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| 1 | Correlations between skin lesions induced by anti-tumor necrosis factor-α and selected cytokines in Crohn's disease patients显示文摘AIM:To investigate the correlation between the appearance of skin lesions and concentration of interleukin(IL)-17A,IL-23 and interferon-γ(IFN-γ)in Crohn’s disease(CD)patients during anti-tumor necrosis factor-α(TNF-α)therapy METHODS:A prospective study included 30 adult patients with CD of Caucasian origin(19 men and 11women;mean age±SD 32.0±8.6 years)during biological therapy with anti-TNF-αantibodies from January2012 to March 2013.Eighteen patients were treated with infliximab,seven with adalimumab and five withcertolizumab.Inclusion criteria were exacerbation of the underlying disease,Crohn’s Disease Activity Index over 300 and the ineffectiveness of previously used non-biological therapies.Patients with a history of psoriasis,atopic dermatitis and other autoimmune skin lesions were excluded from the study.The control group consisted of 12 healthy subjects.A diagnostic survey was carried out,blood tests and careful skin examination were performed,and the serum levels of IL-17,IL-23 and IFN-γwere measured using an enzyme-linked immunosorbent assays technique.Dermatoses that have developed in the course of biological therapy in patients who had no pre-existing skin lesions of similar character were qualified as skin lesions induced by antiTNF-αtherapy.RESULTS:Skin manifestations occurred in 18 of CD patients during the anti-TNF-αtherapy(60%),in the average time of 10.16±3.42 mo following the beginning of the 52-wk treatment cycle.Skin lesions observed in CD patients during biological therapy included psoriasiform lesions(44.4%),and eczema forms lesions(22.2%).In CD patients with drug induced skin lesions significantly higher levels of hemoglobin(13.3±1.5 g/dL vs 10.8±1.9 g/dL,P=0.018)and hematocrit(39.9%±4.5%vs 34.3%±5.4%,P=0.01),as well as a significantly lower level of platelets(268±62×103/μL vs 408±239×103/μL,P=0.046)was observed compared with CD patients without skin manifestations.The concentrations of IL-17A and IL-23in CD patients with skin lesions developed under antiTNF-αtherapy were significantly higher compared to those in patients without lesions(IL-17A:39.01±7.03pg/mL vs 25.71±4.90 pg/mL,P=0.00004;IL-23:408.78±94.13 pg/mL vs 312.15±76.24 pg/mL,P=0.00556).CONCLUSION:Skin lesions in CD patients during bio-logical therapy may result from significantly increased concentrations of IL-17A and IL-23,which are strongly associated with TNF-α/Th1 immune pathways. | Marcin Wodarczyk Aleksandra Sobolewska Bartosz Wójcik Karolina Loga Jakub Fichna Maria Wisniewska-Jarosińska | 2014 | World Journal of Gastroenterology2014，20，22： | 2 |
| 2 | Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70显示文摘AIM: To determine whether ischemic preconditioning (IP)affects the development of edematous cerulein-induced pancreatitis and to assess the role of cyclooxygenase-1 (COX-1), COX-2, and heat shock protein 70 (HSP 70) in this process.METHODS: In male Wistar rats, IP was performed by damping of celiac artery (twice for 5 min at 5-min intervals).Thirty minutes after IP or sham operation, acute pancreatitis was induced by cerulein. Activity of COX-1 or COX-2 was inhibited by resveratrol or rofecoxib, respectively (10 mg/kg).RESULTS: IP significantly reduced pancreatic damage in cerulein-induced pancreatitis as demonstrated by the improvement of pancreas histology, reduction in serum lipase and poly-C ribonuclease activity, and serum concentration of pro-inflammatory interleukin (IL)-1β.Also, IP attenuated the pancreatitis-evoked fall in pancreatic blood flow and pancreatic DNA synthesis.Serum level of anti-inflammatory IL-10 was not affected by IP. Cerulein-induced pancreatitis and IP increased the content of HSP 70 in the pancreas. Maximal increase in HSP 70 was observed when IP was combined with cerulein-induced pancreatitis. Inhibition of COXs, especially COX-2, reduced the protective effect of IP in edematous pancreatitis.CONCLUSION: Our results indicate that IP reduces pancreatic damage in cerulein-induced pancreatitis and this effect, at least in part, depends on the activity of COXs and pancreatic production of HSP 70. | Zygmunt Warzecha Artur Dembinski Piotr Ceranowicz Stanislaw J Konturek Marcin Dembinski Wieslaw W Pawlik Romana Tomaszewska Jerzy Stachura Beata Kusnierz-Cabala Jerzy W Naskalski Peter C Konturek | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 3 | Pilot plant results for advanced CO2 capture process using amine scrubbing at the Jaworzno power plant in Poland 显示文摘 | Marcin S Adam T Lucyna W | 2015 | Fuel2015，151，1： | 1 |
| 4 | Estimation and testing of the Hurst parameter using p-variation显示文摘 | MARCIN M JAKUB K JUSTYNA W | 2013 | Journal of Physics A:Mathematical and Theoretical2013，46，32： | 1 |
| 5 | Structure and properties of Ni-Mn-Ga magnetic shape memory alloys containing minor addition of terbium显示文摘 | RAFAL W MARCIN L ZHAO Zeng-qi JIANG Li-ping | 2007 | Journal of Magnetism and Magnetic Materials2007，316，： | 1 |
| 6 | Decreased plasma adiponectin concentration in patients with essential hypertension 显示文摘 | MARCIN A ANDRZEJ W TOHRU F | 2003 | Am J Hypertens2003，16，： | 1 |
| 7 | Synthesis and spectral properties of colloidal Nd3 - doped NaYF4 nanocrystals 显示文摘 | Artur B Dominika W Marcin N Wieslaw S | 2011 | Optical Materials2011，33，： | 1 |
| 8 | Neuro-wavelet classifiers for EEG signals based on rough set methods显示文摘 | Marcin S Piotr W | 2001 | IEEE Trans on Neurocomputing2001，36，1： | 1 |
| 9 | Towards robustness in neural network based fault diagnosis 显示文摘 | KRZYSZTOF P MARCIN W JOZEF K | 2008 | International Journal Applied Math Computation Science2008，18，4： | 1 |
| 10 | Neuro-wavelet classifiters for EEG signals based on rough set methods显示文摘 | Marcin S Piotr W | 2001 | Neurocomputing2001，36，1： | 1 |
| 11 | Influence of Cr additional to Raney Ni catalyst on hydrogenation of isophorone 显示文摘 | Marcin P Mariusz L Piotr W | 2008 | Catalysis Communications2008，10，2： | 1 |
| 12 | CXCR7 : a new SDF - 1 - bind- ing receptor in contrast to normal CD34 ( + ) progenitors is functional and is expressed at higher level in human malignant hematopoietic cells 显示文摘 | Maciej T Rui L Marcin W | 2010 | EurJHaematol2010，85，6： | 1 |
| 13 | Relationship between aortic pulse wave velocity, selected proinflammatory cytokines, and vascular calcification parameters in peritoneal dialysis patients显示文摘 | Marcin Krzanowski Katarzyna Janda Paulina Dumnicka Marzena Dubiel Ma?gorzata Stompór Beata Ku?nierz-Cabala Tomasz Grodzicki W?adys?aw Su?owicz | 2014 | Journal of Hypertension2014，，1： | 1 |
| 14 | Decreased plasma adiponectin concentration in patients with essential hypertension显示文摘 | Marcin A Andrzej W Tohru F | 2003 | Am J Hypertension2003，16，1： | 1 |
| 15 | Decreased plasma adiponectin concentration in patients with essential hypertension显示文摘 | Marcin A Andrzej W Tohru F | 2003 | Am J Hypertension2003，16，1： | 1 |
| 16 | Decreased plasma adiponeetin concentration in patients with essential hypertension 显示文摘 | Marcin A Andrzej W Tohru F | 2003 | Am J Hy- pertens2003，16，1： | 1 |
| 17 | Decreased plasma adiponectin concentration in patients with essential hypertension 显示文摘 | Marcin A Andrzej W Tohru F | 2003 | Am J Hypertension2003，16，1： | 1 |
| 18 | Decreased plasma adiponectin concentration in patients with essential hypertension显示文摘 | Marcin A Andrzej W Tohru F | 2003 | Am J Hypertension2003，16，1： | 1 |
| 19 | Histological and histochemical assessment of the effects of a single dose adriamycin on fetal rat kidney显示文摘 | AGNIESZKA P MARCIN W KRYSTYNA C | 2005 | Acta Histochemica2005，107，2： | 1 |
| 20 | The effects of cold acclimation on photosynthetic apparatus and the expression of COR14b in four genotypes of harley (Hordeum vulgare) contrasting in their tolerance to freezing and high-light treatment in cold eondi- tions显示文摘 | MARCIN R BARBARA W KATARZYNA H | 2008 | Annals of Botany2008，101，： | 1 |
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