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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Distribu- tion of Tol - like receptors 4 in term and preterm human placentas from normal and complicated pregnancy including chofiamnionitis 显示文摘 | Kaori K Masahiro N Itaru Y | 2004 | Human Pathol2004，35，： | 1 |
| 3 | The wide spectrum of clinicalmanifestations in Sjogren's syndrome-associated neuropathy 显示文摘 | Keiko M Masahiro I Haruki K | 2005 | Brain2005，128，11： | 1 |
| 4 | Adiponectin prevents atherosclerosis by increasing cholesterol effiux from macrophages 显示文摘 | KAZUMI T Y FUMIHIKO M MASAHIRO K | 2008 | Biochemical and Biophysical Research Communications2008，375，3： | 1 |
| 5 | Diagnostic use of serum deoxyribonuclease Ⅰ activity as a novel early-phase marker in acute myocardial infarction 显示文摘 | Yasuyuki K Masahiro Y Kenichiro A | 2004 | Circulation2004，109，5： | 1 |
| 6 | Effect of Morphology of Carbon Black Fillers on the Tribological Properties of Fibrillated PTFE显示文摘 | Yoshinori T Agung W Masahiro K | 2008 | Wear2008，264，34： | 1 |
| 7 | P-type Electrical Conduction in Transparent Thin Films of CuAlO2 显示文摘 | Hiroshi K Masahiro Y Hiroyuki H | 1997 | Nature1997，359，30： | 1 |
| 8 | 显示文摘 | Parhat A Takshi K Masahiro T | 2002 | Applied Surface Science2002，189，： | 1 |
| 9 | Effect of ultra- sonic irradiation on the behavior of primary nucleation of amino acids in supersaturated solutions 显示文摘 | Masahiro K Etsuko M Satomi E | 2009 | Journal of Crystal Growth2009，311，9： | 1 |
| 10 | Clinical results of single-level posterior lumbar interbody fusion using the brantigan I/F carbon cage filled with a mixture of local morselized bone and bioactive ceramic granules显示文摘 | Tomoyuki H Kciichi S Masahiro K | 2002 | Spine2002，27，3： | 1 |
| 11 | Novel effective poly(2,2′-bipyridine-5,5′-diyl)-CuCl2 catalyst for synthesis of dimethyl carbonate (DMC) by oxidative carbonylation of methanol显示文摘 | Yasushi S Masahiro K Takakazu Y | 1999 | Applied Catalysis A: General1999，，185： | 1 |
| 12 | Wear and mechanical properties of sintered copper-tin composites containing graphite or molybdenum disulfide显示文摘 | Hirotaka K Masahiro T Yoshiro I | 2003 | Wear2003，255，123456： | 1 |
| 13 | Chloroplast Unusual Positioning Is Essential for Proper Chloroplast Positioning 显示文摘 | KAZUSATO O MASAHIRO K TOMOHITO K | 2003 | The Plant Cell2003，9，15： | 1 |
| 14 | Effects of surface oxidesof the phosphatability of the high strengh (’old rolled steels 显示文摘 | Masahiro N Ikuro H Shinji K | 2006 | Testsu to Humane2006，92，6： | 1 |
| 15 | Effects of Ag and Cu addition on microstructural properties and oxidation resistance of Sn-Zn eutectic alloy显示文摘 | Lee J E Kimb K S Masahiro I | 2008 | Joumal of Alloys and Compounds2008，454，12： | 1 |
| 16 | A new type of support ''bipyridine containing aromatic polyamide'' to CuCl2 for synthesis of dimethyl carbonate (DMC) by oxidative carbonylation of methanol显示文摘 | Yasushi S Masahiro K Yoshie S | 2000 | Journal of Molecular catalysis A: Chemical2000，，151： | 1 |
| 17 | Treatment of thoracolumbar fractures with vertebroplasty in combination with posterior instrumentation 显示文摘 | Masahiro K Yutaka I Daisuke S | 2005 | Neurosurg Q2005，15，9： | 1 |
| 18 | A growth signal with an artificially induced erythropoietin receptor-gp130 cytoplasmic domain heterodimer 显示文摘 | Masahiro K Hiroshi U Kouhei T | 2001 | Journal of Biochemistry2001，130，： | 1 |
| 19 | Potent free radical scavenger, edaravone, suppresses oxi- dative stress-induced endothelial damage and early atherosclerosis 显示文摘 | Hang X Masahiro K Kumiko N | 2007 | Atherosclerosis2007，191，2： | 1 |
| 20 | Study of oxygen vacancies in SrTiO3 by positron annihilation 显示文摘 | Arira U Kazuo S Masahiro K | 2002 | J Appl Phys2002，92，： | 1 |
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