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		题名	作者	年代	出处	被引量
	1	Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma显示文摘AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis.	Philippe Couvert Alain Carrié Jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly Jean-Claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié	2008	World Journal of Gastroenterology2008，14，35：	6
	2	The H19 locus acts in vivo as a tumor suppressor 显示文摘	Yoshimizu T Miroglio A Ripoche MA	2008	Proc Natl Acad Sci USA2008，105，12：	1
	3	Therapeutic benefits of cardiotrophin-1 gene transfer in a mouse model of spinal muscular atrophy显示文摘	Lesbordes JC Cifuentes-Diaz C Miroglio A	2003	Hum Mol Genet2003，12，：	1
	4	Therapeutic benefits of cardiotrophin-1 gene transfer in a mouse model of spinal muscular atrophy显示文摘	LESBORDES J C CIFUENTES-DIAZ C MIROGLIO A	2003	Hum Mol Genet2003，12，11：	1
	5	The H19 locus acts in vivo as a tumor suppressor显示文摘	YOSHIMIZU T MIROGLIO A RIPOCHE M A	2008	Proc Natl Acad Sci U S A2008，105，12：	1
	6	Therapeutic benefits of cardiotrophin-1 gene transfer in a mouse model of spinal muscular atrophy显示文摘	LESBORDES J C CIFUENTES-DIAZ C MIROGLIO A	2003	Hum Mol Genet2003，12，12：	1
	7	The H19 locus acts in vivo as a tumor suppressor 显示文摘	Yoshimizu T Miroglio A Ripoche MA	2008	Proc Natl Acad Sci U S A2008，105，12：	1
	8	The H19 locus acts in vivo as a tumor suppressor显示文摘	Yoshimizu T Miroglio A Ripoche MA	2008	Proc Natl Acad Sci U S A2008，105，12：	1
	9	The H19 locus acts in vivo as a tumor suppressor 显示文摘	YOSHIMIZU T MIROGLIO A RIPOCHE M A	2008	Proc Natl Acad Sci U S A2008，105，12：	1
	10	Specific hypomethy- lated CpGsat the IGF2 locus act asan epigenetic biomarker for familial adenomatous polyposis colorectal cancer 显示文摘	Miroglio A Jammes H Tost J	2010	Epigenomics2010，2，3：	1
	11	The H19 locus acts in vivo as a tumor suppressor显示文摘	Yoshimizu T Miroglio A Ripoche MA	2008	Proc Natl Acad Sci U S A2008，105，12：	1
	12	The H19 locus acts in vivo as a tumor suppressor显示文摘	YOSHIMIZU T MIROGLIO A RIPOCHE MA		0，，：	1
	13	Therapeutic benefits of car- diotrophin-1 gene transfer in a mouse model of spinal muscular atrophy显示文摘	Lesbordes J C Cifuentes-Diaz C Miroglio A Joshi V Bordet T Kahn A	2003	Hum Mol Genet2003，12，：	1
	14	The 1t19 locus acts in vivo as a tumor suppressor显示文摘	Yoshimizu T Miroglio A Ripoche M	2008	Proc Natl Acad Sci USA2008，105，12：	1
	15	Therapeutic benefits of cardiotrophin-1 gene transfer in a mouse model of spinal muscular atrophy 显示文摘	Lesbordes JC Cifuentes - Diaz C Miroglio A	2003	Hum Mol Genet2003，12，11：	1
	16	The H19 locusacts in vivo as a tumor suppressor显示文摘	Yoshimizu T Miroglio A Ripoche M A	2008	Proc Natl Acad Sci USA2008，105，12：	1
	17	The H19 locus acts in vivo as a tumor suppressor显示文摘	Yoshimizu T Miroglio A Ripoche MA	2008	Proc Natl Acad Sci U S A2008，105，12：	1
	18	Therapeutic benefits of cardiotrophin-1 gene transfer in a mouse model of spinal muscular atrophy 显示文摘	Lesbordes JC Cifuentes-Diaz C Miroglio A	2003	Hum Mol Genet2003，12，11：	1

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