exposure to influenza viruses.Seasonal influenza activity declines globally during the coronavirus disease 2019(COVID-19)pandemic(1–4).For instance,in China,influenza activity,as measured by percentage of submitted specimens testing positive,dropped from 11.8%to 2.0%in 2020–2021 influenza season,compared to the past 5 years(5).The long-period of low-exposure to influenza viruses adds great uncertainty on preparedness for the incoming 2021–2022 influenza season.Influenza vaccination is one of the most effective measures in seasonal influenza prevention and control,but with only a few influenza viruses circulating,it could be difficult to determine the targeted strains for vaccination.In this context,it is of primary importance to identify alternative mitigation measures for the incoming 2021–2022 influenza season,the first season after long periods of virtually no influenza outbreaks worldwide.Using data from China,the United Kingdom,and the United States,we forecasted the influenza activity in the incoming 2021–2022 influenza season under hypothetical scenarios without non-pharmaceutical interventions(NPIs)and with different assumptions on mask-wearing and mobility levels. | Shasha Han Ting Zhang Yan Lyu Shengjie Lai Peixi Dai Jiandong Zheng Weizhong Yang Xiaohua Zhou Luzhao Feng | 2021 | China CDC weekly2021，3，49： | 3 |
| 3 | One Hundred Years of Influenza Since the 1918 Pandemic—Is China Prepared Today?显示文摘Almost 100 years after the 1918 influenza pandemic,China experienced its largest,most widespread epidemic of human infections with avian influenza A(H7N9),the influenza virus with the greatest pandemic potential of all influenza viruses assessed to date by the United States Centers for Disease Control and Prevention’s Influenza Risk Assessment Tool.This historical review describes how China was affected by the 1918,1958,1968,and 2009 influenza pandemics,records milestones in China’s capacity to detect and respond to influenza threats,and identifies remaining challenges for pandemic preparedness.This review suggests that past influenza pandemics have improved China’s national capabilities such that China has become a global leader in influenza detection and response.Further enhancing China’s pandemic preparedness to address remaining challenges requires government commitment and increased investment in China’s public health and healthcare systems. | Ran Zhang Xiaoping Dong Dayan Wang Luzhao Feng Lei Zhou Ruiqi Ren Carolyn Greene Ying Song Alexander J.Millman Eduardo Azziz-Baumgartner Zijian Feng | 2019 | China CDC weekly2019，1，4： | 2 |
| 4 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 5 | Association between influenza vaccination and SARS-CoV-2 infection and its outcomes: systematic review and meta-analysis显示文摘Background:World Health Organization recommends that influenza vaccines should benefit as much of the population as possible,especially where resources are limited.Corona virus disease 2019(COVID-19)has become one of the greatest threats to health systems worldwide.The present study aimed to extend the evidence of the association between influenza vaccination and COVID-19 to promote the former.Methods:In this systematic review,four electronic databases,including the Cochrane Library,PubMed,Embase,and Web of Science,were searched for related studies published up to May 2022.All odds ratios(ORs)with 95%confidence intervals(CIs)were pooled by meta-analysis.Results:A total of 36 studies,encompassing 55,996,841 subjects,were included in this study.The meta-analysis for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection provided an OR of 0.80(95%CI:0.73–0.87).The statistically significant estimates for clinical outcomes were 0.83(95%CI:0.72–0.96)for intensive care unit admission,0.69(95%CI:0.57–0.84)for ventilator support,and 0.69(95%CI:0.52–0.93)for fatal infection,while no effect seen in hospitalization with an OR of 0.87(95%CI:0.68–1.10).Conclusion:Influenza vaccination helps limit SARS-CoV-2 infection and severe outcomes,but further studies are needed.Registration:PROSPERO,CRD42022333747. | Binshan Jiang Qiangru Huang Mengmeng Jia Xinai Xue Qing Wang Weizhong Yang Luzhao Feng | 2022 | Chinese Medical Journal2022，135，19： | 1 |
| 6 | Increased Incidence of Scarlet Fever--China,1999−2018显示文摘What is already known about this topic?Scarlet fever had high incidence between the 1950s and 1980s,but during the 1980s and 1990s,the incidence of scarlet fever dropped to a relatively low and stable levels in China.What is added by this report?Starting in 2011,scarlet fever incidence significantly increased in China.In the eight years between 2011 and 2018,479,555 cases were reported,which exceeded the total number of 241,365 cases reported in the previous twelve years 1999–2010.What are the implications for public health practice?Both patient and pathogen epidemiological surveillance need to be heightened to monitor serious cases of scarlet fever and to implement timely control measures. | Yuanhai You Ying Qin Mark J.Walker Luzhao Feng Jianzhong Zhang | 2019 | China CDC weekly2019，1，5： | 1 |
| 7 | Decreased influenza vaccination coverage among Chinese healthcare workers during the COVID-19 pandemic显示文摘Background:Healthcare workers(HCWs)were the priority group for influenza vaccination,in China during the 2020/2021 and 2021/2022 influenza seasons.However,vaccination rates in HCWs have always been low.This study investigated influenza vaccination status among Chinese HCWs and analyzed the factors driving vaccination.Methods:We provided electronic questionnaires to HCWs from January 27,2022 to February 21,2022,using the WeChat platform'Breath Circles'.HCWs who received the link could also forward it to their colleagues.Binary logistic regression models were used to analyze vaccination-associated factors among HCWs.Results:Among the 1697 HCWs surveyed,vaccination coverage was 43.7%(741/1697)during the 2020/2021 influenza season,and 35.4%(600/1697)during the 2021/2022 influenza season,as of February 21,2022.Additionally,22.7%(385/1697)and 22.1%(358/1697)of HCWs reported that their workplaces implemented a free vaccination policy for all employees during the 2020/2021 and 2021/2022 influenza seasons.HCWs who were required to be vaccinated according to hospital regulations,and whose hospitals implemented the free influenza vaccine policy were more likely to be vaccinated(2020/2021 and 2021/2022;P<0.05).In addition,the economic level of the HCWs'province(2021/2022,P<0.05)and the HCWs’knowledge about vaccination and willingness to get vaccinated,such as active learning about vaccines(2020/2021,P<0.05),supportive attitude toward vaccination for all HCWs(2020/2021 and 2021/2022;P<0.05),also had an impact on vaccine coverage.Conclusions:A free influenza vaccination policy and workplace required vaccination are effective in improving influenza vaccination coverage among HCWs.Influenza vaccination coverage of Chinese HCWs remained low and showed a downward trend after the COVID-19 outbreak.Further effective measures,such as advocacy campaigns,free vaccine policies,and on-site vaccination could be implemented to improve influenza vaccination coverage. | Libing Ma Xuan Han Yuan Ma Yuan Yang Yunshao Xu Di Liu Weizhong Yang Luzhao Feng | 2022 | Infectious Diseases of Poverty2022，11，5： | 1 |
| 8 | Attitudes Regarding Influenza Vaccination Among Public Health Workers during COVID-19 Pandemic — China, September 2022显示文摘Summary What is already known about this topic?Public health workers(PHWs)were listed as a priority group recommended for influenza vaccination during the coronavirus disease 2019(COVID-19)pandemic.Understanding the drivers of influenza vaccine hesitancy among PHWs can promote influenza vaccination in the COVID-19 pandemic. | Heya Yi Yanlin Cao Jiemi Zhao Binshan Jiang Congxuan Bing Zijian Feng Weizhong Yang Jiandong Zheng Luzhao Feng | 2023 | China CDC weekly2023，5，6： | 1 |
| 9 | 应急状态下新冠流行曲线预测的方法学研究——基于北京市百度搜索和传统流感样病例监测显示文摘Surveillance is an essential work on infectious diseases prevention and control.When the pandemic occurred,the inadequacy of traditional surveillance was exposed,but it also provided a valuable opportunity to explore new surveillance methods.This study aimed to estimate the transmission dynamics and epidemic curve of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)Omicron BF.7 in Beijing under the emergent situation using Baidu index and influenza-like illness(ILI)surveillance.A novel hybrid model(multiattention bidirectional gated recurrent unit(MABG)-susceptible-exposed-infected-removed(SEIR))was developed,which leveraged a deep learning algorithm(MABG)to scrutinize the past records of ILI occurrences and the Baidu index of diverse symptoms such as fever,pyrexia,cough,sore throat,anti-fever medicine,and runny nose.By considering the current Baidu index and the correlation between ILI cases and coronavirus disease 2019(COVID-19)cases,a transmission dynamics model(SEIR)was formulated to estimate the transmission dynamics and epidemic curve of SARS-Co V-2.During the COVID-19 pandemic,when conventional surveillance measures have been suspended temporarily,cases of ILI can serve as a useful indicator for estimating the epidemiological trends of COVID-19.In the specific case of Beijing,it has been ascertained that cumulative infection attack rate surpass 80.25%(95%confidence interval(95%CI):77.51%-82.99%)since December 17,2022,with the apex of the outbreak projected to transpire on December 12.The culmination of existing patients is expected to occur three days subsequent to this peak.Effective reproduction number(Rt)represents the average number of secondary infections generated from a single infected individual at a specific point in time during an epidemic,remained below 1 since December 17,2022.The traditional disease surveillance systems should be complemented with information from modern surveillance data such as online data sources with advanced technical support.Modern surveillance channels should be used primarily in emerging infectious and disease outbreaks.Syndrome surveillance on COVID-19 should be established to following on the epidemic,clinical severity,and medical resource demand. | Ting Zhang Liuyang Yang Xuan Han Guohui Fan Jie Qian Xuancheng Hu Shengjie Lai Zhongjie Li Zhimin Liu Luzhao Feng Weizhong Yang | 2023 | Engineering2023，31，12： | 0 |
| 10 | Experts’Consensus on the Management of Respiratory Disease Syndemic显示文摘The global burden of respiratory diseases is a significant and increasing threat to individuals worldwide.In 2017,there were 544.9 million cases of chronic respiratory diseases,a 39.8%increase since 1990(1).These diseases were the third leading cause of global mortality in 2017,accounting for 7.0%of all deaths,an 18.0%increase compared to 1990. | Weizhong Yang Zhongjie Li Ting Yang Yanming Li Zhengde Xie Luzhao Feng Zhibin Peng Jue Liu | 2024 | China CDC weekly2024，6，8： | 0 |
| 11 | City-Specific Effects of Lifting Mobility Restrictions—China, February–March 2020显示文摘Summary What is already known about this topic?Government used mobility restrictions to help contain the first wave of coronavirus disease 2019(COVID-19)across cities in China.The restrictions were lifted during times of non-zero incidence in response to a return to work order that went into effect on February 10,2020.What is added by this report?The effect of lifting mobility restrictions on COVID-19 death rate and incidence varied by city,with smaller increases or even reductions in cities with low community connectivity and small floating volume,and larger increases in cities with high community connectivity and large floating volume.Effects on recovery rates were similar across cities.What are the implications for public health practice?City-specific mobility restriction lifting is likely to be beneficial.Two indexes,community connectivity and floating volume,can inform the design of city-specific mobility restriction lifting policies. | Shasha Han Libing Ma Ting Zhang Luzhao Feng Weizhong Yang Xiaoying Zheng | 2022 | China CDC weekly2022，4，31： | 0 |
| 12 | Long-term outcomes in COVID-19 patients who recovered from the first wave of the pandemic显示文摘This cross-sectional study evaluated the long-term health effects of coronavirus disease 2019(COVID-19)in Jianghan District(Wuhan,China).The results showed that 61.4%of COVID-19 patients reported at least one symptom and 8.8%had depressive symptoms at the 17-month follow-up.The proportion of patients with chest radiographic abnormalities in Fangcang shelter hospitals and designated COVID-19hospitals was 31.6%and 41.1%,respectively,and the proportion of patients with impaired pulmonary diffusion capacity in these hospitals was 52.8%and 60.9%,respectively.Female sex(odds ratio[OR]=1.48,95%confidence interval[CI]:1.16–1.88),severe disease(OR=1.46,95%CI:1.01–2.10)and a higher number of initial symptoms(OR=1.31,95%CI:1.23–1.40)were associated with the development of sequelae symptoms at 17 months.This study involving community-dwelling COVID-19adults may help determine the long-term effects of COVID-19 during the first pandemic wave.Nonetheless,larger follow-up studies are needed to characterize the post-COVID-19 condition. | Dan Cui Simiao Chen Luzhao Feng Mengmeng Jia Yeming Wang Weijun Xiao Yanxia Sun Qiangru Huang Libing Ma Zhiwei Leng Hao Wang Bin Cao Weizhong Yang Juntao Yang Chen Wang | 2022 | National Science Review2022，9，11： | 0 |
| 13 | Willingness of Caregivers to Have Their Children Vaccinated with Pneumococcal Vaccines in the Context of an Innovative Immunization Strategy—Weifang City,Shandong Province,2021显示文摘Summary What is already known about this topic?Pneumococcal diseases(PDs)pose a serious health threat to children.Vaccination is the most costeffective intervention to prevent PDs,but pneumococcal vaccines coverage among children is low in China.What is added by this report?This study investigated the willingness of children’s caregivers to have their children vaccinated with pneumococcal vaccines under an innovative policy to offer 1-dose of the 13-valent pneumococcal conjugate vaccines at no charge to families.The research found that 70.51%of caregivers were willing to have their infants receive pneumococcal vaccines and that reducing the cost of vaccines may increase caregivers’willingness.What are the implications for public health practice?This is the first evaluation in China of acceptance of pneumococcal vaccines among children under a 1-dose,cost-free policy.The results provide scientific evidence for updating local and national pneumococcal immunization strategies to promote the use of the pneumococcal vaccine. | Yuan Yang Ting Zhang Yan Wang Libing Ma Shuyun Xie Jian Zhou Weiran Qi Qing Wang Peixi Dai Yuanze Du Luzhao Feng Chunping Wang Weizhong Yang | 2022 | China CDC weekly2022，4，20： | 0 |
| 14 | Quantitative Analysis of the Effectiveness of Antigen-and Polymerase Chain Reaction-Based Combination Strategies for Containing COVID-19 Transmission in a Simulated Community显示文摘The number of coronavirus disease 2019(COVID-19)cases continues to surge,overwhelming healthcare systems and causing excess mortality in many countries.Testing of infectious populations remains a key strategy to contain the COVID-19 outbreak,delay the exponential spread of the disease,and flatten the epidemic curve.Using the Omicron variant outbreak as a background,this study aimed to evaluate the effectiveness of testing strategies with different test combinations and frequencies,analyze the factors associated with testing effectiveness,and optimize testing strategies based on these influencing factors.We developed a stochastic,agent-based,discrete-time susceptible–latent–infectious–recovered model simulating a community to estimate the association between three levels of testing strategies and COVID-19 transmission.Antigen testing and its combination strategies were more efficient than polymerase chain reaction(PCR)-related strategies.Antigen testing also showed better performance in reducing the demand for hospital beds and intensive care unit beds.The delay in the turnaround time of test results had a more significant impact on the efficiency of the testing strategy compared to the detection limit of viral load and detection-related contacts.The main advantage of antigen testing strategies is the short turnaround time,which is also a critical factor to be optimized to improve PCR strategies.After modifying the turnaround time,the strategies with less frequent testing were comparable to daily testing.The choice of testing strategy requires consideration of containment goals,test efficacy,community prevalence,and economic factors.This study provides evidence for the selection and optimization of testing strategies in the post-pandemic era and provides guidance for optimizing healthcare resources. | Qiangru Huang Yanxia Sun Mengmeng Jia Ting Zhang Fangyuan Chen Mingyue Jiang Qing Wang Luzhao Feng Weizhong Yang | 2023 | Engineering2023，，9： | 0 |
| 15 | Long-Term Patterns of Meningitis Mortality:A Continual Downward Trend and a Vulnerable Infant Population—China,1987–2021显示文摘Summary What is already known about this topic?Meningitis,a life-threatening disease,presents a significant public health challenge.Its rate of progress in burden reduction notably lags behind other diseases that can be prevented through vaccination.What is added by this report?This research explored the changes in the mortality rate of meningitis in China over a span of 35 years.The study further identified the effects of age,period,and cohort on the mortality trends. | Yu Wu Huiyun Fan Binbin Su Chao Guo Luzhao Feng | 2023 | China CDC weekly2023，5，34： | 0 |
| 16 | Epidemiological Shifts in Infectious Diseases in China:Implications and Policy Recommendations显示文摘In recent decades,China has experienced significant alterations in its landscape of infectious diseases,with noteworthy reductions in historically prevalent illnesses such as tuberculosis and viral hepatitis.At the same time,emerging pathogens like severe acute respiratory syndrome(SARS),Influenza A virus subtype H7N9(H7N9),and SARS coronavirus 2(SARS-CoV-2)pose new challenges.These epidemiological shifts,fueled by fast economic development,urbanization,modifications in the healthcare system,and an aging population,present considerable obstacles to the country’s public health infrastructure and policy frameworks.This article provides a comprehensive review of these changes,underscoring the driving forces behind them and the resultant impact on health policy and infrastructure.It stresses the challenges and calls for an intensification of surveillance efforts,the establishment of collaborative partnerships both nationally and internationally,the encouragement of worldwide cooperation,and the reinforcement of public health education as pivotal strategies for managing China’s changing spectrum of infectious diseases. | Binbin Su Zuliyaer Talifu Luzhao Feng | 2023 | China CDC weekly2023，5，42： | 0 |
| 17 | Factors Associated with PCV13 Vaccine Hesitancy in Parents under an Innovative Immunization Strategy:a Cross-Sectional Study—Weifang City,Shandong Province,China,2021显示文摘Summary What is already known on this topic?Pneumococcal diseases(PDs)are serious threats to child health.Although vaccination is one of the most effective ways to prevent these diseases,the pneumococcal vaccination coverage rate is still relatively low in China.What is added by this report?This study investigated the factors associated with 13-valent pneumococcal conjugate vaccine(PCV13)vaccine hesitancy in parents under an innovative immunization strategy. | Yuanze Du Yan Wang Ting Zhang Libing Ma Shuyun Xie Yi Wang Yuan Yang Juanjuan Li Yushu Feng Yujue Wang Weiran Qi Weizhong Yang Jian Zhou Chunping Wang Luzhao Feng | 2023 | China CDC weekly2023，5，12： | 0 |
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