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| 1 | Intestinal bile acid physiology and pathophysiology显示文摘Bile acids (BAs) have a long established role in fat digestion in the intestine by acting as tensioactives, due to their amphipatic characteristics. BAs are reabsorbed very efficiently by the intestinal epithelium and recycled back to the liver via transport mechanisms that have been largely elucidated. The transport and synthesis of BAs are tightly regulated in part by specific plasma membrane receptors and nuclear receptors. In addition to their primary effect, BAs have been claimed to play a role in gastrointestinal cancer, intestinal inflammation and intestinal ionic transport. BAs are not equivalent in any of these biological activities, and structural requirements have been generally identified. In particular, some BAs may be useful for cancer chemoprevention and perhaps in inflammatory bowel disease, although further research is necessary in this field. This review covers the most recent developments in these aspects of BA intestinal biology. | Olga Martínez-Augustin Fermín Sánchez de Medina | 2008 | World Journal of Gastroenterology2008，14，37： | 7 |
| 2 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 3 | Effects of asymmetric dimethylarginine on renal arteries in portal hypertension and cirrhosis显示文摘AIM To evaluate the effects of asymmetric dimethylarginine(ADMA) in renal arteries from portal hypertensive and cirrhotic rats.METHODS Rat renal arteries from Sham(n = 15), pre-hepatic portal hypertension(PPVL; n = 15) and bile duct ligation and excision-induced cirrhosis(BDL; n = 15) were precontracted with norepinephrine, and additional contractions were induced with ADMA(10-6-10-3 mol/L), an endogenous inhibitor of nitric oxide(NO) synthase. Concentration-response curves to acetylcholine(1 × 10-9^(-3) × 10^(-6) mol/L) were determined in precontractedrenal artery segments with norepinephrine in the absence and in the presence of ADMA. Kidneys were collected to determine the protein expression and activity of dimethylarginine dimethylaminohydrolase(DDAH), an enzyme that catabolizes ADMA. RESULTS In renal arteries precontracted with norepinephrine, ADMA caused endothelium-dependent contractions. The pD 2 values to ADMA were similar in the Sham and PPVL groups(4.20 ± 0.08 and 4.11 ± 0.09, P > 0.05, respectively), but were lower than those of the BDL group(4.79 ± 0.16, P < 0.05). Acetylcholine-induced endothelium-dependent relaxation that did not differ, in terms of p D2 and maximal relaxation, among the 3 groups studied. Treatment with ADMA(3 × 10^(-4) mol/L) inhibited acetylcholine-induced relaxation in the 3 groups, but the inhibition was higher(P < 0.05) in the BDL group compared with that for the Sham and PPVL groups. The m RNA and protein expression of DDAH-1 were similar in kidneys from the three groups. Conversely, DDAH-2 expression was increased(P < 0.05) in PPVL and further enhanced(P < 0.05) in the BDL group. However, renal DDAH activity was significantly decreased in the BDL group. CONCLUSION Cirrhosis increased the inhibitory effect of ADMA on basal- and induced-release of NO in renal arteries, and decreased DDAH activity in the kidney. | Gloria Segarra Belén Cortina María Dolores Mauricio Susana Novella Paloma Lluch Javier Navarrete-Navarro Inmaculada Noguera Pascual Medina | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 4 | Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience显示文摘AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG-PET/CT) during radiation therapy(RT) for human papillomavirus negative(HPV-) head and neck squamous cell carcinoma(HNSCC).METHODS In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations(DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during-(2-3 wk), and post-treatment(Tx), and 18F-FDG PET/CT pre- and post-Tx(n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC) and the mean of standardized uptake value(SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTS There was a strong negative correlation between the mean of pretreatment ADC(ρ =-0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage(%) change in delta(?) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSION These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience. | David Aramburu Núnez Antonio Lopez Medina Moisés Mera Iglesias Francisco Salvador Gomez Abhay Dave Vaios Hatzoglou Ramesh Paudyal Alfonso Calzado Joseph O Deasy Amita Shukla-Dave Victor M Munoz | 2017 | World Journal of Radiology2017，9，1： | 2 |
| 5 | Public-health impact of outdoor and traffic-related air pollution: a European assessment 显示文摘 | Kunzli N Kaiser R Medina S | 2000 | Lancet2000，356，79： | 1 |
| 6 | Thermal biology and locomotor performance in Phymaturus calcogaster:are Patagonian lizards vulnerable to climate change?显示文摘Behavioral and physiological traits of ectotherms are especially sensitive to fluctuations of environmental temperature.In particular,niche-specialist lizards are dependent on their physiological plasticity to adjust to changing environmental conditions.Lizards of the genus Phymaturus are viviparous,mainly herbivorous,and inhabit only rock promontories in the steppe environments of Patagonia and the Andes.Herein,we examine the vulnerability of the southernmost Phymaturus species to global warming:the endemic Phymaturus calcogaster,which lives in a mesic environment in eastern Patagonia.We studied body temperatures in the field(T_(b)),preferred body temperatures in a thermogradient(T_(pref)),the operative(T_(e))and environmental temperatures,and the dependence of running performance on body temperature.P.calcogaster had a mean T_(b)(27.04℃)and a mean Te(31.15℃)both lower than their preferred temperature(T_(pref)=36.61℃)and the optimal temperature for running performance(T_(o)=37.13℃).Lizard activity seems to be restraint during the early afternoon due high environmental temperatures.However,both,the high safety margin and warming tolerance suggest that the expected increase in environmental temperatures due to global warming(IPCC report in 2018)would not threaten,but indeed enhance locomotor performance in this population. | Rosa L.OBREGÓN Jose A.SCOLARO Nora R.IBARGÜENGOYTÍA Marlin MEDINA | 2021 | Integrative Zoology2021，16，1： | 1 |
| 7 | Mapping the operation of the DMT continuous flow CCN counter 显示文摘 | Lance S Medina J Smith J N | 2006 | Aerosol Science and Technology2006，40，17： | 1 |
| 8 | Stabilization of lateritic soilswith phosphoric acid显示文摘 | Medina J Guide H N | 1995 | Geotechnical and GeologicalEngineering1995，13，4： | 1 |
| 9 | Public health impact of outdoor andtraffic-related air pollution:a European assessment显示文摘 | Künzli N Kaiser R Medina S | 2000 | Lancet2000，356，： | 1 |
| 10 | Stabilization of lateritic soils with phosphoricacid 显示文摘 | Medina J Guida H N | 1995 | Geotechnical and Geological Engineering1995，13，4： | 1 |
| 11 | On the fast approximation of Gteen's functions in MPIE formutations for planar layered media显示文摘 | SHULEY N V BOlX R R MEDINA F HORNO M | 2002 | IEEE Transactions on Microwave Theory and Techniques2002，50，9： | 1 |
| 12 | Neurologic outcome of minimal head injury patients managed with or without a routine repeat head computed tomography显示文摘 | Nayak N V Medina B Patel K | | 0，，2： | 1 |
| 13 | Fine organization of Bombyx mori fibroin heavy chain gene显示文摘 | ZHOU C Z CONFALONIERI F MEDINA N | 2000 | Nucleic Acides Research2000，28，： | 1 |
| 14 | Mieronutrients and innate immunity显示文摘 | Erickson K L Medina E A Hubbard N E | 2000 | J Infect Dis2000，182，1： | 1 |
| 15 | Sinonasal nureoendocrine carcinoma in association with SLADH显示文摘 | VASAN N R MEDINA J E CANFIELD V A | 2004 | Head Neck2004，26，： | 1 |
| 16 | Differential Role of Hippocampal cAMP-Dependent Protein Kinase in Short- and Long-Term Memory显示文摘 | Monica R. M. Vianna Luciana A. Izquierdo Daniela M. Barros Patricia Ardenghi Patricia Pereira Cleverson Rodrigues Beatriz Moletta Jorge H. Medina Iván Izquierdo | 2000 | Neurochemical Research2000，，5： | 1 |
| 17 | Improved thin-layerchromatographic detection of diethylstilbestrol and zeranol inplasma and tissues isolated with alumina and ion-exchangemembrane columns in tandem 显示文摘 | Medina M B NAGDY N | 1993 | Journal of ChromatographyB: Biomedical Sciences and Applications1993，614，2： | 1 |
| 18 | Instructional design and assessment using team-based learning in an endocrine module taught across two eampuses显示文摘 | Letassy N A Fugate S E Medina M S l | 2008 | Am J Pharmae Edu2008，72，5： | 1 |
| 19 | Ester Synthesis by Lactic Acid Bacteria Isolated from Goat's and Ewe's Milk and Cheeses 显示文摘 | ABEIJ N MUKDSI M C MEDINA R B ALVAREZ M D F | 2009 | Food Chemistry2009，117，2： | 1 |
| 20 | Intrahepatic cholestasis of pregnancy , an unpredictable fetal risk : report of a case and review of the literature显示文摘 | Medina Lomeli JM Medina Castro N | 2000 | Gineool Obstet Mex2000，，68： | 1 |
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