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| 1 | Plasma and platelet serotonin levels in patients with liver cirrhosis显示文摘AIM: To analyze the relationship between plasma and platelet serotonin levels and the degree of liver insufficiency. METHODS: The prospective study included 30 patients with liver cirrhosis and 30 healthy controls. The degree of liver failure was assessed according to the Child-Pugh classification. Platelet and platelet poor plasma serotonin levels were determined. RESULTS: The mean plasma serotonin level was higher in liver cirrhosis patients than in healthy subjects (215.0 ± 26.1 vs 63.1 ± 18.1 nmol/L; P < 0.0001). The mean platelet serotonin content was not significantly different in patients with liver cirrhosis compared with healthy individuals (4.8 ± 0.6; 4.2 ± 0.3 nmol/platelet; P > 0.05). Plasma serotonin levels were significantly higher in Child- Pugh grade A/B than in grade C patients (246.8 ± 35.0 vs 132.3 ± 30.7 nmol/L; P < 0.05). However, platelet serotonin content was not significantly different between Child-Pugh grade C and grade A/B (4.6 ± 0.7 vs 5.2 ± 0.8 nmol/platelet; P > 0.05). CONCLUSION: Plasma serotonin levels are significantly higher in patients with cirrhosis than in the controls and represent the degree of liver insufficiency. In addition, platelet poor plasma serotonin estimation is a better marker for liver insufficiency than platelet serotonin content. | ■or■e M ulafi Duko S Mirkovi Miodrag D Vukevi Jelena S Rudi | 2007 | World Journal of Gastroenterology2007，13，43： | 5 |
| 2 | 用传统和超声提取的松果菊(紫锥菊属)的抗氧化和抗菌活性(英文)显示文摘Antioxidant and antimicrobial activities of Echinacea purpurea L. (Asteraceae) extracts obtained by classical and ultrasound solvent extraction were compared. The dry aerial part of plant was extracted by 70% etha-nol at a solid-to-liquid ratio of 1︰10 (m/v) and 25°C. The extract obtained by classical solvent extraction contained 29% larger amounts of phenolic compounds and 20% higher content of flavonoids. 2,2-diphenyl-1-picril hydrazyl radical (DPPH) scavenging reached 93.6% and the values of EC50 were (34.16±0.65) μg·ml-1 and (65.48±1.12) μg·ml-1 for the extracts obtained by the classical and ultrasound extractions, respectively. The extracts, independent of the extraction technique applied, showed a considerable growth inhibition on Candida albicans and Saccharo-myces cerevisiae, while no growth inhibition zones were observed for Aspergillus niger. The diameters of inhibition zone observed for all the microorganisms were larger for extracts obtained by classical extraction than those by ul-trasound extraction. | Ivana Stanisavljevi Sаa Stojievi Dragan Velikovi Vlada Veljkovi Miodrag Lazi | 2009 | Chinese Journal of Chemical Engineering2009，17，3： | 2 |
| 3 | 不同萃取技术获得的Artemisia sp的甲醇提取物其抗氧化和抗菌活性的比较(英文)显示文摘The polyphenol content,antioxidant and antimicrobial activities of the extracts obtained by classical, ultrasonic and Soxhlet extractions from dry aerial parts of two Artemisia species(Artemisia vulgaris and Artemisia campestris)were compared.Ultrasound positively affected the yield of extractive substance and the kinetics of extraction,but the extract obtained by the classical extraction showed the highest antioxidant activities and contained higher total contents of phenolic compounds and flavonoids than the extracts obtained by two other extraction techniques.Both flavonoid aglycones(apigenin,quercetin,quercetin 3,3′-dimethyl ether)and flavonoid glycosides(rutin,hyperoside and kaempferol 3-rhamnoside)were identified by thin layer chromatograph(TLC)analysis in the extracts from both species.A.campestris extracts were richer in quercetin than A.vulgaris and its antimicrobial activity was also better than A.vulgaris.Extracts obtained from both species were found to be more effective on the tested yeasts than bacteria.The kinetics of the total extractive substances,such as phenolic,flavonoids and quercetin extraction,was successfully described by the model of unsteady-state diffusion. | Ivana Karabegovi Milena Nikolova Dragan Velikovi Sаa Stojievi Vlada Veljkovi Miodrag Lazi | 2011 | Chinese Journal of Chemical Engineering2011，19，3： | 1 |
| 4 | Non-linear analysis of plate and folded plate structures by the finite strips method 显示文摘 | Miodrag S Dragan M | 1987 | Engineering Computations1987，4，1： | 1 |
| 5 | Growth hormone-related effects on apoptosis,mitosis,and expression of connexin 43 in bovine in vitro maturation cumulus-oocyte complexes显示文摘 | Sabine K Miodrag S Gudrun B | 2003 | Biology of Reproduction2003，68，： | 1 |
| 6 | Stress Echocardiography in the Detection of Myocardial Is- chemia显示文摘 | Branko D Miodrag O Jelena S | 1994 | Circulation1994，90，： | 1 |
| 7 | Hydrothermal syn-thesis of Li4 Ti5 O12-C nanostructured composites:mor-phology and electrochemical performance显示文摘 | Milica V Vana S Miodrag M | | 0，，： | 1 |
| 8 | Stress echocardiography in the detection of myocardial Ischemia:head-to-head comparison of exercise dobutamine and dipyidamole tests显示文摘 | Branko DB Miodrag O Ielena S | 1994 | Circulation1994，90，： | 1 |
| 9 | On the Newton-likeMethod for the Inclusion of a Polynomial Zero显示文摘 | Ljiljana D Petkovic Miodrag S Petkovi | 2007 | ApplicableAnalysis and Discrete Mathematics2007，1，： | 1 |
| 10 | Growth hormone-related effects on apoptosis, mitosis, and expression of connexin 43 in bovine in vitro maturation cumulus-oocyte complexes显示文摘 | SABINE K MIODRAG S GUDRUN B | 2003 | Biology of Reproduction2003，68，： | 1 |
| 11 | Validation of the chronic liver disease questionnaire in Serbian patients显示文摘AIM:To translate into Serbian and to investigate the validity of the cross-culturally adapted the chronic liver disease questionnaire(CLDQ).METHODS:The questionnaire was validated in 103 consecutive CLD patients treated between October 2009 and October 2010 at the Clinic for Gastroenterology,Clinical Centre of Serbia,Belgrade(Serbia).Exclusion criteria were:age < 18 years,psychiatric disorders,acute complications of CLD(acute liver failure,variceal bleeding,and spontaneous bacterial peritonitis),hepatic encephalopathy(grade > 2)and liver transplantation.Evaluation of the CLDQ was done based on the following parameters:(1)acceptance is shown by the proportion of missing items;(2)internal reliabilities were assessed for multiple item scales by using Cronbach alpha coefficient;and(3)in order to assess whether the allocation of items in the domain corresponds to their distribution in the original questionnaire(construction validity),an exploratory factor analysis was conducted.Discriminatory validity was determined by comparing the corresponding CLDQ score/sub-score in patients with different severity of the diseases.RESULTS:The Serbian version of CLDQ questionnaire completed 98% patients.Proportion of missing items was 0.06%.The total time needed to fill the questionnaire was ranged from 8 to 15 min.Assistance in completing the questionnaire required 4.8% patients,while 2.9% needed help in reading,and 1.9% involved writing assistance.The mean age of the selected patients was 53.8 ± 12.9 years and 54.4% were men.Average CLDQ score was 4.62 ± 1.11.Cronbach's alpha for the whole scale was 0.93.Reliability for all domains was above 0.70,except for the domain 'Activity'(0.49).The exploratory factor analysis model revealed 6 factors with eigenvalue of greater than 1,explaining 69.7% of cumulative variance.The majority of the items(66%)in the Serbian version of the CLDQ presented the highest loading weight in the domain assigned by the CLDQ developers:'Fatigue'(5/5),'Emotional function'(6/8),'Worry'(5/5),'Abdominal symptoms'(0/3),'Activity'(0/3),'Systemic symptoms'(3/5).The scales 'Fatigue' and 'Worry' fully corresponded to the original.The factor analysis also revealed that the factors 'Activity' and 'Abdominal symptoms' could not be replicated,and two new domains 'Sleep' and 'Nutrition' were established.Analysis of the CLDQ score/sub-score distribution according to disease severity demonstrated that patients without cirrhosis had lower total CLDQ score(4.86 ± 1.05)than those with cirrhosis Child's C(4.31 ± 0.97).Statistically significant difference was detected for the domains 'Abdominal symptoms' [F(3)= 5.818,P = 0.001] and 'Fatigue' [F(3)= 3.39,P = 0.021].Post hoc analysis revealed that patients with liver cirrhosis Child's C had significantly lower sub-score 'Abdominal symptoms' than patients without cirrhosis or liver cirrhosis Child's A or B.For domain 'Fatigue',patients with cirrhosis Child's C had significantly lower score,than non-cirrhotic patients.CONCLUSION:The Serbian version of CLDQ is well accepted and represents a valid and reliable instrument in Serbian sample of CLD patients. | Dusan Dj Popovic Nada V Kovacevic Darija B Kisic Tepavcevic Goran Z Trajkovic Tamara M Alempijevic Milan M Spuran Miodrag N Krstic Rada S Jesic Zobair M Younossi Tatjana D Pekmezovic | 2013 | World Journal of Gastroenterology2013，19，30： | 1 |
| 12 | Finite precision effect on performance and complexity of particle filters for bearing - only tracking 显示文摘 | Miodrag B Hong S J Petar M D | 2002 | Department of Electrical and Computer Engineering Stony Brook2002，1，10： | 1 |
| 13 | Analysis of vasore- activity of isolated human radial artery显示文摘 | Natasa S Ljiljana G Miodrag P | 2006 | J Pharmacol Sei2006，100，1： | 1 |
| 14 | Finite Precision Effect on Performance and Complexity of Particle Filters for Bearing-Only Tracking显示文摘 | Miodrag B Hong S J Petar M D | 2002 | Department of Electrical and Computer Engineering Stony Brook2002，1，： | 1 |
| 15 | Developmental regulation of hyaluronan-binding protein expression in early bovine embryos 显示文摘 | Miodrag S Ottheinz K Sabine K | 2003 | Biol Reprod2003，68，： | 1 |
| 16 | Robust computationally efficient control of cooperative close&chain manipulators with uncertain dynamics显示文摘 | Gueaibe W A1-Sharhan S Miodrag B | 2007 | Automatica2007，43，5： | 1 |
| 17 | Analysis of vasoreactivity of isolated human radial artery显示文摘 | NATASA S LJILJANA G MIODRAG P | 2006 | J Pharmacol Sci2006，100，1： | 1 |
| 18 | Comparison of Newer-Generation Drug-Eluting Stents With Bare-Metal Stents in Patients With Acute ST-Segment Elevation Myocardial Infarction显示文摘 | Manel Sabaté Lorenz R?ber Dik Heg Salvatore Brugaletta Henning Kelbaek Angel Cequier Miodrag Ostojic Andrés I?iguez David Tüller Antonio Serra Andreas Baumbach Clemens von Birgelen Rosana Hernandez-Antolin Marco Roffi Vicente Mainar Marco Valgimigli Patri | 2013 | JACC: Cardiovascular Interventions2013，，： | 1 |
| 19 | Coverage Problems in Wireless Ad Hoc Sensor Networks显示文摘 | K Farinaz P Miodrag | 2001 | INFOCOM''012001，，3： | 1 |
| 20 | Spontaneous gastrojejunal fistula is a complication of gastric ulcer显示文摘Spontaneous gastrojejunal fistula formation is an extremely rare complication of gastric ulcer disease. We report a 77-year old woman who presented with diffuse abdominal pain, weight loss, malaise, nausea, and occasional dark stools. Laboratory tests showed extreme hyposideremic anemia with inflammatory syndrome. In addition, biochemical parameters of malnourishmen were presented. Upper endoscopy revealed the paten esophagus along the full length without any pathologica changes. Large and deep ulceration with perforation in the small intestine was detected in the posterior gastric wall. The small intestine loop was reached by endoscope through spontaneously developed gastrojejunal fistula Polytopic biopsies of described ulcerative change were carried out. Histopathologically reepithelialized ulcerous zone was seen in the gastric mucosa. Also gastrojejunal fistula was visualized after wide opening o hepatogastric and gastrocolic ligament. Jejunal loop 25 cm from ligament of Treitz was attached to mesocolon and posterior gastric wall because of ulcer penetration Postoperative course was uneventful. Per oral intake started on the 4th postoperative day, and the patient was discharged on the 8th postoperative day. In summary this case indicates that persistent symptoms of peptic ulcer disease associated with nutritional disturbances may be caused by gastrojejunal fistula. | Dorde M ulafi Olivera D Mateji Vladimir S Duki Miodrag D Vukevi Mirko D Kerkez | 2007 | World Journal of Gastroenterology2007，13，3： | 0 |
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