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22篇 您的检索式：作者名="MAIK J"

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	题名	作者	年代	出处	被引量
1	Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors.	Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler	2008	World Journal of Gastroenterology2008，14，24：	2
2	Aneurysmal subarachnoid hemorrhage in elderly patients: long-term outcome and prognostic factors in an interdisciplinary treatment approach显示文摘	Karsten Sch?ller Maike Massmann Gertraud Markl Mathias Kunz Gunther Fesl Hartmut Brückmann Thomas Pfefferkorn J?rg-Christian Tonn Christian Schichor	2013	Journal of Neurology2013，，4：	1
3	The influence of earthworms and organic additives on the biodegradation of oil contaminated soil显示文摘	Maike S Filser J	2007	Applied soil ecology2007，36，：	1
4	Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rats 显示文摘	GARRY M G MAIK S YU J	2000	Neuroport2000，11，：	1
5	Rosmarinic acid显示文摘	Maike Petersen Monique S J Simmonds	2003	Phytochemistry2003，62，3：	1
6	Archaeological textiles-a need for methods of analysis and reconstruction显示文摘	CYBULSKA M MAIK J	2007	Fibers & Textiles in Eastern Europe2007，，15：	1
7	Amortization Policy for Advertising and Research and Development Expenditures显示文摘	Hirschey Maik Weygandtjeery J	1985	Journal of accounting Research1985，3，：	1
8	Early arrival waveform tomography on near-surface refraction data显示文摘	Sheng J M Alan L Maike B		0，，4：	1
9	Analyzing sub - 100 - um samples with transmission terahertz time domain spectroscopy 显示文摘	MAIK S CHRISTIAN J MARTIN K		Optics Communications0，282，6：	1
10	Noise-adaptive spatio- temporal filter for real-time noise removal in low light level images显示文摘	Seong Won L Maik Vdihoon J	2005	Consumer Electronics IEEE Transactions on2005，51，2：	1
11	Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rats显示文摘	GARRY M G MAIK S YU J	2000	Neuroport2000，11，：	1
12	CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice显示文摘	Weber Christian Meiler Svenja D?ring Yvonne Koch Miriam Drechsler Maik Megens Remco T A Rowinska Zuzanna Bidzhekov Kiril Fecher Caroline Ribechini Eliana van Zandvoort Marc A M J Binder Christoph J Jelinek Ivett Hristov Mihail Boon Louis Ju	2011	Journal of Clinical Investigation2011，，7：	1
13	Normalized cuts and image segmentation 显示文摘	Shi J Maik J	2000	IEEE Transactions on Pattem Analysis and MachineIntelligence2000，22，8：	1
14	Review of A2B207 pyrochlore response to irradiation and pressure 显示文摘	Maik L Xiang Z F Ming Z J	2010	Nu- clear Instruments and Methods in Physics Research B2010，268，：	1
15	The silence of genes in transgenic plants显示文摘	Maike S Joseph N M Koeter J M	1997	Annals of Botany1997，79，：	1
16	Purification,cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei显示文摘	Kyung H K Verena J Maike P	2004	Plant Mol Biol2004，54，3：	1
17	Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rats显示文摘	GARRY M G MAIK S YU J	2000	Neuroport2000，11，：	1
18	Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rats显示文摘	GARRY MG MAIK S YU J	2000	Neuroport2000，11，：	1
19	Gene prediction in metagenomic fragments: A large scale machine learning approach 显示文摘	Katharina J Hoff Maike Tech Thomas Lingner	2008	BioMed Central2008，217，9：	1
20	A flow-cytometry based cytotoxicity assay using stained effector cells in combination with native target cells显示文摘	Maike H Luhm J Schlenke P	2002	Immunological Methods2002，267，：	1

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