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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | The friction and wear of Ni-P-PTFE composite deposite and water lubrication 显示文摘 | Ming Der Ger Hou K H WANG L M | 2002 | Materials Chemistry and Physics2002，77，3： | 1 |
| 3 | The mutational spectrum of the sonic hedgehog gene in holorosencephaly: SHH mutations cause a significant proportion of autosomal dominant holorosencephaly显示文摘 | Nanni L Ming JE Bocian M | 1999 | Hum Mol Genet1999，8，13： | 1 |
| 4 | Molecular evolution and functional specialization of chalcone synthase superfamily from Phalaenopsis orchid显示文摘 | Han Y Y Ming F Wang W Wang J W Ye M M Sheng D L | 2006 | Genetica2006，128，123： | 1 |
| 5 | Structure and digestibility of endosperm water-soluble a-glucans from different sugary maize mutants 显示文摘 | MING M RONG L BO J | 2014 | Food Chemistry2014，143，143： | 1 |
| 6 | Studies on the effect of trading volume and return volatility on call warrant and underlying stocks in Taiwan显示文摘 | Chiu C L Ming C L Cho M L | 2005 | Quarterly Journal of Business&Economics2005，44，： | 1 |
| 7 | Polymerization of lactides and lactones, synthesis of poly and poly{ ( lactic acid) - co- } 显示文摘 | Deng X M Jin R Y Ming L Y | 2000 | Macromolecular Chemistry and Physics2000，201，： | 1 |
| 8 | 显示文摘 | Jianxin M Ming F Ngai Ting L | 1996 | J Catal1996，158，： | 1 |
| 9 | PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells显示文摘 | Sun Q Ming L Thomas S M | 2009 | Oncogene2009，28，24： | 1 |
| 10 | Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1/JNK and PI3K/Akt pathway显示文摘 | LIU C M ZHENG G H MING Q L | 2013 | Free Radic Res2013，47，3： | 1 |
| 11 | 查看详情显示文摘 | Zhang R Su J Q Wang J J Liu L Q Li E Jing F Zhang X M Xu L X Ming H | | 0，，： | 1 |
| 12 | Highly efficient predictive zonal algorithms for fast block-matching motion estimation 显示文摘 | Au Oscar C Liou Ming L | 2002 | IEEE Trans CSVT2002，12，10： | 1 |
| 13 | Fractionation of copper and cadmium and their binding with soil organic matter in a contaminated soil amended with organic materials显示文摘 | Ibrahim M Bocar A Ming L | 2010 | Journal of Soils and Sediments2010，10，： | 1 |
| 14 | Gibberella moniliformis AH13 with antitumor activity, an endophytic fungus strain producing triolein isolated from adlay (Coix lacryma-jobi: Poaceae ) 显示文摘 | JIA M MING Q L ZHANG Q Y | 2014 | Current Microbiology2014，69，： | 1 |
| 15 | Effect of the Lycium barbarum polysaccharides administration on blood lipid metabolism and oxidative stress of mice fed high-fat diet in vivo 显示文摘 | Ming M Guanhua L Zhanhai Y | 2009 | Food Chemistry2009，113，4： | 1 |
| 16 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 17 | Optimizing imatinib mesylate treatment in gastrointestinal stromal tumors显示文摘 | Jiang Y Ming L Montero AJ Kimchi E Nikfarjam M Staveley-O'Carroll KF | 2008 | Gastrointest Cancer Res2008，2，5： | 1 |
| 18 | Investigation of the microenvironment in nonionic reverse micelles using methyl orange and methylene blue as absorption probe 显示文摘 | QI L M Ma Ji - Ming | 1998 | J Colloid Interface Science1998，197，： | 1 |
| 19 | PTEN positively regulates UVB- induced DNA damage repair显示文摘 | Ming M Feng L Shea CR | 2011 | Cancer research2011，71，： | 1 |
| 20 | Functions and action mechanisms of fiavonoids genistein and icariin in regulating bone remodeling 显示文摘 | Ming L G Chen K M Xian C J | 2013 | Journal of cellular physiology2013，228，3： | 1 |
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