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| 1 | Influence of water content and shear rate on the mechanical behavior of soil-rock mixtures显示文摘Soil-rock mixtures(S-RMs) are widely distributed in the nature. The mesoscopic deformation and failure mechanisms as well as the macro-mechanical behaviors of the S-RMs depend largely upon the rate of deformation, water content and particle sizes. In this research, a series of large-scale direct shear tests with different water contents and different grain-size distributions were conducted to study the influence of the aforementioned factors on the mechanical properties of the S-RMs. Due to the effect of the rock blocks' breakage in the S-RMs, the relationship between the shear strength and the vertical stress of S-RM follows a power law instead of a linear one. It is found that there exists a threshold value for the vertical stress during the shearing process,below which the soil strength is mainly determined by the inter-locking of particles and the re-arrangement of meso-structure,and otherwise large-sized rock blocks are gradually broken into smaller fragments, resulting in a decrease in the soil strength.The shear rate can also significantly influence the degree of particle breakage and the meso-structural rearrangement of the SRMs, namely, under low shear rate, the particles of the samples are fully broken resulting in enhanced macro-strength. As a result, the lower the shear rate, the higher the macroscopic strength. So under unsaturated conditions, the water content will affect the strength of the S-RMs by reducing the strength of rock blocks. As the water content increases, the soil strength decreases gradually, and assumes a moderate value when the water content reaches 8%. At the same water content, the soil strength increases with the sizes of large rock blocks. For the occlusion, breakage and structure re-arrangement of the oversized rock blocks inside S-RM, which have a huge influence on the mechanical characteristics of the samples. | WEI HouZhen XU WenJie WEI ChangFu MENG QingShan | 2018 | Science China(Technological Sciences)2018，61，8： | 5 |
| 2 | Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism显示文摘 | Dan Meng Xin Wang Qingshan Chang Andrew Hitron Zhuo Zhang Mei Xu Gang Chen Jia Luo Binghua Jiang Jing Fang Xianglin Shi | 2010 | Toxicology and Applied Pharmacology2010，，3： | 1 |
| 3 | Arsenic promotes angiogenesis in vitro via a heine oxygenase-l-dependent mechanism 显示文摘 | MENG Dan WANG Xin CHANG Qingshan | 2010 | Toxicol Appl Pharmacol2010，244，3： | 1 |
| 4 | Effect of coral sand on the mechanical properties and hydration mechanism of magnesium potassium phosphate cement mortar显示文摘Damaged structures on coral islands have been spalling and cracking due to the dual corrosion of tides and waves.To ensure easy access to aggregate materials,magnesium potassium phosphate cement(MKPC)and coral sand(CS)are mixed to repair damaged structures on coral islands.However,CS is significantly different from land-sourced sand in mineral composition,particle morphology,and strength.This has a substantial impact on the hydration characteristics and macroscopic properties of MKPC mortar.Therefore,in this study we investigated the compressive strength,interfacial mechanical properties,and corrosion resistance of MKPC CS mortar.Changes in the morphology,microstructure,and relative contents of hydration products were revealed by scanning electron microscope-energy dispersive spectrometer(SEM-EDS)and X-ray diffraction(XRD).The results indicated that the compressive strength increased linearly with the interfacial micro-hardness,and then stabilized after long-term immersion in pure water and Na2SO4 solution,showing excellent corrosion resistance.Compared with MKPC river sand(RS)mortar,the hydration products of CS mortar were an intermediate product 6KPO2·8H2O with a relative content of 3.9%at 1 h and 4.1%at 12 h.The hydration product MgKPO_(4)·6H_(2)O increased rapidly after 7-d curing,with an increased growth rate of 1100%.Our results showed that CS promoted the nucleation and formation of hydration products of MKPC,resulting in better crystallinity,tighter overlapping,and a denser interfacial transition zone.The results of this study provide technical support for applying MKPC mortar as a rapid repair material for damaged structures on coral islands. | Hao LIU Huamei YANG Houzhen WEI Jining YU Qingshan MENG Rongtao YAN | 2024 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2024，25，2： | 0 |
| 5 | Differing migration patterns and year-round habitat-use of allopatric nesting Eastern Tundra Bean Geese(Anser fabalis serrirostris)in East Asia显示文摘Sympatric Chinese-wintering Eastern Tundra Bean Geese(Anser fabalis serrirostris,ETBG)breed in two widely separated Arctic areas(Central Russian Arctic and Anadyr region);South Korean-wintering birds(Chaun-South Korea)breed in a third discrete area between these two.Such winter/summer segregation likely structures the population,potentially resulting in distinct migration patterns and habitat-use throughout the annual cycle.We tracked individuals using GPS-GSM transmitters from all three of these geographically discrete ETBG subpopulations to see whether this was the case,testing for differences in migration patterns,seasonal and diurnal habitat-use using remotely sensed land-cover mapping.Mean migration distance of Central Arctic-China and Chaun-South Korea individuals did not differ significantly,but Anadyr-China birds travelled 15–24%further(mean:1140 km,P<0.001).Despite this,mean spring migration durations were longest among Central ArcticChina ETBG,significantly longer than Anadyr-China geese,due to significantly longer stopovers,which were significantly longer than Chaun-South Korea birds.Autumn migration duration of Central Arctic-China and Chaun-South Korea individuals was significantly shorter than in spring,with fewer,shorter stopovers.Lack of significant differences in migration and stopover duration or numbers of stopovers between spring and autumn among Anadyr-China ETBG confirms this is a plastic trait,differing between subpopulations responding to prevailing conditions.Migration patterns and habitat-use differed significantly between all three ETBG subpopulations,although all tended to use wetlands more at night and croplands more in daytime in winter,suggesting specific adaptations and responses to differing conditions encountered along their different migration routes.Although untestable,we speculate that differences in habitat-use may affect fitness levels and genetic exchange between subpopulations,but based on our observations,conclude clear differences in migration and foraging ecology between these elements of the same subspecies,even in winter sympatry. | Fanjuan Meng Jing Zhang Chang Li Qingshan Zhao Diana Solovyeva Hansoo Lee Liding Chen Lei Cao Anthony David Fox | 2022 | Avian Research2022，13，4： | 0 |
| 6 | Brain-targeted polymersome codelivery of siRNA and temozolomide for effective glioblastoma chemo-RNAi synergistic therapy显示文摘Temozolomide (TMZ) is a clinically approved drug for glioblastoma (GBM) therapy. However, as a result of methylguanine-DNA-methyltransferase (MGMT), which is able to repair damaged DNA-damage repairing, TMZ usually yields unsatisfactory therapeutic effects. Small interfering RNA (siRNA) is a potential alteration tool for sensitivity of TMZ by targeting DNA repair enzymes. However, a suitable TMZ and siRNA codelivery system that can effectively and actively co-deliver siRNA/TMZ into the brain tumor is lacking. In this study, we constructed an angiopep-2 decorated polymersomal delivery system to co-deliver TMZ/siRNA for synergistic GBM therapy. This targeted polymersomal nanomedicine not only enhanced the circulation time of siRNA/TMZ in blood but also improved their blood-brain barrier (BBB) crossing and GBM targeting ability. Moreover, when we co-administered siRNAs specific to retinoblastoma binding protein 4 (RBBP4) together with TMZ in GBM cells, these RBBP4- specific siRNA (siRBBP4) modulated the sensitivity of TMZ by regulating MGMT, and thus showed a powerful synergistic anti-tumor effect. We demonstrated that angiopep-2 decorated polymersomal siRBBP4/TMZ co-loaded nanomedicines are capable of inhibiting tumor growth and significantly improved life expectancy of orthotropic GBM bearing mice. Overall, our study suggests that such a polymersomal TMZ/siRNA codelivery system provides a robust and potent nanoplatform for targeted GBM chemo-RNAi therapy. | Meng Zheng Chengnan Yan Qingshan Yang Feiyan Zhu Qiuli Du Xue Xia Marco Morsch Albert Lee Jinglong Yin Yan Zou Bingyang Shi | 2022 | ChemPhysMater2022，1，3： | 0 |
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