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| 1 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 2 | Cystic lymphangioma of the pancreas显示文摘Lymphangioma of the pancreas is an extremely rare benign tumour of lymphatic origin,with fewer than 60 published cases. Histologically,it is polycystic,with the cysts separated by thin septa and lined with endothelial cells. Though congenital,it can affect all age groups,and occurs more frequently in females. Patients usually present with epigastric pain and an associated palpable mass. Complete excision is curative,even though,depending on the tumour location,surgery may be simple or involve extensive pancreatic resection and anastomoses. The authors present a 49-year-old woman in whom a polycystic septated mass,35 mm x 35 mm in size,was discovered by ultrasonography (US) in the body of the pancreas during investigations for epigastric pain and nausea. At surgery,a well circumscribed polycystic tumor was completely excised,with preservation of the pancreatic duct. The postoperative recovery was uneventful. Histology confirmed a microcystic lymphangioma of the pancreas. Immunohistochemistry showed cystic endothelial cells reactivity to factor Ⅷ -RA (++),CD31 (+++) and CD34 (-). Postoperatively,abdominal pain disappeared and the patient remained symptomfree for 12 mo until now. Although extremely rare,lymphangioma of the pancreas should be taken into consideration as a differential diagnosis of a pancreatic cystic lesion,especially in women. | Radoje B Colovic Nikica M Grubor Marjan T Micev Henry Dushan E Atkinson Vitomir I Rankovic Mihajlo M Jagodic | 2008 | World Journal of Gastroenterology2008，14，44： | 6 |
| 3 | Perigastric extraskeletal Ewing's sarcoma: A case report显示文摘Ewing's sarcoma (ES) is a neoplasm of undifferentiated small round cells, which occurs in the bones and deep soft tissues of children and adolescents. We present a rare case of a 44-year-old woman with gastric ES presenting with epigastric pain and weight loss. Ultrasound and computed tomography scans indicated a solid/cystic mass in the pancreatic tail. At laparotomy, the tumor was found attached to the posterior surface of the stomach, completely free from the pancreas, with no lymphadenopathy or local metastases. The polynodal, partly pseudocystic, dark-red soft tumor was excised. Histopathology revealed an anaplastic small-round-cell tumor with strong membranous CD99 immunoexpression. Additionally, there was patchy immunostaining for S-100 protein, vimentin, protein gene product (PGP) 9.5 and neuron-specifi c enolase, and weak focal CD117 cytoplasmic immunoreactivity. The patient had no adjuvant chemotherapy; her postoperative recovery was uneventful, and she remains symptom-free, and without any sign of recurrence at 20 mo. To the best of our knowledge, this is only the third ever case of gastric ES. | Radoje B Colovic Nikica M Grubor Marjan T Micev Slavko V Matic Henry Dushan Edward Atkinson Stojan M Latincic | 2009 | World Journal of Gastroenterology2009，15，2： | 2 |
| 4 | Two synchronous somatostatinomas of the duodenum and pancreatic head in one patient显示文摘Somatostatinomas are extremely rare neuroendocrine tumors of the gastrointestinal tract,f irst described in the pancreas in 1977 and in the duodenum in 1979.They may be functional and cause somatostatinoma or inhibi-tory syndrome,but more frequently are non-functioning pancreatic endocrine tumors that produce somatostatin alone.They are usually single,malignant,large lesions,frequently associated with metastases,and generally with poor prognosis.We present the unique case of a 57-year-old woman with two synchronous non-function-ing somatostatinomas,one solid duodenal lesion and one cystic lesion within the head of the pancreas,that were successfully resected with a pylorus-preserving Whipple's procedure.No secondaries were found in the liver,or in any of the removed regional lymph nodes.The patient had an uneventful recovery,and remains well and symptom-free at 18 mo postoperatively.This is an extremely rare case of a patient with two synchro-nous somatostatinomas of the duodenum and the pancreas.The condition is discussed with reference to the literature. | Radoje B olovi Slavko V Mati Marjan T Micev Nikica M Grubor Henry Dushan Atkinson Stojan M Latini | 2009 | World Journal of Gastroenterology2009，15，46： | 1 |
| 5 | Total antioxidant activity and phenolic content in selected vegetables显示文摘 | Amin Ismail Zamaliah M Marjan Chin W Foong | 2004 | Food Chemistry2004，，4： | 1 |
| 6 | Vitamin C and vitamin E supplementation reduce oxidative stress–induced embryo toxicity and improve the blastocyst development rate显示文摘 | Xia Wang Tommaso Falcone Marjan Attaran Jeffrey M Goldberg Ashok Agarwal Rakesh K Sharma | 2002 | Fertility and Sterility2002，，6： | 1 |
| 7 | Total antioxidant activity and phenolic content in selected vegetables显示文摘 | Ismail A Marjan Z M Foong C W | 2004 | Food Chemistry2004，87，： | 1 |
| 8 | Effect of simvastatin on renal function in autosomal dominat polycystic kidney disease 显示文摘 | Marjan A Van D Adriaan M | 2001 | Nephrol Dial Transplant2001，16，： | 1 |
| 9 | Localization of lipoxy- genases 1 and 2 in germinating soybean seeds by an indirect immunofluorescence technique 显示文摘 | Marjan Vernooy-Gerritsen Adri L M Bos Gerrit A Veldink Johannes F G Vliegenthart | 1983 | Techni Plant Physiol1983，73，2： | 1 |
| 10 | Total antioxidant activity and phenolic content in selected vegetables 显示文摘 | Amin Ismail Zamaliah M Marjan Chin W Foong | 2004 | Food Chemistry2004，87，： | 1 |
| 11 | Release behavior and intra-articular biocompatibility of celecoxib-loaded acetyl-capped PCLA-PEG-PCLA thermogels显示文摘 | Audrey Petit Marjan Sandker Benno Müller Ronald Meyboom Paul van Midwoud Peter Bruin Everaldo M. Redout Marjan Versluijs-Helder Chris H.A. van der Lest Sytze J. Buwalda Leo G.J. de Leede Tina Vermonden Robbert Jan Kok Harrie Weinans Wim E. Hennink | 2014 | Biomaterials2014，，： | 1 |
| 12 | Total antioxidant activity and phenolic content in selected vegetables 显示文摘 | Ismail A Marjan Z M Foong C W | 2004 | Food Chemistry2004，87，： | 1 |
| 13 | When and how to develop Domain Specific Languages 显示文摘 | M Marjan H Jan M S Anthony | 2005 | ACM Computing Surveys2005，37，： | 1 |
| 14 | Intermolecular Interactions and Dynamics in Polymer/C60 Blends 显示文摘 | Peter A M Marjan L | 2010 | Macromolecules2010，，43： | 1 |
| 15 | Product design planning with the analytic hierarchy process in inter -organizational networks 显示文摘 | Marjan J M van Rossum H W | 2002 | R&D Management2002，，： | 1 |
| 16 | Exploration and exploitation in evolutionary algorithms: a survey 显示文摘 | Matej C Shin H L Marjan M | 2013 | ACM Computing Surveys2013，45，3： | 1 |
| 17 | Foley catheter versus vaginal prostaglandin E2 gel for induction of labour at term ( PROBAAT trial) : an open- label, randomised controlled trial 显示文摘 | JOZWIAK M OUDE RENGERINK K MARJAN B | 2011 | Lancet2011，378，9809： | 1 |
| 18 | Metastatic melanoma to the common bile duct causing obstructive jaundice:A case report显示文摘Metastatic melanoma to the common bile duct is very rare with only 18 cases reported so far. We report a 46 year old women who, 18 mo after excision of a skin melanoma, developped a painless progressive obstructive jaundice. At operation a melanoma within the distal third of the common bile duct was found. There were no other secondaries within the abdomen. The common bile duct, including the tumor, was resected and anastomosed with Roux-en-Y jejunal limb. The patient survived 31 mo without any sign of local recurrence and was submitted to three other operations for axillar and brain secondaries, from which she finally died. Radical resection of metastatic melanoma to the common bile duct may result in lifelong relief of obstructive jaundice. It is safe and relatively easy to perform. In other cases, a less aggressive approach, stenting or bypass procedures, should be adopted. | Radoje B Colovic Nikica M Grubor Miodrag D Jovanovic Marjan T Micev Natasa R Colovic | 2007 | World Journal of Gastroenterology2007，13，5： | 1 |
| 19 | Compact 2-D graphical representation of DNA 显示文摘 | Randie M Vraeko Marjan Zupan Jure | 2003 | Chem Plays Lett2003，373，5： | 1 |
| 20 | Enhancing the microbial conversion of glycerol to 1,3-propanediol using metabolic engineering 显示文摘 | VEERLE E T M MARJAN D M JOERI B | 2011 | Organic Process Research & Development2011，15，1： | 1 |
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