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| 1 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 2 | New serological markers in pediatric patients with inflammatory bowel disease显示文摘The spectrum of serological markers associated with inflammatory bowel disease(IBD)is rapidly growing.Due to frequently delayed or missed diagnoses,the application of non-invasive diagnostic tests for IBD,as well as differentiation between ulcerative colitis(UC)and Crohn’s disease(CD),would be useful in the pediatric population.In addition,the combination of pancreatic autoantibodies and antibodies against Saccharomyces cerevisiae antibodies/perinuclear cytoplasmic antibody(pANCA)improved the sensitivity of serological markers in pediatric patients with CD and UC.Some studies suggested that age-associated differences in the patterns of antibodies may be present,particularly in the youngest children.In CD,most patients develop stricturing or perforating complications,and a significant numberof patients undergo surgery during the disease course.Based on recent knowledge,serum antibodies are qualitatively and quantitatively associated with complicated CD behavior and CD-related surgery.Pediatric UC is characterized by extensive colitis and a high rate of colectomy.In patients with UC,high levels of antiCBir1 and pANCA are associated with the development of pouchitis after ileal pouch-anal anastomosis.Thus,serologic markers for IBD can be applied to stratify IBD patients into more homogeneous subgroups with respect to disease progression.In conclusion,identification of patients at an increased risk of rapid disease progression is of great interest,as the application of early and more aggressive pharmaceutical intervention could have the potential to alter the natural history of IBD,and reduce complications and hospitalizations. | Márta Kovács Katalin Eszter Müller Mária Papp Péter László Lakatos Mihály Cs?ndes Gábor Veres | 2014 | World Journal of Gastroenterology2014，20，17： | 4 |
| 3 | Modulation of long- term memory for object recognition via HDAC inhibition 显示文摘 | STEFANKO D P BARRETT R M LY A R | 2009 | Proc Nail Acad Sci U S A2009，106，23： | 1 |
| 4 | 查看详情显示文摘 | László P Juan F G R Péter F Attila G Mihály D László A Bienvenida G Antonio M | | 0，，03： | 1 |
| 5 | Human kallikrein 10; a novel tumor marker for ovarian carcinoma? 显示文摘 | Luo LY Bunting P Scorilas A | 2001 | Clin Chim Arta2001，306，12： | 1 |
| 6 | Huntingtin-interacting pro-tein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles 显示文摘 | Ohyama T Verstreken P Ly C V | 2007 | J Cell Biol2007，179，7： | 1 |
| 7 | United States of America: Health system review显示文摘 | RICE T ROSENAU P UNRUH LY | 2013 | Health Systems in Transition2013，15，3： | 1 |
| 8 | Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology,and induces cell transformatlon显示文摘 | Zeng LY Sachdev P Yan L | 2000 | Mol Cell Biol2000，20，24： | 1 |
| 9 | Endobronehial ultrasound- guided transbronchial needle aspiration fur staging of lung cancer: A systematic review and meta-analysis显示文摘 | Gu P Zhao YZ Jiang LY | 2009 | Eur J Cancer2009，45，： | 1 |
| 10 | /~ieprin alpha metalloproteases enhance iipopolysaccharide - stimulated production of tumour necrosis factor -alpha and interleukin - 1 beta in peripheral blood mononuclear cells via activation of NF - kappaB 显示文摘 | Gao 'P Si LY | 2010 | Regulatory Peptides2010，160，13： | 1 |
| 11 | Endobronchial ultrasound-guided transbronchial needle aspiration for staging of lung cancer: a sys- tematic review and meta-analysis 显示文摘 | Gu P Zhao YZ Jiang LY | 2009 | Eur J Cancer2009，45，： | 1 |
| 12 | Localised plasmacytomas in Taiwan: comparison between extramedullary plasmacytoma and solitary plasmacytoma of bone 显示文摘 | Shih LY Dunn P Leung WM | 1995 | Br J Cancer1995，71，1： | 1 |
| 13 | Retinoic acid syndrome in patients following the treatment of acute promyelocytic leukemia with all-trans retinoic acid 显示文摘 | Su YC Dunn P Shih LY | 2009 | Chang Gung Med J2009，32，5： | 1 |
| 14 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 15 | Gefitinib or piacebo in com- bination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: a randomized phase Ⅱ study 显示文摘 | Osborne CK Neven P Dirix LY | 2011 | Clin Cancer Res2011，17，5： | 1 |
| 16 | Netrin-1 in- hibits leukocyte migration in vitro and in vivo 显示文摘 | LY N P KOMATSUZAKI K FRASER ! P | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 17 | Sequential DNA methy-lation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differ-enttiation 显示文摘 | Deb-Rinker P Ly D Jezierski A | 2005 | J Biol Chem2005，280，8： | 1 |
| 18 | strain S33显示文摘 | Wang S N Liu Z Xu P Biodegradation of nicotine by a new- ly isolated Agrobacterium sp | 2009 | J Appl Microbi- ol2009，107，3： | 1 |
| 19 | Synergistic anti- microbial activity between pentacyelic triterpenoids and antibiotics against Staphylococcus aureus strains显示文摘 | CHUNG PY NAVARATNAM P CHUNG LY | 2011 | Ann Clin Microbiol An-timicrob2011，10，： | 1 |
| 20 | Synaptic mitochondria are critical form obilization of reserve pool vesicles at Dro-sophila neuromuscular junctions显示文摘 | Verstreken P Ly CV Venken | | 0，，7： | 1 |
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