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| 1 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 2 | Factors associated with low cure rate of tuberculosis in remote poor areas of Shanxi Province,China:a case control study显示文摘 | AI X MEN K GUO L | | 0，，： | 1 |
| 3 | Preparation of core cross - linked PCL - PEG - PCL micelles for doxorubicin delivery in vitro 显示文摘 | ZHANG J MEN K GU Y | 2011 | J Nanosci Nanotechnol2011，11，6： | 1 |
| 4 | Accumulation and local proliferation of antigen-specific CD4 + T ceils in antigen-bearing tissue显示文摘 | Doebis C Menning A Neumann K | 2010 | Immunol Cell Biol2010，89，4： | 1 |
| 5 | Improved survival of vitrified porcine embryos after partial delipation through chemically stimulated li-polysis and inhibition of apoptosis显示文摘 | Men H Agca Y Riley L K | 2006 | Theriogenology2006，66，： | 1 |
| 6 | A role for the human NLR family member NLRC5 in antiviral responses 显示文摘 | Sven K Andreas T Menning et a/ | 2010 | J Biol Chem2010，285，26： | 1 |
| 7 | Association between genomic heterogeneity of hepatitis B virus and intrauterine infection显示文摘 | Cheng H Su H Wang Sv Shao Z Men K Li M | 2009 | Virology2009，387，： | 1 |
| 8 | Distinctive role of CCR7 in migration and functional activity of naive- and effector/ memory-like Treg subsets 显示文摘 | Menning A Hopken U E Siegmund K | 2007 | Eur J Immunol2007，37，6： | 1 |
| 9 | Who is telling what from where? A functional magnetic resonance imaging study显示文摘 | Mathiak K Menning H Hertrich I | 2007 | Neuroreport2007，18，5： | 1 |
| 10 | Dispersion and tensile behavior of polypropylene/montmorillonite nanocomposites produced via melt intercalation显示文摘 | Zhang Q Wang K Men Y | | 0，，3： | 1 |
| 11 | Ab Initio Calculations of Elastic Properties of Compressed Pt显示文摘 | Menéndez-Proupin E Singh A K | 2007 | Phys Rev B2007，76，05： | 1 |
| 12 | Triaxial failure criterion for concrete and its generalization显示文摘 | Menétrey Ph William K J | 1995 | ACI Structural Journal1995，92，： | 1 |
| 13 | A role for the human nucleotide-binding domain,leucine-rich repeat-containing family member NLRC5 in antiviral responses显示文摘 | Neerincx A Lautz K Menning M | | 0，，34： | 1 |
| 14 | A simple way to make tough ceramics 显示文摘 | CLEGG W J KENDALL K ALFORD N MeN | 1990 | Nature1990，347，： | 1 |
| 15 | Treating acute cystitis with biodegrad- able micelle- encapsulated QC 显示文摘 | Wang BL Gao X Men K | 2012 | Int J Nanomedicine2012，7，： | 1 |
| 16 | Superhydrophilic surfaces for antifogging and antifouling mi- crofluidic devices显示文摘 | Pragneshkumar Patel Chang K Choi Dennis Desheng Men | 2010 | J Assoc Lab Autom2010，15，2： | 1 |
| 17 | Soft magnetic FeSiBPCu hetero-amorphous alloys with high Fe content 显示文摘 | Makino A Men H Yubuta K | 2009 | J Appl Phys2009，105，01： | 1 |
| 18 | Response of vacuolarprocessing enzyme in Malus hupehensis and Mh VPEc-overex-pressing Arabidopsis to high temperature stress显示文摘 | SU Q RAN K MEN X J ZHANG W W | 2015 | Acta Physiolo-giae Plantarum2015，37，4： | 1 |
| 19 | Electrical properties of AIN thin films prepared by ion beam enhanced deposition 显示文摘 | An Z H Men C L Xu Z K | 2005 | Surface&Coatings Technology2005，196，： | 1 |
| 20 | ENOS-G894T polymorphism isa risk factor for essential hypertension in China显示文摘 | Men C Tang K Lin G Li J Zhan Y | 2011 | IndianJ Biochem Biophys2011 Jun2011，48，3： | 1 |
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