|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo显示文摘Estrogen is implicated as playing an important role in aging and tumorigenesis of estrogen responsive tissues;however the mechanisms underlying the mitogenic actions of estrogen are not fully understood.Here we report that estrogen deficiency in mice caused by targeted disruption of the aromatase gene results in a signi-ficant inhibition of telomerase maintenance of telomeres in mouse ovaries in a tissue-specific manner.The inhibition entails a significant shortening of telomeres and compromised proliferation in the follicular granulosa cell compartment of ovary.Gene expression analysis showed decreased levels of proto-oncogene c-Myc and the telomerase catalytic subunit,telomerase reverse transcriptase(TERT),in response to estrogen deficiency.Estrogen replacement therapy led to increases in TERT gene expression,telomerase activity,telomere length and ovarian tissue growth,thereby reinstating ovary development to normal in four weeks.Our data demonstrate for the first time that telomere maintenance is the primary mechanism mediating the mitogenic effect of estrogen on ovarian granulosa cell proliferation by upregulating the genes of c-Myc and TERT in vivo.Estrogen deficiency or over-activity may cause ovarian tissue aging or tumorigenesis,respectively,through estrogen regulation of telomere remodeling. | Sharyn Bayne He Li Margaret E.E.Jones Alex R.Pinto Michelle van Sinderen Ann Drummond Evan R.Simpson Jun-Ping Liu | 2011 | Protein & Cell2011，2，4： | 8 |
| 2 | Hepatitis B surface antigen quantification: Why and how to use it in 2011 – A core group report显示文摘 | Henry Lik-Yuen Chan Alex Thompson Michelle Martinot-Peignoux Teerha Piratvisuth Markus Cornberg Maurizia Rossana Brunetto Hans L. Tillmann Jia-Horng Kao Ji-Dong Jia Heiner Wedemeyer Stephen Locarnini Harry L.A. Janssen Patrick Marcellin | 2011 | Journal of Hepatology2011，，5： | 5 |
| 3 | A rare case of Staphylococcus lugdunensis septicemia associated with myocarditis and atrioventricular block显示文摘Myocarditis is a relatively rare,possibly life-threatening disease characterized by the inflammation of the myocardium.111 The disease pathogenesis is primarily initiated by acute injury and necrosis of cardiomyocytes,leading to an inflammatory response mediated by the immune system that can potentially cause further aggravation of myocardial damage and organ dysfunction.Prognosis in patients with myocarditis depends on the clinical presentation,which ranges from an asymptomatic disease course to the concomitant development of cardiac arrhythmias,heart failure,cardiogenic shock and even the occurrence of death in extreme cases[1]. | Alex Tsz Lai Nganh Sharen Lee Tong LIU Mark Tam Ka Hou Christien Li Michelle Vangi Wong Michael Huen Sum Lam Gary Tse Ishan Lakhani | 2019 | Journal of Geriatric Cardiology2019，16，1： | 2 |
| 4 | Future technology-enabled care for diabetes and hyperglycemia in the hospital setting显示文摘Patients with diabetes are increasingly common in hospital settings where optimal glycemic control remains challenging.Inpatient technology-enabled support systems are being designed,adapted and evaluated to meet this challenge.Insulin pump use,increasingly common in outpatients,has been shown to be safe among select inpatients.Dedicated pump protocols and provider training are needed to optimize pump use in the hospital.Continuous glucose monitoring(CGM)has been shown to be comparable to usual care for blood glucose surveillance in intensive care unit(ICU)settings but data on cost effectiveness is lacking.CGM use in non-ICU settings remains investigational and patient use of home CGM in inpatient settings is not recommended due to safety concerns.Compared to unstructured insulin prescription,a continuum of effective electronic medical record-based support for insulin prescription exists from passive order sets to clinical decision support to fully automated electronic Glycemic Management Systems.Relative efficacy and cost among these systems remains unanswered.An array of novel platforms are being evaluated to engage patients in technology-enabled diabetes education in the hospital.These hold tremendous promise in affording universal access to hospitalized patients with diabetes to effective self-management education and its attendant short/long term clinical benefits. | Alex Renato Montero Jeffrey S Dubin Paul Sack Michelle F Magee | 2019 | World Journal of Diabetes2019，10，9： | 2 |
| 5 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 6 | Cooling for acute ischemic brain damage (cool aid):an open pilot study of induced hypothermia in acute ischemic stroke显示文摘 | Derk WK Michel ADG Alex AC | 2001 | Stroke2001，32，8： | 1 |
| 7 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 8 | Hepatitis B surface antigen quantification: Why and how to use it in 2011 – A core group report显示文摘 | Henry Lik-Yuen Chan Alex Thompson Michelle Martinot-Peignoux Teerha Piratvisuth Markus Cornberg Maurizia Rossana Brunetto Hans L. Tillmann Jia-Horng Kao Ji-Dong Jia Heiner Wedemeyer Stephen Locarnini Harry L.A. Janssen Patrick Marcellin | 2011 | Journal of Hepatology2011，，5： | 1 |
| 9 | Treatment of polychlorinated biphenyls in two surface soils using catalyzed H 2 O 2 propagations显示文摘 | Mushtaque Ahmad Michelle A. Simon Alex Sherrin Mary Ellen Tuccillo Jeffrey L. Ullman Amy L. Teel Richard J. Watts | 2011 | Chemosphere2011，，7： | 1 |
| 10 | Evaluation of Grid Pattern Photocoagulation for Macular Edema in Central Vein Occlusion显示文摘 | John G. Clarkson Elaine Chuang Donald Gass Maria Pedroso Tony Cubillas Erlinda S. Duria Ditte J. Hess Isabel Rams Marguerite Ball Alex Gutierrez Nayla Muniz June Thompson Michele Pall Charles J. Pappas | 1995 | Ophthalmology1995，，10： | 1 |
| 11 | Behavioral supply management: A taxonomy of judgment and decision- making biases显示文摘 | CRAIG R Carter KAUFMANN Lutz MICHEL Alex | 2007 | International Journal of Physical Distribution & Logistics Management2007，37，8： | 1 |
| 12 | A Phase I/II Study of Erlotinib in Combination with the Anti-Insulin-Like Growth Factor-1 Receptor Monoclonal Antibody IMC-A12 (Cixutumumab) in Patients with Advanced Non-small Cell Lung Cancer显示文摘 | Andrew Weickhardt Robert Doebele Ana Oton Janice Lettieri DeLee Maxson Michele Reynolds Amy Brown Mary K. Jackson Grace Dy Araba Adjei Gerald Fetterly Xian Lu Wilbur Franklin Marileila Varella-Garcia Fred R. Hirsch Murry W. Wynes Hagop Youssoufian Alex Ad | 2012 | Journal of Thoracic Oncology2012，，2： | 1 |
| 13 | Evaluation of Outcomes in Patients With Carcinoma of the Cervix Treated With Concurrent Radiation and Cisplatin Versus Cisplatin/5-FU Compared With Radiation Alone显示文摘 | Eric D. Donnelly Tamer Refaat Michelle Gentile Alex Herskovic John Boyle Irene Helenowski Alfred Rademaker John Lurain Julian Schink Diljeet Singh Jonathan B. Strauss William Small | 2015 | American Journal of Clinical Oncology2015，，： | 1 |
| 14 | Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alla L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 15 | Hepatitis B surface antigen quantification:Why and how to use it in 2011 - A core group report显示文摘 | Henry L Y C Alex T Michelle M P | 2011 | J Hepato12011，55，5： | 1 |
| 16 | Distribution of Clostridium perfringens epsilon toxin in the brains of acutely intoxicated mice and its effect upon glial cells显示文摘 | Alex Soler-Jover Jonatan Dorca Michel R. Popoff Maryse Gibert Josep Saura Josep Maria Tusell Joan Serratosa Juan Blasi Mireia Martín-Satué | 2007 | Toxicon2007，，4： | 1 |
| 17 | Local Brain Temperature Reduction Through Intranasal Cooling With the RhinoChill Device: Preliminary Safety Data in Brain-Injured Patients显示文摘 | Alex Abou-Chebl Gene Sung Denise Barbut Michel Torbey | 2011 | Stroke2011，，8： | 1 |
| 18 | Dephosphorylation reactions of mono-, di-, and triesters of 2, 4-dinitrophenyl phosphate with deferoxamine and benzohydroxamic acid显示文摘 | Michelle M Elisa S O Alex M M | 2012 | The Journal of Organic Chemistry2012，23，77： | 1 |
| 19 | Quantifying fungal viability in air and water samples using quantitative PCR after treatment with propidium monoazide (PMA)显示文摘 | Stephen Vesper Craig McKinstry Chris Hartmann Michelle Neace Stephanie Yoder Alex Vesper | 2007 | Journal of Microbiological Methods2007，，2： | 1 |
| 20 | 观片:2019年度野生动物摄影师大赛获奖照片精选显示文摘韦德尔氏海豹摄影师Ralf Schneider黑白组推荐作品这只韦德尔氏海豹闭着眼睛,用脚蹼紧紧地抱着自己的身体,似乎陷入了沉睡。它躺在南乔治亚岛拉森港附近的冰上,对于其掠食者——虎鲸和豹海豹来说,这里相对安全,它可以稍微放松一下。 | 筑后川(翻译) Ralf Schneider(摄影) | 2020 | 摄影之友(影像视觉)2020，，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员